DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LUZP1 and alm1

DIOPT Version :9

Sequence 1:	NP_001136018.1	Gene:	LUZP1 / 7798	HGNCID:	14985	Length:	1076	Species:	Homo sapiens
Sequence 2:	NP_594092.1	Gene:	alm1 / 2542883	PomBaseID:	SPAC1486.04c	Length:	1727	Species:	Schizosaccharomyces pombe

Alignment Length:	1229	Identity:	257/1229 - (20%)
Similarity:	433/1229 - (35%)	Gaps:	397/1229 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAEFTSYKETAS-SRHLRFKLQSLSRRLD--------ELEEATK-NLQKAEDELLDLQDKVIQAE 55
            :|.|:|.||..| :..||.|:::|...::        ::..|.| |.....:::.:|:.::..::
pombe   536 LANFSSIKEAVSKTLELREKVRALECDVEIQKQTVQYQISNAVKENSNTLSEQIKNLESELNSSK 600

Human    56 GSNSSMLAEIEVLRQRVLRIEGK-----------DEEIKRAEDLCRLMKEKLEE--------EEN 101
            ..|.|:|.|..:|::.:......           |:::|..::..|.:::..|.        :|:
pombe   601 IKNESLLNERNLLKEMLATSRSSILSHNSSAGNIDDKMKSIDESTRELEKNYEVYRNEMTAIQES 665

Human   102 LTR---ELKSEIERLQKRMAELEKLE-----------------EAFS------RSKNDCTQLCLS 140
            |::   :|.||:|.::|   |||..:                 |||.      ||.|...|..:|
pombe   666 LSKRNQDLLSEMEAIRK---ELENSKYQQQLSTDRLTNANNDVEAFKKEAKELRSINQNLQDIIS 727

Human   141 LNEERNLTKKISSEL-------EMLRVKVKELESSEDRLDKTEQSLASELEKL---KSLTLSFVS 195
            ..::|  ..|.:.||       |.|:.::...:..:|...:|::.|.||.:||   :...:|.||
pombe   728 RQDQR--ASKFAEELLHVNSLAERLKGELNASKGEKDLRKRTQERLISENDKLLAERERLMSLVS 790

Human   196 E-RKYLNEK-----------EKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS 248
            : :.:||::           |.|.|.|...|.:..|.|:||:.|......:||
pombe   791 DLQTFLNQQQLSDAARKVKFESEKESLSLSLQKLKESNEKMSNDLHSLQKSLE------------ 843

Human   249 TLPSKESRRKGGLDYLKQVENETRNK-SENEKNRNQEDN------KVKDLNQEIEKLKTQIKHFE 306
                     |.|::|..:::.....| |.:|.||...||      |:::||..||..|.:....|
pombe   844 ---------KSGIEYSSRIKTLMLEKQSLSEDNRKLLDNQQMMEIKLQELNGVIELEKQRFSTLE 899

Human   307 S----------------LEEELKKMKSKNNDLQDNY-LSEQNKNKLLA-------------SQLE 341
            :                ||..|..::||:..|:..| .|.:|..:|.|             ::.:
pombe   900 AKFTQQKNTSYSEREALLESSLSDLQSKHTSLESQYNYSLRNIEQLQAASKLAEEMVERVKTEYD 964

Human   342 EIKLQIKKQKE--------LENGEVEGEDAFLSSKGRHER-TKFRGHGSEASVSKHTARELSPQH 397
            |.:||..:..|        ||...|..:|...||..|.|. ||    .||..|:
pombe   965 EYRLQTSESLEKNHLKITSLEQRIVILQDEIASSSLRCENITK----DSETRVA----------- 1014

Human   398 KRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQS 462
                      .|..||..|:|      ..::.|.|:..|:....|...|....|||.
pombe  1015 ----------LLLEENKHLNN------ELSSHRNAEKQHLEKENDYKQQLLLVTEDL-------- 1055

Human   463 EGKKSREQ-PSVLSRYPPA-------AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSV 519
              :|:||. ...|.|:..|       .::::||.:.......|..||..:.:
pombe  1056 --RKTREDYEKELLRHADARSTLQKLREDYTKALEQVEDLNKEIALKAGINE------------- 1105

Human   520 PSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKA 584
             |.|...::|......|....|:    .|...:||            |.||..:.:|..|.....
pombe  1106 -SQPFPISEKEDPLRQEVYVLKK----QNAMLLTQ------------LQSSNLNFAEITSPSPDL 1153

Human   585 ANGLEADNSCPNSKAPVLSKYP--YSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCR 647
            .:.::...|...:....:||..  .||:.|...|:                       ::.|: |
pombe  1154 DSVMKLGLSDLQNHVKRISKEMEIISCQRQLLFLE-----------------------NKKLK-R 1194

Human   648 VIKSSGREKPDSDDDLDIASL---VTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDK 709
            .::||.|.         ||.|   :|.|.|::|.....|.....|.
pombe  1195 TVESSNRV---------IADLQRGITEKDVSSTSESVGERSNYLNM------------------- 1231

Human   710 DAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGT 774
             ..:.|||.||:|.:....|...|           ..||.:.:   :|..:.:..:.|
pombe  1232 -VALLNESNKSLRENLERNEEVIT-----------ELREKIET---LKTDLANFRLNK------- 1274

Human   775 ETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVS 839
             ..||.|....|....|:.:|...|                :||  ...|.:.|...||.|:..|
pombe  1275 -EQLESQLQTEKAAVKKLENSNEEY----------------KRH--NQEILLSLNSSTSTSSDAS 1320

Human   840 SPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIRWKSH 904
            ......:.|.:    |.|......|.||...|||.|:|..:                |..|.::.
pombe  1321 RLKNELVSKEN----LIEELNQEIGHLKSELETVKSKSEDL----------------ENERAQNQ 1365

Human   905 SAPSEVGFSDARHVTVRNAWKSRRDL---KSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELE-Q 965
            |...::   :.::..:..||:::.:.   ||||             ..|...|:.|...|||| :
pombe  1366 SKIEQL---ELKNTKLAAAWRTKYEQVVNKSLE-------------KHNQIRQQLSQKTSELEAK 1414

Human   966 PRSC--LFEQ---------GTRRVGPSSGDAPEPSSRRTQSSLT---VSEVLTRRNRVGDTITVA 1016
            ...|  |.||         .|.:..||:....|.:|.:.:.|.|   :||::...|...:.:...
pombe  1415 VAECHQLNEQLNKPSATPTATTQSEPSTVSLEEFNSTKEELSSTQRKLSEIMDILNTTKEELEKV 1479

Human  1017 AWNHSASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEE 1075
            ..|   |.:.||            .|.| :|:|.::.: |..:|..:|.||.....|:|
pombe  1480 RQN---SNKSEG------------TSKD-TEIPNEEEM-ERKKVMQQEVLRLRSRIAKE 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LUZP1	NP_001136018.1	Lebercilin	104..303	CDD:292252	62/253 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..291		11/51 (22%)
		mycoplas_twoTM	262..>369	CDD:275320	36/151 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..546		40/196 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..600		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..746		11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..819		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..913		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..998		21/83 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1076		11/34 (32%)
alm1	NP_594092.1	Smc	84..885	CDD:224117	82/374 (22%)
alm1	NP_594092.1	SMC_prok_B	764..1567	CDD:274008	209/996 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000