DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment arhgap18 and cv-c

DIOPT Version :9

Sequence 1:	NP_001072336.1	Gene:	arhgap18 / 779789	XenbaseID:	XB-GENE-988160	Length:	662	Species:	Xenopus tropicalis
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	152/720 - (21%)
Similarity:	275/720 - (38%)	Gaps:	197/720 - (27%)

- Green bases have known domain annotations that are detailed below.

Frog    21 KAAAGSNVSNGAEGSPRSRKSGQYTMNQGNVNPSLEKVAFNRSGSQDSLDELSLDDYWTEVENIK 85
            |.....:.|:....|..|...|:.::.:    ||..:....|:|..|.:...|
  Fly  1677 KEGKSDDSSSYYSDSQESSTGGKLSLRK----PSKARRFLQRTGKVDDIGAHS------------ 1725

Frog    86 QDTNTSQDEQNVVKEPDEG--ELEEEWLKEAGLSNLFNECAADPQESIVLLSTLTKTQSAAVQKR 148
             |:...|..:.::|:.:..  |::.:.|...|..||    ..||::.....|:..:::|
  Fly  1726 -DSECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNL----GKDPKKRDGFRSSSFRSRS------ 1779

Frog   149 IDTVTQTLRKKNRQHQIPDVRDVFKQPVNLQDKAGDINGFQSTESNDPKNEEANEKAECVAPEAS 213
                  |.||:.:               |.:|.||      :|.:...|.:
  Fly  1780 ------TSRKEAK---------------NDEDTAG------ATTNGGSKRQ-------------- 1803

Frog   214 RNVGDDLPVPVTDINLEISF-AEQASNL---KDFTRVRNEKEDDSLLPNFRLTQDKTGTTKIGDL 274
                     ||...:   || .|:..|:   |.|::.....::|:            |......:
  Fly  1804 ---------PVVRWH---SFQMEERPNMIFRKCFSKKIEPLQEDA------------GGMPFAAM 1844

Frog   275 APQDMKKVSSLALIELTALYDVLGTELKMQR----------------AAKIKV---RESGLFRVP 320
            :...::.:..|||:.||.         .|:|                ..|||:   ::..:|.||
  Fly  1845 SAGQLQIIRKLALVTLTG---------HMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVP 1900

Frog   321 LSTLLDQDQKRAPGTRVPLIFQSLIGHIEKGGLDTEGILRIPGASARIKALIEELEAKFYEGTFN 385
            |..:|.:.     |..:||..::....::...||..||.|..|..:||..|.|::|..  :.|..
  Fly  1901 LLMILQRS-----GQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVT--DSTAE 1958

Frog   386 ----WDNVKQHDAASLLKFFIRELPLPLLTVEYLKAFHSV-QYLPTKKHRLQALNLLVILLPEIH 445
                :|..:.:|.|.:||.:.||||..|||.:..:.|.:: |:||.:. ||.|:...|:|||:.:
  Fly  1959 CMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEV-RLDAVQCAVLLLPDEN 2022

Frog   446 RDTLKALLEFLQRVVDHREQNKMILKNVAMIMAPNLF--SVHTYQLKTVDQGALEGAFS------ 502
            |:.|..|||||..|..:.:||:|...|:.:.:|.::|  |:.|...........:|..|
  Fly  2023 REILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPRRKGKGSGMPDMK 2087

Frog   503 ----AARTASVMLFMIKYQNLLWTIPKFIVAQVRRQNIVNQKKLSKEKPMKKLLKRMAYD--REK 561
                |..:...:.|||::...::|..|   .::.:.|....:: ||..|::.|.:.|.:.  |..
  Fly  2088 ELAEAKASHECLSFMIEHYKQIYTAAK---EKLSKCNFSYMEE-SKPLPLEALGEGMQFHNWRGY 2148

Frog   562 SEKCTSE-----NDAPQGFIRVQAPQFSKVSMAV------------QLTAELKA--GEILARFLS 607
            ..:|||.     .:..:|:..:.:...|.|.:|.            :.:.|::.  .|:|...:.
  Fly  2149 LYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIK 2213

Frog   608 QESS-----VTERNIKK----EEVCLYEIGGNIVGRCLEDSTYMKDLFQLNPNAEWVI------- 656
            |.:|     :..:.:||    .|:..|.:.|.:........::..||    |....||
  Fly  2214 QRASWDTNLLQCQTVKKLDDRTEIYQYALDGQLTTDFCVLRSWQTDL----PRGACVIVETSIDH 2274

Frog   657 -KAKP 660
             ||||
  Fly  2275 AKAKP 2279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
arhgap18	NP_001072336.1	RhoGAP_ARHGAP18	316..532	CDD:239856	67/232 (29%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	67/233 (29%)
		SRPBCC	2148..2343	CDD:301327	26/136 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910