DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nuak1 and par-1

DIOPT Version :9

Sequence 1:	NP_001004363.1	Gene:	Nuak1 / 77976	MGIID:	1925226	Length:	658	Species:	Mus musculus
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	212/767 - (27%)
Similarity:	328/767 - (42%)	Gaps:	176/767 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 EGAAVSAAGDGPAVETGL-------PGSPLEAVAGATAAPVEPRKPHGVKRH----HHKHNLKHR 55
            :||.:|:........:.:       |||.:...............|..:|:.    ....|::.|
  Fly   172 DGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMR 236

Mouse    56 ----------------YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRRE 104
                            |:|.:|:|||.:.|||.|....:|:.||||.|.|.::... .:..:.||
  Fly   237 SSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPG-SLQKLFRE 300

Mouse   105 IEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHY 169
            :.||..|:||:|:.:::|.|.:..:.:||||||.||::||:....|:.|:|.|..||||||||.|
  Fly   301 VRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQY 365

Mouse   170 CHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPE 234
            ||:..::|||||.||:|||...||||||||.||.:.....|.||||||.||:||:..|:.|.|||
  Fly   366 CHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPE 430

Mouse   235 VDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATI 298
            ||.|:|||:||||:.|::||||...:.|..::..|:||.|...| |...|:|..|::||.:||::
  Fly   431 VDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASL 495

Mouse   299 EDIANHWWVNWGY-----------KSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKG 352
            |.|....|:|.|:           |:.:.|    |.....|:|.   .::||     |.||.:..
  Fly   496 ETIMGDKWMNMGFEEDELKPYIEPKADLAD----PKRIEALVAM---GYNRS-----EIEASLSQ 548

Mouse   353 LAKPG--ASEVVLERQRSLKKSKKENDFPQSGQD------------------------------S 385
            :....  |:.::|.|    |.:..|:|..:||..                              |
  Fly   549 VRYDDVFATYLLLGR----KSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRS 609

Mouse   386 VPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSP--------------ALPSPFKMEQDL 436
            :..|.:|.|.:...|:....:.:...: :||.: |.|:|              ::.|.||.:..:
  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAA-ATGAV-GAVNPSNNYNAAGSAADRASVGSNFKRQNTI 672

Mouse   437 CRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISG 501
                                  .|||      :|:...|.:.....| .|.:.::|.:.|..
  Fly   673 ----------------------DSAT------IKENTARLAAQNQRP-ASATQKMLTTADTT--- 705

Mouse   502 GLSSPPP-------DPAR------GTSHSLSCRRKGILKHSSRYSDGGTDPALT----RPEMPTL 549
             |:||..       ||..      |||..:..|...:.:.:|........||.|    |..|.:.
  Fly   706 -LNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASA 769

Mouse   550 ESLS---PPGVPS-----DGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAE 606
            ...|   |..|||     .|.:|:.:..:...|..|..|.||        :.|.|....|.:|:
  Fly   770 VKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDS--------SHPGRMSFFSKLSS- 825

Mouse   607 NFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN 658
            .|.:.........:||.........::..|:.|     |:.:|..|:..:.|
  Fly   826 RFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPD-----QIMQKIREVLDQNN 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nuak1	NP_001004363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		9/61 (15%)
		STKc_NUAK	54..307	CDD:270975	120/269 (45%)
		S_TKc	56..307	CDD:214567	119/251 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..422		16/100 (16%)
		GILK motif	400..403		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..568		31/151 (21%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/252 (47%)
		S_TKc	253..504	CDD:214567	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/49 (22%)
		MARK1-3_C	839..936	CDD:213381	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910