DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf145 and HRD1

DIOPT Version :9

Sequence 1:	NP_001072260.1	Gene:	rnf145 / 779713	XenbaseID:	XB-GENE-979193	Length:	695	Species:	Xenopus tropicalis
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	109/533 - (20%)
Similarity:	189/533 - (35%)	Gaps:	142/533 - (26%)

- Green bases have known domain annotations that are detailed below.

Frog   182 EVLYFLASNLLVPFNLAKSAYRELAQVVEV-------YGLLALGM-------SLWNQLVVPVLFM 232
            ::..|:....|:.|....||.:.....::|       :.|:.|.:       .|| ||:..:||.
Yeast     9 QLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLW-QLLTKLLFG 72

Frog   233 VFWLV----LFALQIYTYFSTRDQPTSRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLT 293
            ...|:    :|....:|..:|            ||::|:..   ..|     .|||:|  .|:|.
Yeast    73 ELRLIEHEHIFERLPFTIINT------------LFMSSLFH---ERY-----FFTVAF--FGLLL 115

Frog   294 LCKFYLQGYRAFMND--PAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQS 356
            |   ||:.:...:.|  .|:.:.:.:..|:..|........|      .||:::.:.::...:.|
Yeast   116 L---YLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNL------VLLAVVDYQIITRCISS 171

Frog   357 MLEIADPIVLALGASRDKSLWKHFRAVSLCLF-LLVFPSYMAYMICQFFH--MDFWLLIIISSSI 418
            :.            :..||   ...:.||.|. ::.|...:..::..|..  ::||       ..
Yeast   172 IY------------TNQKS---DIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFW-------EF 214

Frog   419 LTSLQVLGTLFIYVLF-------MIEEFRKEPVENMDDVIYYVNGTYRLLE--FLVALCVVAYGV 474
            ..|.|.|.....:::.       .:|..:.:||.|.||.....:..:..||  |:....:..:
Yeast   215 YRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVF-- 277

Frog   475 SETVFGEWTVMGSMIIFIHS--------YYNVWLRAQLGWKSFLLRRDAVNKIKSLPVATKEQLE 531
              |.|.:..:..||:|....        .:::....|.|...:.:.|:......:|...|.|||:
Yeast   278 --TRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQ 340

Frog   532 QH-ND--ICSICYQDM-------------NSAVITPCSHFFHPGCLKKWLYVQETCPLCHCQL-- 578
            .. ||  ||.||..::             ......||.|..|..|||.|:...:|||:|...:
Yeast   341 NSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFD 405

Frog   579 -KSLSQQATGESGS----------STNPVSEQS------------ATNPPLGPVSRAEVTTEPLA 620
             |....|.|..|.|          ||...::|.            .|:|.:..|....:.|   .
Yeast   406 EKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDT---L 467

Frog   621 AVPTRSALEQEPT 633
            |:.|||.....||
Yeast   468 AMRTRSTSTPSPT 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145	NP_001072260.1	TRC8_N	8..506	CDD:372682	66/363 (18%)
		RING-H2_RNF145	533..575	CDD:319598	17/57 (30%)
		rad18	537..>651	CDD:273165	33/135 (24%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610		8/46 (17%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	109/533 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910