DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf145 and IRC20

DIOPT Version :9

Sequence 1:	NP_001072260.1	Gene:	rnf145 / 779713	XenbaseID:	XB-GENE-979193	Length:	695	Species:	Xenopus tropicalis
Sequence 2:	NP_013348.1	Gene:	IRC20 / 850949	SGDID:	S000004237	Length:	1556	Species:	Saccharomyces cerevisiae

Alignment Length:	368	Identity:	75/368 - (20%)
Similarity:	123/368 - (33%)	Gaps:	106/368 - (28%)

- Green bases have known domain annotations that are detailed below.

Frog   413 IIS---SSILTSLQVL-GTLFIYVLFMIEEFR-----------KEPVENMDDVI--YYVNG---- 456
            |||   ..:|.||::: ||....|...::..|           :..::|.:|.:  |.|..
Yeast  1083 IISKYQKQLLNSLRLISGTPLRTVFDELKNSRIVRRISSSNESESTIQNFEDYLLQYEVESKSLF 1147

Frog   457 --TYRLLEFLVALCVVAYGVSETVFGEWTVMGSMIIFIHSYYNVWLRA-QLGWKSFLLRR----- 513
              ..::.|.|..|..: |......:.:...:...::.:||     |.| ||   |.|:|.
Yeast  1148 KYNKQVRESLKILGSI-YNAKTEYYSQLQRISDSLVSLHS-----LSAPQL---SHLIRTINKSL 1203

Frog   514 ----DA-VNKIKSLPV------ATKEQLEQHNDI-CSICYQDMNSAVITPCSHFFHPGCLKKWLY 566
                || :|.|:|..:      ..|:.|..:..: ||||..::....|..|.|:|...|:..||.
Yeast  1204 GGTLDAKINNIESRLIYLKNLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLR 1268

Frog   567 VQETCPLC--HCQLKSL-----------------SQQATGESGSSTNP-----VSEQSATNPPLG 607
            ....||:|  .|.:..:                 ..:..|...|..|.     :|..|......|
Yeast  1269 AHSKCPICKGFCSISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEKLFG 1333

Frog   608 P------------------------------VSRAEVTTEPLAAVPTRSALEQEPTMDIKVSGSV 642
            .                              :|...:.:|...|.|.:..|..:.|..:||.|.|
Yeast  1334 NKYEQFHQINEVHQIHIKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLKVIGKV 1398

Frog   643 EKRIGELEAHFSQGEANLNSNEVLQRLQAKGEANPEDLNVKAL 685
            .| :..:| |.:......|..|.:...:.:.......||||.|
Yeast  1399 LK-LYHIE-HLACLSNTANVGETINNFKRQPSVTCLLLNVKTL 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145	NP_001072260.1	TRC8_N	8..506	CDD:372682	24/116 (21%)
		RING-H2_RNF145	533..575	CDD:319598	14/44 (32%)
		rad18	537..>651	CDD:273165	32/167 (19%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	13/36 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610		6/59 (10%)
IRC20	NP_013348.1	HepA	172..>568	CDD:223627
		DEXQc_SHPRH	383..602	CDD:350828
		RAD18	1234..>1327	CDD:227719	19/92 (21%)
		RING-HC_RNF10	1239..1276	CDD:319450	13/36 (36%)
		SF2_C_SNF	1356..1485	CDD:350180	20/86 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910