DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf145 and rnf-145

DIOPT Version :9

Sequence 1:	NP_001072260.1	Gene:	rnf145 / 779713	XenbaseID:	XB-GENE-979193	Length:	695	Species:	Xenopus tropicalis
Sequence 2:	NP_491382.2	Gene:	rnf-145 / 172053	WormBaseID:	WBGene00022471	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	649	Identity:	183/649 - (28%)
Similarity:	331/649 - (51%)	Gaps:	56/649 - (8%)

- Green bases have known domain annotations that are detailed below.

Frog     4 KEKLEAMLNVALRVPSIMLLDVLYRWDVSSFFKQIQRSSLNNNPLFQY---------------KY 53
            ||....:|...||:|.::.:::|:|:...| |:.|....:...||..:               .:
Worm    45 KEMSIMVLETGLRLPGLLFIELLWRYQGFS-FEDISDDMMKQTPLSYFDIPTMLDFVHRRNFDHH 108

Frog    54 LALNMHYVGYILSVVLLTLPRQHLAKLYLYFVAALLLYAGHQISRDYVRSELESGYEGPMHIEPL 118
            .|:.:.|....:|::.||||...|.::|.:|::..|....:::|..||..|:::| |..:.::.|
Worm   109 AAIILSYFVIFISLMFLTLPLSRLIRMYSHFLSVFLFGVAYKLSAIYVDLEMKTG-EEELKLDGL 172

Frog   119 -SMNRFITALVGQLVVCTLCSCVMKTK-QIW--LFSAHMLPLLARLCLVPIETIVVINKFA---- 175
             .:.|.....:.|:::..|.|.:::.. :.|  ......||::||:|..|::.:...:.:|
Worm   173 IKLERHGFHFLAQMLLVVLQSMLLEVDGEPWRVALPVFALPIVARMCGCPMDKLKNAHNYACTGT 237

Frog   176 MIFTGLEVLYFLASNLLVPFNLAKSAYRELAQVVEVYGLLALGMS-LWNQLVVPVLFMVFWLVLF 239
            |||....:|| .|.:|:   ...|:|.|::..|..|:| ||.|:: ||.:|.:..|....|:.:|
Worm   238 MIFIATYMLY-RAPSLI---KSTKTALRQIKAVFMVHG-LADGVAVLWRKLRILELLTFTWITMF 297

Frog   240 ALQIYTYFSTRDQPTSR-ERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYR 303
            .:.:|.....:.:..|. .|:|   ||.:||..:||.:|..|..:||:|...:..|.|....|.|
Worm   298 LMVLYVELIDKGRTWSEVGRIL---LTGVAETTNTPITLAALAVSVSYVCKWIADLTKLITGGTR 359

Frog   304 AFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLAL 368
            :..:..| :.|.||.|:::||.:|||.:.:||..:..||:::|:||::::|||:.||.:.::|.|
Worm   360 SHGHVLA-HSGYTEAVSVVILCIQTGFLGMQVEQKTILLALVLYIVISALLQSLFEIIEVVLLNL 423

Frog   369 GASRDKSLWKHFRAVSLCLFLLVFPSYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVL 433
            .:|...|..:|.|.:.:.|.|:|.|.:....:.....:|.:..|||::|...:.:.:|.:..|::
Worm   424 PSSPTASRARHARCICIALLLVVIPFFTTKTMLALLPIDIYTAIIIANSATVTARAIGVILKYIV 488

Frog   434 FMIEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETVFGEWTVMGSMIIFIHSYYNV 498
            .::|...:||.|.:||:.||::...:.:|.|.|..|:.:|..:.|...::.....|:..|...|:
Worm   489 LIVETKSEEPWEGIDDLTYYIDCANKGIELLAAKVVMVFGCMQVVKVGFSFATFAILLFHVIVNI 553

Frog   499 WLRAQLGWKSFLLRRD-AVNKIKSLPVATKEQLEQHNDICSICYQDM-NSAVITPCSHFFHPGCL 561
            :.|.: ...||:..|: ||..|..|..|...||.:..|:|:||:.:| ..|.||||.|:||..||
Worm   554 YKRLE-HTVSFIKNRNAAVKNINRLSKADVVQLREREDVCAICFIEMKEEARITPCKHYFHGPCL 617

Frog   562 KKWLYVQETCPLCHCQLK------------SLSQQATGESGSST-----NPVSEQSATNPPLGP 608
            :|||.|:..||||:..:|            :|::....|.|::.     ||..:..|.|....|
Worm   618 RKWLAVKMVCPLCYTYMKEDDFDSKSSSSGTLNEVQQNEEGAAVEENPENPEEQPEAPNAERAP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145	NP_001072260.1	TRC8_N	8..506	CDD:372682	139/522 (27%)
		RING-H2_RNF145	533..575	CDD:319598	22/42 (52%)
		rad18	537..>651	CDD:273165	31/90 (34%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	20/37 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610		7/29 (24%)
rnf-145	NP_491382.2	TRC8_N	49..556	CDD:372682	138/517 (27%)
rnf-145	NP_491382.2	RING-H2_RNF139_like	590..631	CDD:319390	22/40 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I2007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I2128
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		otm21068
Panther	1	1.100	-	-	O	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7680
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.110