DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf145 and RNF145

DIOPT Version :9

Sequence 1:	NP_001072260.1	Gene:	rnf145 / 779713	XenbaseID:	XB-GENE-979193	Length:	695	Species:	Xenopus tropicalis
Sequence 2:	NP_001186309.1	Gene:	RNF145 / 153830	HGNCID:	20853	Length:	693	Species:	Homo sapiens

Alignment Length:	703	Identity:	571/703 - (81%)
Similarity:	598/703 - (85%)	Gaps:	70/703 - (9%)

- Green bases have known domain annotations that are detailed below.

Frog     1 MGAKEKLEAMLNVALRVPSIMLLDVLYRWDVSSFFKQIQRSSLNNNPLFQYKYLALNMHYVGYIL 65
            |.|||||||:|||||||||||||||||||||||||:|||||||:|||||||||||||||||||||
Human    31 MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYIL 95

Frog    66 SVVLLTLPRQHLAKLYLYFVAALLLYAGHQISRDYVRSELESGYEGPMHIEPLSMNRFITALVGQ 130
            ||||||||||||.:|||||:.||||||||||||||||||||..|||||::||||||||.|||:||
Human    96 SVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQ 160

Frog   131 LVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPIETIVVINKFAMIFTGLEVLYFLASNLLVPF 195
            ||||||||||||||||||||||||||||||||||:||||:|||||||||||||||||.||||||:
Human   161 LVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPY 225

Frog   196 NLAKSAYRELAQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYTYFSTRDQPTSRERLL 260
            ||||||||||.||||||||||||||||||||||||||||||||||||||:||||||||.||||||
Human   226 NLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLL 290

Frog   261 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILA 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   291 FLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILA 355

Frog   326 VQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   356 VQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLL 420

Frog   391 VFPSYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMIEEFRKEPVENMDDVIYYVN 455
            |||:|||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Human   421 VFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVN 485

Frog   456 GTYRLLEFLVALCVVAYGVSETVFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIK 520
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Human   486 GTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIK 550

Frog   521 SLPVATKEQLEQHNDICSICYQDMNSAVITPCSHFFHPGCLKKWLYVQETCPLCHCQLKSLSQQA 585
            |||:|||||||:|||||:||||||.||||||||||||.||||||||||||||||||.||:.||.
Human   551 SLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQL- 614

Frog   586 TGESGSSTNPVSE-----------QSATNPPLGPVSRAEVTTEPLAAVPTRSALEQEPTMDIKVS 639
               .|..|.||.:           |..|.||                       .||.|...::.
Human   615 ---PGLGTEPVLQPHAGAEQNVMFQEGTEPP-----------------------GQEHTPGTRIQ 653

Frog   640 GSVEKRIGELEAHFSQGEANLNSNEVLQRL---------------QAKGEANP 677
                             |.:.::||.:.|.               .||.||:|
Human   654 -----------------EGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHP 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145	NP_001072260.1	TRC8_N	8..506	CDD:372682	474/497 (95%)
		RING-H2_RNF145	533..575	CDD:319598	38/41 (93%)
		rad18	537..>651	CDD:273165	52/124 (42%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	33/36 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..610		8/35 (23%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	474/497 (95%)
		zf-rbx1	<564..605	CDD:289448	37/40 (93%)
		zf-RING_2	565..605	CDD:290367	36/39 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	951	1.000	Domainoid score	I759
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14427
Inparanoid	1	1.050	1115	1.000	Inparanoid score	I2566
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D119734at7742
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		oto158775
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7680
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110