Protein Alignment gpr158 and CG43795

DIOPT Version :10

• Sequence 1: XP_002933190.2
• Gene: gpr158 / 779597
• XenbaseID: XB-GENE-950420
• Length: 1291
• Species: Xenopus tropicalis
• Sequence 2: NP_001097435.2
• Gene: CG43795 / 5740629
• FlyBaseID: FBgn0264339
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1182
• Identity: 259/1182 - (21%)
• Similarity: 455/1182 - (38%)
• Gaps: 328/1182 - (27%)

 Frog   125 NFLNMMLQSNKSREHNWERDVEWYYALIKSILEGEPAIFRSAVAFN-----VEPSSHVPQVFLRA 184
            |..||:.:..|:...:.:.||...:|.:.|::|.:..||.:...|:     .:|....|..:...
  Fly   452 NRANMLTRIFKTTGRSVQEDVNLLHASVLSMVEFDDDIFAAGNCFDWNEHPAQPGLFCPFAYRLP 516

 Frog   185 TREEGKIHLQDLSASAHGPGNATWEHDW---------------------LHTFKHRSRPHLHKRL 228
            ....|.:..:||:...|..||.:   :|                     .|.:.:|:...:....
  Fly   517 PPNLGAVFAKDLAMEYHYLGNTS---EWFFLARKNAEKVIARNEQYLKSFHLYSNRTEERIEDDT 578

 Frog   229 LHGAKTFDDGWKKGNSYVTDRSHVKWSSPYLECENGKYRPHWLLSLSAAFYGLKPNLVREFRGVL 293
            |  |..::||              :||.||.:|..|..   |:|:.:..|:|.: |....|:|..
  Fly   579 L--AVKYEDG--------------RWSKPYYDCGGGNI---WMLTYTVPFFGYE-NGTYHFKGTS 623

 Frog   294 KVDVNLQNIDIDQCSNE---------GWFSGTHRCQHNSSKCIPTKGLGFVLGAYKCTCKAGFYY 349
            .:|::|:.:|||||...         ..|:||.:|:..::.|....||||..|:|||.|:.|||:
  Fly   624 GIDIDLRRVDIDQCPQRHTPGTKRPLNIFAGTDKCKQRTTMCEAIMGLGFRRGSYKCLCRKGFYF 688

 Frog   350 P---------HGMFSENGFQRPNMVNHFPRGEISEEEYKCLPCREGCSNCTDDAPCYAQEDKYLR 405
            |         :|...|..:::..:..:....  |..||:||||.|||.:|.|.:||.|..:..:|
  Fly   689 PDIVSQHKFFNGSLLEEEYEKLMLGKNSTYN--SNSEYECLPCAEGCDSCEDSSPCIAALNWPMR 751

 Frog   406 IAIISFQAFCMLLDFISMLVVYSFR--RAKSVRASGLVLLEVILFGSLLLYFPVVILYFEPSTFR 468
            .:|::..  |:::..:.....::||  :.|.|||:...||.||..|:..:|...:::|..|:.:.
  Fly   752 TSILALA--CIVIGLLPPAAWFTFRYQQVKVVRAASPALLRVIALGAFFIYCTNIVMYPNPNLYT 814

 Frog   469 CILLRWVRLLGYATVYGTVTLKLYRVLKVFLSRTAQRIPYMTSGRVIRMLSVILLLVLWFLVAWT 533
            |....|:|.:|::..||.:.||.:|:..:|..|:|:.:. :|...:::.|.:|...:...|:..|
  Fly   815 CTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAVK-ITDAALLKRLGIICGAIGTCLLVRT 878

 Frog   534 SAVCQNMDRNIPLIVQGETSDNLQFKMCLIDRWDYMMAVAEFLFLLWGVYLCYAVRTVPSAFHEP 598
            ..       :.|.:|.|.|:|:|:..:|..|.|||.....|.|||.|||.||..||..||.|:|.
  Fly   879 LV-------SPPDVVVGRTADDLKAFLCKTDWWDYTFTSMEVLFLAWGVRLCIMVRKAPSEFNES 936

 Frog   599 RYMAFAVHNELIFSALFHTIRFVLASKLQPDWMLMLFFVHTHLTVTVTVGLL------LIPKFSR 657
            |:::.|::||.:.:...:.....|.|...||.:.::||.||.||||:.:.|:      ::.:..:
  Fly   937 RFISMAIYNEFLLTCFLNVSMLFLQSPANPDLLYIIFFCHTQLTVTLLLALIFGSKVYIVLRSGK 1001

 Frog   658 SHNNPRDDIAAEAYEDELDLG--RSGSYLN-----------SSITSAW----SEHSLDPEDIREE 705
            ||            ::.:.:|  .||:..|           ||:|::.    :|..|..::..||
  Fly  1002 SH------------QENIGMGTKASGAKFNFRPQVRTFANPSSVTTSTVPVAAETKLSDQEALEE 1054

 Frog   706 LKKLYTQLEIYKRKKMIANNPHLQKKRCSKKGLGRSIMRRITEIPD------------------- 751
            :::|..||:            .:|:....|   |.::| .|:.:.|
  Fly  1055 IRQLSMQLQ------------RIQEMAPPK---GVAVM-TISSLLDGLKTPGGLMVVAAAAGATA 1103

 Frog   752 ----SVSRQCS--------KEEKDTTDHGNPKNNVGSSKKHPQESVTHNAKSKEEPSKHKLYSMK 804
                :.:||.:        :.:|.:..:.|.....||.:......|.....|...||........
  Fly  1104 QGHSAANRQSALPLLALNVEMQKYSQQNNNSNGGRGSGRTSIPTMVLETPPSSTPPSAAYEERAV 1168

 Frog   805 KSHSSYDHLRSE--SDTPNG--ISTEKVDVCKNSIY-SPVNGK-----KPNKNGSELEAVSADNV 859
            .:..|.|..|.:  ..|.:|  |.:..:|..|...| .|....     .|.:.||    :|..|:
  Fly  1169 NTELSGDDFREQLLRRTADGHIICSRCLDASKEHYYCCPPRSACDHLGSPKEEGS----LSFANI 1229

 Frog   860 PLVCKSASAHNLSVDKKPLHPSLSVLQKSLSAVANSKDNSLGLRDKTQSVEDTDKCHRTDSAYHE 924
            .|.|..:.:.:|                         |..:|.|                    :
  Fly  1230 KLECMCSQSEDL-------------------------DQDVGQR--------------------Q 1249

 Frog   925 HQPSVATFDKEERQQHTSSPIEEIQKLHKSGIMKQQAMSPHLPESEKFITAMGYKDKFDIEEVCP 989
            .:|:|       |...|::|....::..:           :|.|:|..|:       :.|.:.|
  Fly  1250 RRPTV-------RTAATNTPPTSCKRAPR-----------NLLEAELSIS-------YQICDNC- 1288

 Frog   990 WEMYDLPPSVPSENKVQKHVSIAPLESEKNHTSRSKSKSHNRSKSGEHGH-QQSKQKGHTKTEPN 1053
                                             |||.|...|.:||.:.. |::.|.|
  Fly  1289 ---------------------------------RSKYKLTGRRRSGSYSQAQENPQLG------- 1313

 Frog  1054 IRGTQEQLSKEEQFKQLPTNDANT--MDQQAATKQTTKSHEKEGKKNIALVEGVLTSPEPHHNSN 1116
                      ::...|||....:|  :|:..|.:..|:. |...|...:..:.||.|..|...:
  Fly  1314 ----------QQPAGQLPIQSRSTELLDRTTAAEVETEV-EARTKAAHSTDDIVLYSSAPEELA- 1366

 Frog  1117 NNLPQPLVLRAEVCPWDFENPDVLSVEKSKTSPTTTVLSPTSPSRNMATSPLKKKVLGMPIKVTS 1181
            ..|.:|:..           |.:.:|..:..:.|:.....|.|.|              |.|:..
  Fly  1367 AQLAEPVAA-----------PSLGNVSSNSNNSTSGSGGTTRPKR--------------PDKLVL 1406

 Frog  1182 ANKDAGTKTKDL 1193
            ...|....||::
  Fly  1407 DLNDRSKYTKEV 1418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gpr158	XP_002933190.2	7tmC_GPR158-like	403..660	CDD:320420	78/264 (30%)
		TM helix 1	403..428	CDD:320420	3/24 (13%)
		TM helix 2	440..461	CDD:320420	6/20 (30%)
		TM helix 3	470..494	CDD:320420	7/23 (30%)
		TM helix 4	514..534	CDD:320420	3/19 (16%)
		TM helix 5	563..589	CDD:320420	13/25 (52%)
		TM helix 6	597..620	CDD:320420	5/22 (23%)
		TM helix 7	629..654	CDD:320420	10/30 (33%)
CG43795	NP_001097435.2	PDC1_MCP_like	448..629	CDD:350338	41/199 (21%)
		7tmC_GPR158-like	749..998	CDD:320420	77/258 (30%)
		TM helix 1	749..774	CDD:320420	3/26 (12%)
		TM helix 2	786..807	CDD:320420	6/20 (30%)
		TM helix 3	816..840	CDD:320420	7/23 (30%)
		TM helix 4	859..879	CDD:320420	3/19 (16%)
		TM helix 5	901..927	CDD:320420	13/25 (52%)
		TM helix 6	935..958	CDD:320420	5/22 (23%)
		TM helix 7	967..992	CDD:320420	10/24 (42%)