Protein Alignment ZYX and jub

DIOPT Version :10

• Sequence 1: NP_003452.1
• Gene: ZYX / 7791
• HGNCID: 13200
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_572930.3
• Gene: jub / 32351
• FlyBaseID: FBgn0030530
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 656
• Identity: 178/656 - (27%)
• Similarity: 272/656 - (41%)
• Gaps: 144/656 - (21%)

Human     2 AAPRPSPAISVSVSAPA-FYAPQKK-FGPVVAPKPKVNP-------FRPGDSE----PPPAPGAQ 53
            |.|||...|..:.:..| .|||..: .|..:||: |.:|       :...||.    .|.:||::
  Fly   106 ATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAPQ-KHSPVYENLEFYGQFDSNHKRAQPQSPGSR 169

Human    54 RA------------QMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPP-------- 98
            ::            :.||....|.|            ...|..:.|....|..||||
  Fly   170 QSAILNGYLLMQPIRAGRFAHTPVP------------ENQGSASLGTTRAAGGPPPPSGRSAALG 222

Human    99 ---PIEESFPPAPLEEEIFPSPPPPPEEEGGPEA-----PIPPPPQPREKVSSIDLEIDSLSSLL 155
               .:||.  .||:.|.|.|......:.:..|..     .:.|........|:..|::::|
  Fly   223 PTGDLEEH--AAPIYENIIPHSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLDLNAL---- 281

Human   156 DDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGT---APLPPWKS---PSSSQPLPQVPA 214
                                 :|:|...:|.:...|..:   :|...:::   ||...|:|...:
  Fly   282 ---------------------LASPMHQRSISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQS 325

Human   215 PAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQ-----------------PRGPPASSPAP 262
            .|:.|     |..|...|...::|......:...|:.                 ..|..|::.||
  Fly   326 VAKLQ-----QHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAP 385

Human   263 APK------------------FSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSP 309
            |.:                  .:|.|....|.::..:|.||..:.|.....:.....|:..| ||
  Fly   386 AQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLAVAT-SP 449

Human   310 QP-PSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHP 373
            .| ...|......|||....::.:|      ..|..|...||...:  .::|:||:||.:::|..
  Fly   450 TPSQGSTAVNAALKPRRGLTKNLLP------YSVTPPRPAGPTEAQ--RKIEELTRQLEEEIEQS 506

Human   374 QRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCY- 437
            :....... :|..|.:.:..|..|.:|:|.|:|..||.|..|.:.|:|:.||::.|..|||..|
  Fly   507 EEHGEYFG-ICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYM 570

Human   438 ----TDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHK 498
                ..|.|||..||..|.:.:|:|.||:|||.||.|.||...|:|..|.||..::.:||.|||:
  Fly   571 YSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHR 635

Human   499 QYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCR 563
            .:||:|:.|.:.|.|..|.|||||||::||:||:.||.||:||..|:.|.|.. |:||||.:|||
  Fly   636 MFAPKCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKR-CYPLDGRLLCR 699

Human   564 KCHTAR 569
            .||..|
  Fly   700 GCHLQR 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZYX	NP_003452.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..351		74/409 (18%)
		PAT1	<201..>365	CDD:401645	40/202 (20%)
		LIM1_Zyxin	351..437	CDD:188735	26/85 (31%)
		LIM	444..503	CDD:413332	27/58 (47%)
		LIM3_Zyxin	504..570	CDD:188819	36/66 (55%)
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	20/52 (38%)
		LIM2_Ajuba_like	581..633	CDD:188741	23/51 (45%)
		LIM3_Ajuba_like	641..702	CDD:188822	33/61 (54%)