Protein Alignment ZYX and Zyx

DIOPT Version :10

• Sequence 1: NP_003452.1
• Gene: ZYX / 7791
• HGNCID: 13200
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_652015.1
• Gene: Zyx / 317824
• FlyBaseID: FBgn0011642
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 185/585 - (31%)
• Similarity: 254/585 - (43%)
• Gaps: 116/585 - (19%)

Human    53 QRAQMGRVGEIPPPPPEDF-----------------PLPPPPLAGDGDDAEG------ALGGAFP 94
            |.|.:.|..:|||.||..:                 ||...||.|......|      .|...|.
  Fly    41 QNASVKRRLDIPPKPPIKYNEMPQVPSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFG 105

Human    95 PPPPPIEESFP---PAPLEE--EIFPSPPPPPEEEG------GPEAPIPPPPQPREK-------- 140
            .....|.....   ||.||:  |.........|::|      .|..|:....:|..|
  Fly   106 VADTQINRKTTLDNPAILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIY 170

Human   141 --VSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKP---------AAGGT 194
              :.|:..||::| .||.|.||..      :|.|.........||.|||:.         :....
  Fly   171 SNLGSVRKEIETL-ELLTDETKIS------ASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEK 228

Human   195 APLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSL-AN---TQPRGP 255
            ..|||..||.|        |.:.|.::.........||...|.....|.|:.: ||   .|....
  Fly   229 DELPPPPSPES--------AVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDAT 285

Human   256 PASSPAPAPKFSPVTPKFTPVASKFSP----GAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTY 316
            ..||......:.|:.|:  |..:...|    .......:..|..:.|...:|....:.| ..:.:
  Fly   286 GKSSSTYDSIYEPINPR--PCVADTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQ-TLYIH 347

Human   317 AQQREKPRVQEKQHPVPPPAQN-----QNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQ 376
            ...|      ...:.|....:|     :|.:..|..|       |:|||...:
  Fly   348 GNAR------TTFYDVNSIHRNDKEGLKNYISIPTEP-------VQELENYGR------------ 387

Human   377 NVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL 441
                   |.:|:..:........|:.|::||.||||..|...|||:.||:|:|.||||..|..||
  Fly   388 -------CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTL 445

Human   442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSV 506
            |||:.|.|||.:|:||||||.|||.|||||||.:.|:|..|.||..|:.:|:.|:||::||||.|
  Fly   446 EKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCV 510

Human   507 CSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571
            |.:||||:||::||:||||||::||::||||||||..||.||:..||:|||.||||:.|:..|.|
  Fly   511 CKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQ 575

Human   572  571
              Fly   576  575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZYX	NP_003452.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..351		76/363 (21%)
		PAT1	<201..>365	CDD:401645	33/176 (19%)
		LIM1_Zyxin	351..437	CDD:188735	26/85 (31%)
		LIM	444..503	CDD:413332	33/58 (57%)
		LIM3_Zyxin	504..570	CDD:188819	41/65 (63%)
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	22/52 (42%)
		LIM2_LPP	448..507	CDD:188740	33/58 (57%)
		LIM3_LPP	508..575	CDD:188821	42/66 (64%)