DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA1S and CCH1

DIOPT Version :9

Sequence 1:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens
Sequence 2:NP_011733.3 Gene:CCH1 / 853131 SGDID:S000003449 Length:2039 Species:Saccharomyces cerevisiae


Alignment Length:1950 Identity:398/1950 - (20%)
Similarity:716/1950 - (36%) Gaps:562/1950 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     9 EGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETI--ILLTIFANCVALAVY 71
            |.|::|...:|.  :|......:|..|  ||||......:..:.:..:  .|||.:|..:|:..|
Yeast   306 ETLQRKLESRPF--VLYGHSLGVFSPT--NPLRIKIARFLLHRRYSLLYNTLLTFYAILLAIRTY 366

Human    72 LPMPEDDNNSLNL--GLEKLEYFFLIV---FSIEAAMKIIAYGF--------------------- 110
            .|     :|.:.|  .....:||..|:   |:.....||||:||                     
Yeast   367 NP-----HNVVFLYRFSNWTDYFIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRS 426

Human   111 -LFHQDAYLRS--GWNVLDFTIVFLGVFTVI-------LEQVNVIQSHTAPMSSK---------- 155
             :.....|||.  |..::||.|    .|.:|       .::.::..|.|.|..:|          
Yeast   427 GIMKLYIYLREKYGRKLIDFII----PFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPR 487

Human   156 --------------------GAGLDVKA------LRAFR---VLRPLRLV---SGVPSLQVVLNS 188
                                |..|.:|:      :|.|:   :||.||||   :|:||   :|..
Yeast   488 AFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRG 549

Human   189 IFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTC-YFIGTDIVATVENE------------ 240
            :...:..|.:::.::::..|.:.|:|:::|:|...:.| :|...|...|.:.:            
Yeast   550 LKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVT 614

Human   241 --------EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDV 297
                    |.........|..|. ..|:|... ..|.:|...|||...||..|:..::...:||:
Yeast   615 KRKQNYIYEDGSEGSVSKGFLCP-QYSKCVSN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDL 677

Human   298 LYWVNDAIGNEW-PWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
            :|:..|:  :|. ..::|:..|.:.:.::|||::.||...|....|:.|.:......|:      
Yeast   678 MYYTMDS--DEMAACLFFIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRK------ 734

Human   362 DLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCH 426
              .||::.|..|                                       :|    :.|:.|.:
Yeast   735 --TGYVARIVTG---------------------------------------YW----KYFKLKAN 754

Human   427 D-----------IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTT--- 477
            .           .:.|.|.:..||||:.                     ||..|..:.:.|:   
Yeast   755 QTKFPNWSQKGLAIYSHVEFIFVILIIC---------------------DIGMRASVKVSTSANC 798

Human   478 -EMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGIS---------------- 525
             .:|:|                     ...||..:|.:||.|...|.:.                
Yeast   799 NNILLK---------------------TDRGISIVLFIESLARLVLYLPNMWKFLTKPSYVYDFI 842

Human   526 ------VLRCIRL----------LRIFKITKYWTSL--SNLVASLLNSIRS----IASLLLLLFL 568
                  |:.|:.:          |.||.|::::..:  .||...|...|.|    |.:|....|.
Yeast   843 ISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQILSNGVMIWNLSSFYFF 907

Human   569 FIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYP 633
            |..:.|::....|.|....|:...:.....:.|.:.:|:|.:.:.|:||.::|  .:....|:..
Yeast   908 FTFLVAIIMAVYFEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWTDILY--ALQKHSPNIS 970

Human   634 GMLVC-IYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGL----PDK 693
            ....| ::|||.|:..|.::||:|:|:          ::.:.:.|.|||:.:::...|    |.|
Yeast   971 STFFCSVFFIIWFLLSNSVILNIFIAL----------ISESMEVKEEEKRPQQIKHYLKFVYPQK 1025

Human   694 SEE-EKSTMAKKLEQK-----------------PKGEGIPTTAKLKIDEFESNVNEVKDPY---P 737
            .:| ..:::..::.:|                 .:|..|...|:        |:.|:.|.:   |
Yeast  1026 IQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQ--------NMGELADEFKEPP 1082

Human   738 SAD-FPGDDEEDEPEIPLSPRPRPLAE-----------------------LQLKE---------K 769
            |.: |.....:....:|...|.|..|.                       |:|.|         |
Yeast  1083 SENLFKKGLSKLTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRTYILELNEYEDEKLDYLK 1147

Human   770 AVPIPEASSFFIFSPTNKIRVLCHRIV----------------------NATWFTN-----FILL 807
            ..|:...|.:| |||.::.|..|.|:|                      ..::|.:     |:.:
Yeast  1148 KYPLFNYSYYF-FSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVFI 1211

Human   808 FILLSSAALAAE---DPIRADSMRNQI-----LKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFC 864
            |.|.:...:...   .|:.  .|.:::     ....|..|...|::|.::|....|......::.
Yeast  1212 FALATILLIVCSCYVTPLY--RMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYL 1274

Human   865 RNYFNMLDLLVVAVSLISMGLESSAI--------SVVKILRVLRVLRPLRAINRAKGLKHVVQCM 921
            ||.:|.:|..|    ||||.:...|.        .:.|.|..||.||.|...|.|:...::|  |
Yeast  1275 RNPWNFIDFCV----LISMWINLIAYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLV--M 1333

Human   922 FVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDG----DPMQ 982
            |..::.|....|::..|.|.|...|:.:|||:...|.| ..:...:|   |..|.:.    |.|.
Yeast  1334 FDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCND-GSLGRADC---YNEYSNSVFQWDIMS 1394

Human   983 IELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFII 1047
            ..:..:.::    |.|:..||..||:.:.:.|||..||...::|:..............|:|.::
Yeast  1395 PRVYQQPYL----HLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVL 1455

Human  1048 YIILIAFFMMNIFVGFVI-----------VTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101
            :..|...|::|:||.|::           .|.:|:...|        :|:...|...||.|....
Yeast  1456 FNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLE--------SQKLLSQAKPKAIPNLIE 1512

Human  1102 IPK-NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEM 1165
            :.: ..:.||:.....:.|:...:..::.|:.|.|..:.||....:.: ..:..:..|.:|.::.
Yeast  1513 LSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGY-QGVYFMFSTSVFLIQE 1576

Human  1166 ILKLMAFKARGYFGDPWNVFDF-LIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESAR 1229
            .|.:.....|.||...||.... :|:|..|::.:...:.   ||....:.:.|            
Yeast  1577 ALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVP---ASHYWFHNIKG------------ 1626

Human  1230 ISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL 1294
                   .|.::..:.::.:.:.:..||.|.:.|...:..:.....:||.:||:...|:||...|
Yeast  1627 -------FFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRL 1684

Human  1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT-CGT-NFA 1357
              |:....|.||:|..:::::||||:.||.|..|:...:   :.:|.........|| ||: .:|
Yeast  1685 --GSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLT---VSEPYCSSDDNSTYTDCGSETYA 1744

Human  1358 YYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDW---SILGPHHLDEFKAIWAEYDPEAKGRIKH 1419
            |...:|:.::..::.:|:||::|:.||.|:.|..   |.:....:.::...|:::|.:..|.::.
Yeast  1745 YLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELEL 1809

Human  1420 LDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFE 1484
            ..:..::.....||.| |....|:..|.||...|.:|.|........|..|              
Yeast  1810 SYLPRIMHSFDGPLSF-KIWEGRLTIKSLVENYMEVNPDDPYDVKIDLIGL-------------- 1859

Human  1485 QANEELRAIIK-KIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRP 1548
              |:||..|.| ||.:|   ||.                 |..|:...|:      ...|.|...
Yeast  1860 --NKELNTIDKAKIIQR---KLQ-----------------YRRFVQSIHY------TNAYNGCIR 1896

Human  1549 KKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLF--GQVDNF 1611
            ..|:: :|..|.|.               .:|.|.|           ||.:....|:  |:||.:
Yeast  1897 FSDLL-LQIPLYTA---------------YSARECL-----------GIDQYVHHLYILGKVDKY 1934

Human  1612 LERTNSLPPVMANQRPLQFAEIEME--------EMESPVFLEDFPQDPRTNPLARANTNNANANV 1668
            ||          |||  .|..:||.        .|:..:..|...:||..:    ::.:|.|.|:
Yeast  1935 LE----------NQR--NFDVLEMVVTRWKFHCRMKRTIEPEWDVKDPTVS----SHISNINVNL 1983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 4/13 (31%)
I. /evidence=ECO:0000305 38..337 86/400 (22%)
Ion_trans 68..345 CDD:278921 79/376 (21%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 3/16 (19%)
II. /evidence=ECO:0000305 418..664 58/299 (19%)
Ion_trans 449..672 CDD:278921 50/265 (19%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 0/2 (0%)
Rib_recp_KP_reg 671..>777 CDD:282899 27/163 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 11/63 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 6/29 (21%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 2/12 (17%)
III. /evidence=ECO:0000305 786..1068 74/339 (22%)
Ion_trans 816..1075 CDD:278921 68/289 (24%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 23/99 (23%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 0/2 (0%)
IV. /evidence=ECO:0000305 1105..1384 60/281 (21%)
Ion_trans 1135..1392 CDD:278921 59/262 (23%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 17/70 (24%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 15/43 (35%)
GPHH 1400..1463 CDD:293510 14/62 (23%)
Ca_chan_IQ 1465..1536 CDD:285917 15/71 (21%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 3/19 (16%)
CAC1F_C <1692..1833 CDD:293490
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780
CCH1NP_011733.3 Ion_trans <483..722 CDD:395416 51/245 (21%)
Ion_trans 769..1010 CDD:395416 59/294 (20%)
Ion_trans 1210..1480 CDD:395416 68/285 (24%)
Ion_trans 1529..1776 CDD:395416 61/274 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 87 1.000 Domainoid score I2034
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 319 1.000 Inparanoid score I518
Isobase 1 0.950 - 0 Normalized mean entropy S2960
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.940

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