DRSC/TRiP Functional Genomics Resources

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Protein Alignment CACNA1S and NaCP60E

DIOPT Version :9

Sequence 1:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2915 Identity:567/2915 - (19%)
Similarity:952/2915 - (32%) Gaps:1247/2915 - (42%)


- Green bases have known domain annotations that are detailed below.


Human    29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFF 93
            ::||.....:|.|:.|:.|...:.|:..::.||..||    ::|.|.|.        :|:.||.|
  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFLAMTET--------VEEAEYIF 156

Human    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAG 158
            |.::|||..:||||.|||.::..|||:.||.|||.::..|..|:.:|..|:            ||
  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL------------AG 209

Human   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223
                 ||.|||||.|:.||.:|.|:.::|::..:...|..:..|.:|.::::|:..|:::.|::.
  Fly   210 -----LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269

Human   224 KTC------------------YFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNH 270
            ..|                  :...||.....|:|.|..|......|.|... ..|......|||
  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVCLCVGENPNH 333

Human   271 GITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPW--IYFVTLILLGSFFILNLVL--- 330
            |.|:||||.:||||.:|.||::.|.:|...|....|   |.  .:|..::..|||:::||:|   
  Fly   334 GYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVV 395

Human   331 ----------------------------------------------------GVLSGEFTKEREK 343
                                                                |||...::|::.:
  Fly   396 ALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTR 460

Human   344 AK----------------SRG---------------------------TFQKLREKQQLDED--- 362
            .|                |.|                           |.|..::.||:::.   
  Fly   461 RKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKL 525

Human   363 ---------------LRGYMSWITQG------EVMDVEDFR------EGKLSLDEGGSDTESLYE 400
                           .:|.:|:...|      .::...|::      .|:.|.:..|.:.||..:
  Fly   526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590

Human   401 IAGL---------------------------------NKIIQFIRHW------------------ 414
            .:|:                                 |..|..|::.                  
  Fly   591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655

Human   415 ---RQWNRIFRWKCHD-------------IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRL 463
               |..:|...| |.|             :|:..:|...:.|.:.|||..:|.|||.........
  Fly   656 LPDRNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNA 719

Human   464 QDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL--LVESGAMTPLGISV 526
            .|:.|:|..|:||.|.::|:..|. :.:|:..:|.||..:|.:.:|:|:  ||:       |:||
  Fly   720 LDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLSV 776

Human   527 LRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY---DFE 588
            ||.:||||:.|:.:.||::..|::.::::|.::.:|.|:|.:.|.|||::|||||...|   .|:
  Fly   777 LRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFD 841

Human   589 DTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCI-YFIILFVCGNYIL 652
            ...|.|.||::|..:.:.:|::|.|| |...:::.:.|   ....|...|. .|:...|.||:::
  Fly   842 PDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMV 902

Human   653 LNVFLAI---------------------------------------------------------- 659
            ||:|||:                                                          
  Fly   903 LNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVL 967

Human   660 ----------------------------------------------------------------- 659
                                                                             
  Fly   968 DAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVD 1032

Human   660 ----------------------------------------------------------------- 659
                                                                             
  Fly  1033 GLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERR 1097

Human   660 ----------------------------------------------------------------- 659
                                                                             
  Fly  1098 LQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRY 1162

Human   660 -------------------------AVDNLAEAESLTSAQKAKAEEKKRRKMSKG---------- 689
                                     ::|.|:::...:.....|:||.:.|:.|.|          
  Fly  1163 GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQ 1227

Human   690 -------------------------LPDKSEEEKSTMAKKL-----EQKPKGE-GIPTTAKLK-- 721
                                     |.::.|.:|.|..:::     .::|..: |.|....:.  
  Fly  1228 DELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEH 1292

Human   722 ------IDEFESNVNEVK--------------DPYPSAD------------FPGDDEE---DEPE 751
                  |..||..:.|:|              :|.|:||            ..|..|.   ||..
  Fly  1293 SEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357

Human   752 IPLSP------------------------------------------------------------ 756
            :||:|                                                            
  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFV 1422

Human   757 ---------------------------------------------------RPRPLAELQL---- 766
                                                               ..:|::.|::    
  Fly  1423 AMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEK 1487

Human   767 -------------------------------KEK------------------------------- 769
                                           |:|                               
  Fly  1488 MPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISS 1552

Human   770 -----------------------AVPIP------------------------------------- 774
                                   |.|.|                                     
  Fly  1553 LKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSA 1617

Human   775 ----------EASS--------------------------------------------------- 778
                      :|||                                                   
  Fly  1618 RTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRR 1682

Human   779 -----------------------------------FFIFSP-------------TNKIRVLCHRI 795
                                               |:...|             ..::|.....:
  Fly  1683 NSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTV 1747

Human   796 VNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKH----FDIGFTSVFTVEIVLKMTTYGA 856
            |:...|..|:|:.|..||..|..|| |..|  :|:.||.    .:..|..:|.||::||....|.
  Fly  1748 VDTPAFEWFVLVLIFASSITLCFED-INLD--KNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809

Human   857 FLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
                ..:..:::.:||.::|.||:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..
  Fly  1810 ----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNA 1870

Human   921 MFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCT----DLSKMTEE----ECRGYYYVYKD 977
            :..||.:|.|::||..:...:|:.:|||.|.||||:|.    :|..:||.    :|....|.   
  Fly  1871 LMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYT--- 1932

Human   978 GDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMA 1042
                        |::|...||:|....::|..|:|||||.:::..|:|:...|:.|.....:...
  Fly  1933 ------------WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985

Human  1043 IFFIIYIILIAFFMMNIFVGFVIVTFQ------EQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101
            |:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|.:  
  Fly  1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-- 2048

Human  1102 IPKNPYQY--QVWYIVTSS-YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTL 1163
            :.|.|..:  .::|.:::| .||..:|.||.||.:.:|::||:|...:..|.::.|..||.:|.|
  Fly  2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113

Human  1164 EMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
            |.|:|::..:.. ||..||||||||:|:.||..:::.:|...|..|..|               .
  Fly  2114 EAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL---------------L 2162

Human  1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA 1293
            |:    .|:||:.|:::|:..|:|:|.||:..:.|..||..:..|:.::.||||::||.:||.:.
  Fly  2163 RV----VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223

Human  1294 LVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKL-CDPESDYAPGE-EYTCG-TN 1355
            |...  ::...|||||.:::.||||..|...|.::|.:...... |||   :..|. ...|| ..
  Fly  2224 LQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHGHTNGNCGHPL 2283

Human  1356 FAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRIKH 1419
            .|..||.||.::...:|||:::|:|::||:...::..| :....|:.|...|::|||.|...|..
  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348

Human  1420 LDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL-KIKTEGNF 1483
            ..:...:..:.||||..|  |:.||   ||..|:|::....:.....|.|||:..| .::...||
  Fly  2349 SQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNF 2408

Human  1484 EQANEELRAIIKK---------------IWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHF 1533
            :|..|::....||               ||||...                     |...||..:
  Fly  2409 KQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGW 2452

Human  1534 RKFMKRQEEYY---------------GYRPK---KDIVQIQAGLRTIEEEAAPEICRTVSGDLAA 1580
            :::::|:.|..               |::.|   .:...:|...|           .|.....|:
  Fly  2453 KEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRR-----------GTACSSRAS 2506

Human  1581 EEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEME----SP 1641
            ..:..||...:.:.|        |.|...|       ||.::.:.......:|:.:..|    ..
  Fly  2507 SRKSSRASDASDLSE--------LAGPWLN-------LPLMLVSGADEVVKDIKQQNDELGKRGS 2556

Human  1642 VFLE------------------DFPQDPRTNP-----LARANTNNANANVAYGNSNHSNSHVFSS 1683
            :|:|                  |...|..|:|     .|..||.|..:|.|      |.|...||
  Fly  2557 IFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSA------STSGTASS 2615

Human  1684 VHYEREFPEETETPAT-------------RGRALG---QPCRVLGP---HSKPCVEMLKGLLTQR 1729
            .         ...|||             |.:|:|   .|.|....   ..||.:|  :||..|.
  Fly  2616 T---------ATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLE--RGLSAQS 2669

Human  1730 AM-PRGQAPPAPCQCPRVESSMPEDRKSSTPGSL--------------HEETPHSRSTRENTSRC 1779
            |: ....|..:....|.|..:.|...:.:.|.||              |.|:...:...|::...
  Fly  2670 ALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSV 2734

Human  1780 SAPATALLIQKALVRGGLGTLAAD--ANFIMATG--QALADACQMEPEEVEIMATELLKGREAPE 1840
            |.......:       ||..|:..  ....:.||  ::..|.|.|  ..|:||..   ..::.|.
  Fly  2735 SGNGNGFGV-------GLDMLSKQPPPQIRITTGSVESSMDTCAM--PTVQIMVD---SPKDPPR 2787

Human  1841 GMASSLGCLNLGSSL-------------------GSLDQHQGSQETL----IPPR 1872
            |..||....::|:.:                   .:.||..|..||.    :|.|
  Fly  2788 GDFSSAPIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDR 2842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 101/373 (27%)
Ion_trans 68..345 CDD:278921 93/351 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 5/40 (13%)
II. /evidence=ECO:0000305 418..664 83/542 (15%)
Ion_trans 449..672 CDD:278921 74/506 (15%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Rib_recp_KP_reg 671..>777 CDD:282899 36/430 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 13/82 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 13/165 (8%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 5/126 (4%)
III. /evidence=ECO:0000305 786..1068 93/294 (32%)
Ion_trans 816..1075 CDD:278921 88/277 (32%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 30/94 (32%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 92/284 (32%)
Ion_trans 1135..1392 CDD:278921 84/259 (32%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 20/69 (29%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 14/42 (33%)
GPHH 1400..1463 CDD:293510 19/62 (31%)
Ca_chan_IQ 1465..1536 CDD:285917 18/86 (21%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 4/19 (21%)
CAC1F_C <1692..1833 CDD:293490 37/178 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 10/63 (16%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/239 (32%)
Ion_trans 705..902 CDD:278921 67/208 (32%)
Ion_trans 1768..2019 CDD:278921 86/272 (32%)
Na_channel_gate 2009..2063 CDD:240441 9/55 (16%)
Ion_trans 2085..2320 CDD:278921 84/259 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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