DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA1S and Ca-alpha1D

DIOPT Version :9

Sequence 1:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens
Sequence 2:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster


Alignment Length:1971 Identity:1026/1971 - (52%)
Similarity:1290/1971 - (65%) Gaps:233/1971 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    12 RKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPE 76
            |:::..||.|:   ||.||||||:::||||..||.||||||||.:|||||||||:|||||.|.|.
  Fly   732 RQQRRGKPQPD---RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPG 793

Human    77 DDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQ 141
            .|:|..|..|||:||.||::|:.|..|||:||||:.|..||||:|||:||||||.:|..:..|.|
  Fly   794 SDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQ 858

Human   142 VNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFM 206
            :           .|.| .||||||||||||||||||||||||||||||.|||:|||||||||||:
  Fly   859 L-----------MKDA-FDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFV 911

Human   207 VIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHG 271
            :|||||||||||.||:||.|    .|.:.....|...||   |.|.:|. .|.:|.|||.|||.|
  Fly   912 IIIYAIIGLELFSGKLHKAC----RDEITGEYEENIRPC---GVGYQCP-PGYKCYGGWDGPNDG 968

Human   272 ITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGE 336
            ||:|||||.:||||:||:|:||||||||.:.||:|::|.|:||:::::||:||::||:|||||||
  Fly   969 ITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGE 1033

Human   337 FTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEI 401
            |:|||.|||:||.|||||||||::||||||:.||||.|  |:|....|.|..|..|.....:...
  Fly  1034 FSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAE--DIEPDAVGGLISDGKGKQPNEMDST 1096

Human   402 AGLNKIIQFIR----HWRQW-------NRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHN 455
            ..|.:.:..::    .||:.       ||..|..|...|||:.||||:|::|.|||..:|:||:.
  Fly  1097 ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYG 1161

Human   456 QPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
            |..||...|:..|...:.|||.|||:|||.||.:.||:|:|||||||||...|.|.||..:|.|.
  Fly  1162 QLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMP 1226

Human   521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY 585
            |||:|||||:||||:||:||||.|||||||||||||:||||||||||||||||||||||:|||::
  Fly  1227 PLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF 1291

Human   586 DFEDTEVR-RSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGN 649
            :|:..|.: |.|||.|.|||::|||::|||||.::||.||.||||.|..|.|.||||||||:|||
  Fly  1292 NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGN 1356

Human   650 YILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGI 714
            ||||||||||||||||:|:||:..:|   ||:..        |:|.::||.     ...|..:|:
  Fly  1357 YILLNVFLAIAVDNLADADSLSEVEK---EEEPH--------DESAQKKSH-----SPTPTIDGM 1405

Human   715 PTTAKLKIDEFESNV-------NEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVP 772
            .....:.||..:..:       :|........:...::||.:.|..::.|||.::|:....|.:|
  Fly  1406 DDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILP 1470

Human   773 IPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDI 837
            ||..:|||:||.||:.||.||.:.|.:.|.|.||..|:.|||.||||:|:||:...|::|..||.
  Fly  1471 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDY 1535

Human   838 GFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVL 902
            .||:|||:|::||:.:||..||.|:|||:.||:||||||.|||||:...|:||||||||||||||
  Fly  1536 FFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVL 1600

Human   903 RPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFA------------C----------- 944
            ||||||||||||||||||:.||:.|||||||||.|||||||            |           
  Fly  1601 RPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNI 1665

Human   945 -------------IGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFH 996
                         |||||||||||:|||.||||::||.|.|.||.|||..:..||.|||.::.||
  Fly  1666 MLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFH 1730

Human   997 FDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFV 1061
            ||:|...|::|||||||||||.|||.:||||.|:.|||:|.|..:|.::|||||:|||||:||||
  Fly  1731 FDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFV 1795

Human  1062 GFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFA 1126
            ||||||||.:||.|||||:||||||.|:::||||:|:|.||||:..||:||:.||||.|||.:|.
  Fly  1796 GFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFI 1860

Human  1127 LIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVI 1191
            |||:||:.|.|:.|||......:.|.||:.||.:|.||.:.||.||:.:.||||.||||||:||:
  Fly  1861 LIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVL 1925

Human  1192 GSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESAR-ISSAFFRLFRVMRLIKLLSRAEGVRT 1255
            ||.||::.|||.:...|......:..||.:......:. ||..||||||||||:||||:.||:||
  Fly  1926 GSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRT 1990

Human  1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA 1320
            ||||||||||||||||||||:|||||||:|||:||||||..|..|..|||||||.||||:|||.|
  Fly  1991 LLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSA 2055

Human  1321 TGEAWQEILLACSY--GKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDN 1383
            ||||||||:::||.  ...||..|| .|||  .||::.||.||||||:||:||:|||||||||||
  Fly  2056 TGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDN 2117

Human  1384 FDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRL 1448
            |||||||||||||||||||..:|:||||:|||||||||||||||:|.|||||||.||||:|||||
  Fly  2118 FDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRL 2182

Human  1449 VGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPI 1513
            |.|||||||||||.|||||||:|||:|.|||:||.:.||.||||.||:|||||:.||||||:||.
  Fly  2183 VSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPP 2247

Human  1514 G-DDEVTVGKFYATFLIQEHFRKFMKR--QEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVS 1575
            | ||||||||||||:|||::||:|.||  ||...|: |..:.|.:||||||: .|.:|.:.|.:|
  Fly  2248 GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGH-PDSNTVTLQAGLRTL-HEVSPALKRAIS 2310

Human  1576 GDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEIEMEEMES 1640
            |:|   :||::.      .|.:.||...|||.|.:.:.|..                       :
  Fly  2311 GNL---DELDQE------PEPMHRRHHTLFGSVWSSIRRHG-----------------------N 2343

Human  1641 PVFLEDFPQDPRTNPLARANTNNA------------------------------------NANVA 1669
            ..|        |.:..|.|:.:|.                                    |.:||
  Fly  2344 GTF--------RRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVA 2400

Human  1670 YGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRVLGP--HSKPCVEMLKGLLTQRAMP 1732
            .|.:|.:.:.:.:.:....:..:|.:     |...|...|..|.  ..:|..:...|..|    .
  Fly  2401 DGVNNITRNIMQARLAAAGKLQDELQ-----GAGSGGELRTFGESISMRPLAKNGGGAAT----V 2456

Human  1733 RGQAPP-----------------------APCQCPRVESSMP--EDRKSSTPGSLHEETPHSRST 1772
            .|..||                       ||      ..::|  |....|||.|     |:.:..
  Fly  2457 AGTLPPEANAINYDNRNRGILLHPYNNVYAP------NGALPGHERMIQSTPAS-----PYDQRR 2510

Human  1773 RENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKGRE 1837
            ...:|..:..|.: ||...|...|||.. .|:.|:....:.:.:|..|.|||:.:.|.::|....
  Fly  2511 LPTSSDMNGLAES-LIGGVLAAEGLGKY-CDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEH 2573

Human  1838 APEGMASSLGCLNLGSSLGSL 1858
            :...:.||.|.: .|.|.|.|
  Fly  2574 SLSLIGSSNGSI-FGGSAGGL 2593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 4/10 (40%)
I. /evidence=ECO:0000305 38..337 185/298 (62%)
Ion_trans 68..345 CDD:278921 167/276 (61%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 12/16 (75%)
II. /evidence=ECO:0000305 418..664 162/246 (66%)
Ion_trans 449..672 CDD:278921 152/223 (68%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 2/2 (100%)
Rib_recp_KP_reg 671..>777 CDD:282899 23/112 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 4/25 (16%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 4/12 (33%)
III. /evidence=ECO:0000305 786..1068 188/317 (59%)
Ion_trans 816..1075 CDD:278921 179/294 (61%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 59/88 (67%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 170/281 (60%)
Ion_trans 1135..1392 CDD:278921 161/259 (62%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 50/65 (77%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 31/41 (76%)
GPHH 1400..1463 CDD:293510 52/62 (84%)
Ca_chan_IQ 1465..1536 CDD:285917 53/71 (75%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 14/21 (67%)
CAC1F_C <1692..1833 CDD:293490 36/167 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 13/73 (18%)
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 182/294 (62%)
Ion_trans 1137..1379 CDD:395416 162/241 (67%)
Ion_trans 1496..1809 CDD:395416 187/312 (60%)
Ion_trans 1851..2126 CDD:395416 172/277 (62%)
GPHH 2135..2188 CDD:407139 42/52 (81%)
Ca_chan_IQ 2199..2271 CDD:400901 53/71 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 383 1.000 Domainoid score I825
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1991 1.000 Inparanoid score I55
Isobase 1 0.950 - 0 Normalized mean entropy S2960
OMA 1 1.010 - - QHG48156
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 1 1.000 - - otm41149
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 1 1.000 - - X533
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.960

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