DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA1S and cch1

DIOPT Version :9

Sequence 1:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens
Sequence 2:NP_593894.1 Gene:cch1 / 2542812 PomBaseID:SPAC6F6.01 Length:1854 Species:Schizosaccharomyces pombe


Alignment Length:2042 Identity:399/2042 - (19%)
Similarity:740/2042 - (36%) Gaps:627/2042 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    27 PPRALFCLTLENPLRKACISIVEWKPFETIIL---------LTIFANCVALAVYLPMPEDDNNSL 82
            ||||     .|.|.|..        ||..|:.         :.||...|..||.|.:..||.:..
pombe   161 PPRA-----NETPGRNL--------PFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDK 212

Human    83 NLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQD------------------AYLRSGWNVLDFTI 129
            :..::.|.....|::::|..:||..:|||:...                  :|||..||.:||. 
pombe   213 SQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFV- 276

Human   130 VFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV---LRPLRLVSGVPSLQVVLNSIFK 191
                  .::...::||       ..|..|:    .|.|.:   ||..||::.....:.:|.|:.:
pombe   277 ------AIVALWISVI-------GKKQQGI----FRLFSMIACLRLTRLLNITRKTETILKSLKE 324

Human   192 AMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTI 256
            :..||..:.....|..::.||:|::.||..:::.|.::|                  ..|.:...
pombe   325 SSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLG------------------DYGDQYLP 371

Human   257 NGSECRGGW----------------------------------PGPNHGITHFDNFGFSMLTVYQ 287
            .|..|.|.|                                  ..|......||||..|:..::.
pombe   372 TGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFV 436

Human   288 CITMEGWTDVLYWVNDAIGNEWPWIYFVT--LILLGSFF----ILNLVLGVLSGEFTKEREKAKS 346
            .::..|:||::|.:.||       .|||:  |.::.::|    :::||:.|::..|...:...|:
pombe   437 IMSSNGFTDIMYDIMDA-------EYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKN 494

Human   347 RGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
            :      :|::.:|:.|                                               |
pombe   495 Q------KEQKSVDKHL-----------------------------------------------I 506

Human   412 RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLL---- 472
            |     |::    |...:....|.|:..::....||  .::.::|      ....|||.|:    
pombe   507 R-----NKL----CEKYLFYSNFIWISFIVAQFVTL--CTQTYDQ------TSSTANRYLIFYAC 554

Human   473 --SLFTTEMLMKMYGL--GLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG---ISVLRCI 530
              .|...|::::.:..  ..|.:|....|..|  :|.:.:..:.|:.|....|:.   :|:....
pombe   555 VDFLLAAEVILRFFAYLPDYRLFFRRYTNLVD--IVLAVLNLVTLLPSIRKNPVAFGWLSIFAIA 617

Human   531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRS 595
            |:.|...:..|...::.|   |.::.:.:.:|:|.|.:.:.|.:|..::||....:..|::....
pombe   618 RIYRCILLIPYTRKIAKL---LFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAI 679

Human   596 NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
            :|....::.:.::|:||.|:||.:|: .|.|.....:...:...:|.:.|:..|.::|::|:|:.
pombe   680 SFATTYESFLYMYQILTSENWTDVMF-AIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVI 743

Human   661 VDNLAEAESLTSAQKAKAEEK-------------------KRRKMSKG-LPDKSEEE-------- 697
            ..|.|.:||....::.|....                   ||....|| ..|:|..|        
pombe   744 QVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNII 808

Human   698 -----KSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEV---KDPYPSADFP---GDDEEDEPE 751
                 .:.:..|...||..:..|..:|..:.:..:|....   .||:..|.|.   |...|.:..
pombe   809 KGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDMN 873

Human   752 IPLSPRPRPLAELQLKEKAVPI----PEASS-FFIFSPTNKIRVLCHRIVNA------------T 799
            :..:.:....|:..::.|....    |:.:. |::..|:|:||..|.|:|..            .
pombe   874 LKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRLVMPGVNERYGGVEPYQ 938

Human   800 WFTNFILLFI---LLSSAAL-AAEDPI-RADSMRNQILKH-----FDIGFTSVFTVEIVLKMTTY 854
            |....|.:||   :|::..: ....|| ..|.:.|. .:|     .::.|.::||:|..:|:...
pombe   939 WVYRVIQVFIYACILTAVIIECIATPIYERDHLLND-KQHAWFVWTEVAFATIFTIEAAIKIIAD 1002

Human   855 GAFLHKGSFCRNYFNMLDLLVVAVSLISM--GLESSAISVVKILRVLRVLRPLRAINRAKGLKHV 917
            |..:...::.|:.:|.:|..|:....|::  .|.|.|: :.:..|..:.||.||.||    |...
pombe  1003 GFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHAL-LSRAFRAFKALRVLRLIN----LTQT 1062

Human   918 VQCMF--VAIS---TIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKD 977
            .|.||  ..||   .|.:..:|:..|...||.....:|.|..:.|.|.:.::..:|...|    .
pombe  1063 SQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSCNDDNVLSASQCVLEY----A 1123

Human   978 GDPMQIEL-RHREWVH-SDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVE 1040
            ..|...|: ..|.|.: .|:.||....|:::||.:::.|||..::...:|....:..|..|....
pombe  1124 STPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSG 1188

Human  1041 MAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLR------ 1099
            .|:||:::.::...:::.:|:..:|..:.|:..:.:...|    ||..::...|.:.:|      
pombe  1189 NAMFFVLFNLVSMIYILTLFIAIIISNYAERTGSAFFTAE----QRAWLELRRKIKSMRPSKRPA 1249

Human  1100 ---------CY---IPKNPYQYQVW-YIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISD 1151
                     ||   :.|    :.:| ...|..|..:|:|.|.:.         |.......::.:
pombe  1250 IRPLGLRGLCYDFAVQK----HGIWRRTFTGLYIVHLLFLLTIF---------YPCPIAYTYVRN 1301

Human  1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII--DVILSEID----TFLASSG 1210
            .:.:..:|.:|:.:.:|:.......:|...||:||.::.:||:.  ..||::.:    |.|.:: 
pombe  1302 SIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSLTLLQTT- 1365

Human  1211 GLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI- 1274
                                       ..|:..:.|:.:.:....|..|.:.|   ||.:..|| 
pombe  1366 ---------------------------LLVLVTVHLIPKFDNFDQLSKTVVAS---LPSIFSLIA 1400

Human  1275 --VMLFFIYAVIGMQMFG--KIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIL--LACS 1333
              ::|:..:|:...|:||  |:.|..|.    |.||::...|::|||....||.|.:::  ...|
pombe  1401 TWIVLYITFAIAFNQIFGLTKLGLNGGP----NKNFRSIRNALVLLFTMTFGEGWNDVMHDYTIS 1461

Human  1334 YGKLCDPESDYAPGEEYTCGTN-FAYYYFISFYMLCAFLVINLFVAVIMDNFDYL-TRDWSILGP 1396
            |....:.:..|    ...||.. :||..||::.::..::.:|:|:.|:.|||.|: |:..|....
pombe  1462 YPNCVNGDDFY----NSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNL 1522

Human  1397 HHLD--EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDG 1459
            ...|  :||..||.:||...|                      :.|.|.|               
pombe  1523 QRNDFRQFKDSWAPFDPMVTG----------------------YIPKRNA--------------- 1550

Human  1460 TVTFNATLFALVRTALKIKTEGNFEQANEE--LRAIIKKIWKRT-----------------SMKL 1505
                       |:..|.::...:|....:|  ||:||.|:..:|                 :::.
pombe  1551 -----------VKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEA 1604

Human  1506 LDQVIPPIGDDEVTVGK---------------------FYATFLIQEHFRKFMKRQEEYYGYRPK 1549
            |||:|..|   :|.|.|                     .::..|:.....|.:..:|.:    |.
pombe  1605 LDQIIDTI---DVNVVKERRNVLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAF----PI 1662

Human  1550 KDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLER 1614
            .|.::                               ||.|.:.:|:.|  |...|.|.|:..:.|
pombe  1663 SDYIR-------------------------------RAYVLSELEKSI--RMEKLLGLVETSIIR 1694

Human  1615 TNSLPPVMANQRPLQFAEIEMEEMESPVFL-----EDFPQDPRTNPLARANTNNANANVAYGNSN 1674
            ...          ||..|.:.:.:|:|..|     |..|:.|....|.:.|.:            
pombe  1695 KTF----------LQHMEEKKKALENPFILLSEVSEILPETPIQEVLRQHNAD------------ 1737

Human  1675 HSNSHVFSSVHYEREFPEE----TETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQ 1735
                            ||:    |.||:...|:..            .||               
pombe  1738 ----------------PEQLLMSTRTPSVSDRSFS------------IVE--------------- 1759

Human  1736 APPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRG----- 1795
                 ...|.:.|...:|.        |....|.:...:|..|.| |:    :::.|:||     
pombe  1760 -----STVPTIASGEGDDN--------HSVEDHLKVPTDNEPRRS-PS----LKEVLLRGSHSLH 1806

Human  1796 ------------GLGTLAADANFIMAT 1810
                        |.||..:|..|..||
pombe  1807 SNNDRTSFDIEAGFGTAESDFQFGGAT 1833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 75/368 (20%)
Ion_trans 68..345 CDD:278921 68/337 (20%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 2/16 (13%)
II. /evidence=ECO:0000305 418..664 51/256 (20%)
Ion_trans 449..672 CDD:278921 49/233 (21%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Rib_recp_KP_reg 671..>777 CDD:282899 23/148 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 12/74 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 6/31 (19%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 1/12 (8%)
III. /evidence=ECO:0000305 786..1068 75/312 (24%)
Ion_trans 816..1075 CDD:278921 65/274 (24%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 20/89 (22%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 0/2 (0%)
IV. /evidence=ECO:0000305 1105..1384 61/293 (21%)
Ion_trans 1135..1392 CDD:278921 59/271 (22%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 17/69 (25%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 14/43 (33%)
GPHH 1400..1463 CDD:293510 11/64 (17%)
Ca_chan_IQ 1465..1536 CDD:285917 19/110 (17%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 3/40 (8%)
CAC1F_C <1692..1833 CDD:293490 26/140 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 7/48 (15%)
cch1NP_593894.1 Ion_trans 201..485 CDD:278921 65/326 (20%)
Ion_trans 533..748 CDD:278921 47/228 (21%)
Ion_trans 968..1220 CDD:278921 63/261 (24%)
Ion_trans 1289..1517 CDD:278921 59/275 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 83 1.000 Domainoid score I2557
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.940

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