DRSC/TRiP Functional Genomics Resources

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Protein Alignment CACNA1S and cch1

DIOPT Version :10

Sequence 1:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens
Sequence 2:NP_593894.1 Gene:cch1 / 2542812 PomBaseID:SPAC6F6.01 Length:1854 Species:Schizosaccharomyces pombe


Alignment Length:2042 Identity:399/2042 - (19%)
Similarity:740/2042 - (36%) Gaps:627/2042 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    27 PPRALFCLTLENPLRKACISIVEWKPFETIIL---------LTIFANCVALAVYLPMPEDDNNSL 82
            ||||     .|.|.|..        ||..|:.         :.||...|..||.|.:..||.:..
pombe   161 PPRA-----NETPGRNL--------PFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDK 212

Human    83 NLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQD------------------AYLRSGWNVLDFTI 129
            :..::.|.....|::::|..:||..:|||:...                  :|||..||.:||. 
pombe   213 SQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFV- 276

Human   130 VFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRV---LRPLRLVSGVPSLQVVLNSIFK 191
                  .::...::||       ..|..|:    .|.|.:   ||..||::.....:.:|.|:.:
pombe   277 ------AIVALWISVI-------GKKQQGI----FRLFSMIACLRLTRLLNITRKTETILKSLKE 324

Human   192 AMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTI 256
            :..||..:.....|..::.||:|::.||..:::.|.::|                  ..|.:...
pombe   325 SSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLG------------------DYGDQYLP 371

Human   257 NGSECRGGW----------------------------------PGPNHGITHFDNFGFSMLTVYQ 287
            .|..|.|.|                                  ..|......||||..|:..::.
pombe   372 TGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFV 436

Human   288 CITMEGWTDVLYWVNDAIGNEWPWIYFVT--LILLGSFF----ILNLVLGVLSGEFTKEREKAKS 346
            .::..|:||::|.:.||       .|||:  |.::.::|    :::||:.|::..|...:...|:
pombe   437 IMSSNGFTDIMYDIMDA-------EYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKN 494

Human   347 RGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
            :      :|::.:|:.|                                               |
pombe   495 Q------KEQKSVDKHL-----------------------------------------------I 506

Human   412 RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLL---- 472
            |     |::    |...:....|.|:..::....||  .::.::|      ....|||.|:    
pombe   507 R-----NKL----CEKYLFYSNFIWISFIVAQFVTL--CTQTYDQ------TSSTANRYLIFYAC 554

Human   473 --SLFTTEMLMKMYGL--GLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG---ISVLRCI 530
              .|...|::::.:..  ..|.:|....|..|  :|.:.:..:.|:.|....|:.   :|:....
pombe   555 VDFLLAAEVILRFFAYLPDYRLFFRRYTNLVD--IVLAVLNLVTLLPSIRKNPVAFGWLSIFAIA 617

Human   531 RLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRS 595
            |:.|...:..|...::.|   |.::.:.:.:|:|.|.:.:.|.:|..::||....:..|::....
pombe   618 RIYRCILLIPYTRKIAKL---LFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAI 679

Human   596 NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
            :|....::.:.::|:||.|:||.:|: .|.|.....:...:...:|.:.|:..|.::|::|:|:.
pombe   680 SFATTYESFLYMYQILTSENWTDVMF-AIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVI 743

Human   661 VDNLAEAESLTSAQKAKAEEK-------------------KRRKMSKG-LPDKSEEE-------- 697
            ..|.|.:||....::.|....                   ||....|| ..|:|..|        
pombe   744 QVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNII 808

Human   698 -----KSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEV---KDPYPSADFP---GDDEEDEPE 751
                 .:.:..|...||..:..|..:|..:.:..:|....   .||:..|.|.   |...|.:..
pombe   809 KGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDMN 873

Human   752 IPLSPRPRPLAELQLKEKAVPI----PEASS-FFIFSPTNKIRVLCHRIVNA------------T 799
            :..:.:....|:..::.|....    |:.:. |::..|:|:||..|.|:|..            .
pombe   874 LKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRLVMPGVNERYGGVEPYQ 938

Human   800 WFTNFILLFI---LLSSAAL-AAEDPI-RADSMRNQILKH-----FDIGFTSVFTVEIVLKMTTY 854
            |....|.:||   :|::..: ....|| ..|.:.|. .:|     .::.|.::||:|..:|:...
pombe   939 WVYRVIQVFIYACILTAVIIECIATPIYERDHLLND-KQHAWFVWTEVAFATIFTIEAAIKIIAD 1002

Human   855 GAFLHKGSFCRNYFNMLDLLVVAVSLISM--GLESSAISVVKILRVLRVLRPLRAINRAKGLKHV 917
            |..:...::.|:.:|.:|..|:....|::  .|.|.|: :.:..|..:.||.||.||    |...
pombe  1003 GFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHAL-LSRAFRAFKALRVLRLIN----LTQT 1062

Human   918 VQCMF--VAIS---TIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKD 977
            .|.||  ..||   .|.:..:|:..|...||.....:|.|..:.|.|.:.::..:|...|    .
pombe  1063 SQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSCNDDNVLSASQCVLEY----A 1123

Human   978 GDPMQIEL-RHREWVH-SDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVE 1040
            ..|...|: ..|.|.: .|:.||....|:::||.:::.|||..::...:|....:..|..|....
pombe  1124 STPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSG 1188

Human  1041 MAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLR------ 1099
            .|:||:::.::...:::.:|:..:|..:.|:..:.:...|    ||..::...|.:.:|      
pombe  1189 NAMFFVLFNLVSMIYILTLFIAIIISNYAERTGSAFFTAE----QRAWLELRRKIKSMRPSKRPA 1249

Human  1100 ---------CY---IPKNPYQYQVW-YIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISD 1151
                     ||   :.|    :.:| ...|..|..:|:|.|.:.         |.......::.:
pombe  1250 IRPLGLRGLCYDFAVQK----HGIWRRTFTGLYIVHLLFLLTIF---------YPCPIAYTYVRN 1301

Human  1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII--DVILSEID----TFLASSG 1210
            .:.:..:|.:|:.:.:|:.......:|...||:||.::.:||:.  ..||::.:    |.|.:: 
pombe  1302 SIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSLTLLQTT- 1365

Human  1211 GLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI- 1274
                                       ..|:..:.|:.:.:....|..|.:.|   ||.:..|| 
pombe  1366 ---------------------------LLVLVTVHLIPKFDNFDQLSKTVVAS---LPSIFSLIA 1400

Human  1275 --VMLFFIYAVIGMQMFG--KIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIL--LACS 1333
              ::|:..:|:...|:||  |:.|..|.    |.||::...|::|||....||.|.:::  ...|
pombe  1401 TWIVLYITFAIAFNQIFGLTKLGLNGGP----NKNFRSIRNALVLLFTMTFGEGWNDVMHDYTIS 1461

Human  1334 YGKLCDPESDYAPGEEYTCGTN-FAYYYFISFYMLCAFLVINLFVAVIMDNFDYL-TRDWSILGP 1396
            |....:.:..|    ...||.. :||..||::.::..::.:|:|:.|:.|||.|: |:..|....
pombe  1462 YPNCVNGDDFY----NSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNL 1522

Human  1397 HHLD--EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDG 1459
            ...|  :||..||.:||...|                      :.|.|.|               
pombe  1523 QRNDFRQFKDSWAPFDPMVTG----------------------YIPKRNA--------------- 1550

Human  1460 TVTFNATLFALVRTALKIKTEGNFEQANEE--LRAIIKKIWKRT-----------------SMKL 1505
                       |:..|.::...:|....:|  ||:||.|:..:|                 :::.
pombe  1551 -----------VKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEA 1604

Human  1506 LDQVIPPIGDDEVTVGK---------------------FYATFLIQEHFRKFMKRQEEYYGYRPK 1549
            |||:|..|   :|.|.|                     .::..|:.....|.:..:|.:    |.
pombe  1605 LDQIIDTI---DVNVVKERRNVLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAF----PI 1662

Human  1550 KDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLER 1614
            .|.::                               ||.|.:.:|:.|  |...|.|.|:..:.|
pombe  1663 SDYIR-------------------------------RAYVLSELEKSI--RMEKLLGLVETSIIR 1694

Human  1615 TNSLPPVMANQRPLQFAEIEMEEMESPVFL-----EDFPQDPRTNPLARANTNNANANVAYGNSN 1674
            ...          ||..|.:.:.:|:|..|     |..|:.|....|.:.|.:            
pombe  1695 KTF----------LQHMEEKKKALENPFILLSEVSEILPETPIQEVLRQHNAD------------ 1737

Human  1675 HSNSHVFSSVHYEREFPEE----TETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQ 1735
                            ||:    |.||:...|:..            .||               
pombe  1738 ----------------PEQLLMSTRTPSVSDRSFS------------IVE--------------- 1759

Human  1736 APPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRG----- 1795
                 ...|.:.|...:|.        |....|.:...:|..|.| |:    :::.|:||     
pombe  1760 -----STVPTIASGEGDDN--------HSVEDHLKVPTDNEPRRS-PS----LKEVLLRGSHSLH 1806

Human  1796 ------------GLGTLAADANFIMAT 1810
                        |.||..:|..|..||
pombe  1807 SNNDRTSFDIEAGFGTAESDFQFGGAT 1833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 75/368 (20%)
Ion_trans 50..345 CDD:459842 74/364 (20%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 2/16 (13%)
II. /evidence=ECO:0000305 418..664 51/256 (20%)
Ion_trans 431..672 CDD:459842 53/251 (21%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 12/74 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 6/31 (19%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 1/12 (8%)
III. /evidence=ECO:0000305 786..1068 75/312 (24%)
Ion_trans 798..1075 CDD:459842 70/307 (23%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 20/89 (22%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 0/2 (0%)
IV. /evidence=ECO:0000305 1105..1384 61/293 (21%)
Ion_trans 1117..1392 CDD:459842 63/289 (22%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 17/69 (25%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 14/43 (33%)
GPHH 1401..1454 CDD:465306 10/52 (19%)
Ca_chan_IQ 1464..1536 CDD:462591 19/111 (17%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 3/40 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 7/48 (15%)
cch1NP_593894.1 Ion_trans 184..485 CDD:459842 70/343 (20%)
Ion_trans 514..748 CDD:459842 50/247 (20%)
Ion_trans 941..1220 CDD:459842 69/288 (24%)
Ion_trans 1267..1517 CDD:459842 65/297 (22%)
Blue background indicates that the domain is not in the aligned region.

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