DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZXDA and Zxdb

DIOPT Version :9

Sequence 1:	NP_009087.1	Gene:	ZXDA / 7789	HGNCID:	13198	Length:	799	Species:	Homo sapiens
Sequence 2:	NP_001074942.1	Gene:	Zxdb / 668166	MGIID:	3694898	Length:	873	Species:	Mus musculus

Alignment Length:	876	Identity:	649/876 - (74%)
Similarity:	691/876 - (78%)	Gaps:	80/876 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLPRGPQDGGPGRRREEASTA 65
            ||||:|||||||.||.||||.|||||.|||.|.|.|.|.|||||||.||.||||||.|..||..|
Mouse     1 MEIPRLLPARGTPQGAGGGGCPAGGGGVHRAPASLACQAPTRRLLLLRGAQDGGPGPRSAEAQRA 65

Human    66 SRGPGPSL--FAPRP-HQPSGGG-----------------------------------DDFFLVL 92
            |||.||||  .|||| |:.||||                                   |||||:|
Mouse    66 SRGLGPSLNRLAPRPDHRSSGGGRGGGAGGGGGGSGGGGGGGGGGGGGGGGGGSRGGSDDFFLLL 130

Human    93 LDPVGGDVETAGSGQAAGPVLREEAKAGPGLQGDESGANPAGCSAQGPHCLSAVP--TPAPISAP 155
            ||||||||||.|:.||..||.||||.|||..:..:|...|||....||.||||||  :|.|.:.|
Mouse   131 LDPVGGDVETVGTEQAGAPVRREEAGAGPRPERRQSAGPPAGRPEPGPRCLSAVPAASPLPAAGP 195

Human   156 GP--------AAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPR------CLIA 206
            ||        |||||||:||||||||||||||||||.|||..|||||.||..||:      .|||
Mouse   196 GPAAAAAAAAAAAFAGTITIHNQDLLLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIA 260

Human   207 PQ---AGFPQA-----------AHPGDCPELRSDLLLAEPAEPAPAPAPQE---EAEGLAAALGP 254
            ||   ||||.|           |..||||||..|||||||||||..|||.|   ||...|||..|
Mouse   261 PQAAAAGFPPAAAAAAAAAAAGAQLGDCPELPPDLLLAEPAEPAACPAPPEEEAEAPAAAAAQSP 325

Human   255 RGLL--GSGPGVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKL 317
            ||..  |.||||||||||||.||||||||||||:||||||||||||||||||.||||||||||||
Mouse   326 RGPAGPGPGPGVVLYLCPEAQCGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLSGCGWTFTTSYKL 390

Human   318 KRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLGAHQRSH 382
            ||||||||||||||||.:||||||||||||||||||||||||||||||||||||||||..|||||
Mouse   391 KRHLQSHDKLRPFGCPVQGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLSTHQRSH 455

Human   383 FEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGE 447
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   456 FEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFACSFPGCSKQYDKACRLKIHLRSHTGE 520

Human   448 RPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVC 512
            |||||||||||||||||||||||||||:|||||.|||||||||||||||||||||||||||||||
Mouse   521 RPFLCDFDGCGWNFTSMSKLLRHKRKHEDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFVC 585

Human   513 PVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQ 577
            ||.|||||||||||||||||||||||..||||||:.:|||||||||||||||.|||.:.||||||
Mouse   586 PVEGCCARFSARSSLYIHSKKHLQDVGAWKSRCPVPTCNKLFTSKHSMKTHMTKRHNLSQDLLAQ 650

Human   578 LEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAG 642
            |||||||||||||||..|:|||.||:||||||||...|||:||||||||||||||||||:|:|||
Mouse   651 LEAANSLTPSSELTSPGQSDLSGAELVSLFSDVPGHGSAAVLDTALVNSGILTIDVASVNSSLAG 715

Human   643 HLPA---NNNNSVGQAVDPPSLM-ATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLG 703
            .|||   :||:|:|||.:|.:|. |.||.||||||||||||:..|:|.|.|:||:||:.:||..|
Mouse   716 SLPADNNSNNHSLGQAAEPRALRGAPSDLPQSLDTSLFFGTSVAGYQHSPLDMDDVSAGNVGLFG 780

Human   704 SLDSLAMKNSSPEPQALTPSSKLTVDTDTLTPSSTLCENSVSELLTPAKAEWSVHPNSDFFGQEG 768
               |||:||||.||||||||:||||||:.|||||||||||||||||||||||:|||.|||||.|.
Mouse   781 ---SLALKNSSLEPQALTPSNKLTVDTEALTPSSTLCENSVSELLTPAKAEWNVHPESDFFGHEE 842

Human   769 ETQFGFPNAAGNHGSQKERNLITVTGSSFLV 799
            ||||||.:..|:|||||:.:||||||:.|||
Mouse   843 ETQFGFSHPTGSHGSQKDTDLITVTGTPFLV 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZXDA	NP_009087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89		66/125 (53%)
		Required for interaction with ZXDC. /evidence=ECO:0000269\|PubMed:17493635	267..573		285/305 (93%)
		C2H2 Zn finger	269..291	CDD:275368	19/21 (90%)
		zf-C2H2_aberr	300..445	CDD:293622	138/144 (96%)
		zf-C2H2	300..324	CDD:278523	22/23 (96%)
		C2H2 Zn finger	302..324	CDD:275368	20/21 (95%)
		C2H2 Zn finger	332..354	CDD:275368	19/21 (90%)
		zf-H2C2_2	346..369	CDD:290200	22/22 (100%)
		C2H2 Zn finger	362..382	CDD:275368	17/19 (89%)
		C2H2 Zn finger	391..413	CDD:275368	21/21 (100%)
		C2H2 Zn finger	425..444	CDD:275368	18/18 (100%)
		COG5048	<437..568	CDD:227381	121/130 (93%)
		C2H2 Zn finger	452..474	CDD:275368	21/21 (100%)
		zf-H2C2_2	467..493	CDD:290200	23/25 (92%)
		C2H2 Zn finger	482..504	CDD:275368	21/21 (100%)
		C2H2 Zn finger	512..534	CDD:275370	20/21 (95%)
		Required for transcriptional activation	572..699		94/130 (72%)
Zxdb	NP_001074942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		17/21 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..120		28/71 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..184		24/45 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..330		16/28 (57%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	340..646		285/305 (93%)
		C2H2 Zn finger	342..364	CDD:275368	19/21 (90%)
		zf-C2H2_aberr	373..518	CDD:293622	138/144 (96%)
		C2H2 Zn finger	375..397	CDD:275368	20/21 (95%)
		C2H2 Zn finger	405..427	CDD:275368	19/21 (90%)
		zf-H2C2_2	419..442	CDD:290200	22/22 (100%)
		C2H2 Zn finger	435..455	CDD:275368	17/19 (89%)
		C2H2 Zn finger	464..486	CDD:275368	21/21 (100%)
		C2H2 Zn finger	498..517	CDD:275368	18/18 (100%)
		COG5048	<510..642	CDD:227381	122/131 (93%)
		C2H2 Zn finger	525..547	CDD:275368	21/21 (100%)
		C2H2 Zn finger	555..577	CDD:275368	21/21 (100%)
		C2H2 Zn finger	585..607	CDD:275370	20/21 (95%)
		Required for transcriptional activation. /evidence=ECO:0000250	645..776		94/130 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I9624
eggNOG	1	0.900	-	-		E33208_3BGAZ
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1285	1.000	Inparanoid score	I3902
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG38029
OrthoDB	1	1.010	-	-		D140175at7742
OrthoFinder	1	1.000	-	-		FOG0006889
OrthoInspector	1	1.000	-	-		otm51642
orthoMCL	1	0.900	-	-		OOG6_108814
Panther	1	1.100	-	-	O	PTHR46179
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	14.340