DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K12 and YPL150W

DIOPT Version :9

Sequence 1:	NP_001180440.1	Gene:	MAP3K12 / 7786	HGNCID:	6851	Length:	892	Species:	Homo sapiens
Sequence 2:	NP_015175.1	Gene:	YPL150W / 855953	SGDID:	S000006071	Length:	901	Species:	Saccharomyces cerevisiae

Alignment Length:	896	Identity:	194/896 - (21%)
Similarity:	332/896 - (37%)	Gaps:	205/896 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   133 TMIGKAYSTEHKQ-QQEDLWEVPFEEILDLQWVGSGAQGAVFLG--RFHGEEVAVKK-------- 186
            ::||.:|:..:.| ..::|.||...:|  |:.:|.|:.|.|:|.  |....:|.:|.
Yeast    17 SIIGSSYNRLYSQFTSDELTEVGNYKI--LKQIGEGSFGKVYLALHRPTHRKVCLKTSDKNDPNI 79

Human   187 VRDL---KETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVD 248
            ||::   ::.|..::.||       ::.:.|::..: :.:|:|...:||:.|.:.|.::.....:
Yeast    80 VREVFYHRQFDFPYITKL-------YEVIVTESKVW-MALEYCPGKELYDHLLSLRRISLLECGE 136

Human   249 WSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 313
            ....|:|.:.|.|....:|||||..|:|:..:...|::|||.::|...|:|..:..||..:||||
Yeast   137 LFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPE 201

Human   314 VIRNEPVSE-KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLR 377
            :|....... |:||||.||:|:.|:||.:|:.|.|.:...|.:.:....... ...||..:.|:.
Yeast   202 LIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDA-KVIPDDARDLIS 265

Human   378 QCWNSKPRNRPSFRQILLH--LDIASADVLSTPQE---------TYFKSQAEWREEVKLHFEKIK 431
            :.....|..|||..|:|.|  |....:.||...|:         |.|||:.|.|     ..:::|
Yeast   266 RLLAKNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSKLERR-----LLKRLK 325

Human   432 SEGTCLHRLEEELVMRRREEL-----------------------RHALDIREHYERKLERANNLY 473
            ..|.....:::.::.::.:.|                       |..|.:::..|.......|..
Yeast   326 QSGVDTQAIKQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKVIESATHNDTNGI 390

Human   474 MELNALMLQLELK-----ERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKL- 532
            .| :.|...|||.     .:.|.:....:....|...|.......:...|:.|:..:|.....:
Yeast   391 SE-DVLKPSLELSRAASLSKMLNKGSDFVTSMTPVSRKKSKDSAKVLNPTLSKISSQRAYSHSIA 454

Human   533 -SPHSKRPDILKTESLLPKLDAALS----------GVGLPGCPKGPPSPG---RSRRGKTRHRKA 583
             ||......:.|..|......::.|          ...|....:|.||.|   :...|..:..:.
Yeast   455 GSPRKSNNFLQKVSSFFKSKKSSNSNSNNSIHTNVSESLIASNRGAPSSGSFLKKNSGSIQKSRT 519

Human   584 ------SAKGSCGDL-PGLRTAVPPHEPGG--------PGSPGGLGGGPSAWEACPPALRGLH-- 631
                  |...|.|.| ..:..|:.|.....        .|:..||       :..|..|...|
Yeast   520 DTVANPSRTESIGSLNENVAGAIVPRSANNTTLENKKTSGNEIGL-------KVAPELLLNEHIR 577

Human   632 --HDLLLRKMSSSSPDLLSAALG---------SRGRGATGGAGDPGSPPPAR-----------GD 674
              ...|.|..||.|.::...:.|         ||.....|..    ||||.|           .|
Yeast   578 IEEPRLKRFKSSISSEISQTSTGNYDSESAENSRSISFDGKV----SPPPIRNRPLSEISQISND 638

Human   675 TPPSEGSAPGSTS----PDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAA 735
            |..||.|..|:.|    .|:           :.|    ..:..|.|.||...   |.|:.:|..
Yeast   639 TYISEYSTDGNNSSFKISDT-----------IKP----SYIRKGSETTSQYS---ASSEKMTNG- 684

Human   736 LLYRAAVTRSQ----KRGISSEEEEGEVDSEVELTSS-------QRWPQSLNMRQS-LSTFSSEN 788
              |.....|..    ....|:.|.....||..::|::       .|..::.|:::| |..|.::.
Yeast   685 --YGRKFVRRDLSIVSTASSTSERSSRTDSFYDITTATPVVTTDNRRNKNNNLKESVLPRFGTQR 747

Human   789 PSDGEE--------GTASEPSPSGTPEVGSTNTD-------ERPDERSDDMCSQGSEIPLDPPPS 838
            |..|:.        ..|...|..|..::.|:|||       ...:|..:.:.|:|..:|
Yeast   748 PWTGKRTYTTSRHGKNARRSSKRGLFKITSSNTDSIIQEVSSSEEEDHNVIYSKGKGLP------ 806

Human   839 EVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPAS 889
                      .|:...:.|.|.| .|..|.:.|.....:::...:::|..|
Yeast   807 ----------TPVLQTKGLIENG-LNERDEEGDDEYAIHTDGEFSIKPQFS 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	71/251 (28%)
MAP3K12	NP_001180440.1	TyrKc	165..397	CDD:197581	70/247 (28%)
YPL150W	NP_015175.1	STKc_AMPK-like	40..286	CDD:270905	72/256 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910