DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K12 and RAD53

DIOPT Version :9

Sequence 1:	NP_001180440.1	Gene:	MAP3K12 / 7786	HGNCID:	6851	Length:	892	Species:	Homo sapiens
Sequence 2:	NP_015172.1	Gene:	RAD53 / 855950	SGDID:	S000006074	Length:	821	Species:	Saccharomyces cerevisiae

Alignment Length:	443	Identity:	114/443 - (25%)
Similarity:	182/443 - (41%)	Gaps:	102/443 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   158 ILDLQWVGSGAQGAV--FLGRFHGEEVAVKKVRDLK--------ETDIKHLRKLKHPNIITFKGV 212
            |:| :.||.||...|  .:.|..|:..|||.:...|        ..:::.|:||.||.|:..||.
Yeast   199 IID-EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262

Human   213 CTQAPCYCILMEFCAQGQLYEVLR--------AGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD 269
            ......|.::|||.:.|.|.:.:.        |||.::..:|.        .:.|:|...|.|||
Yeast   263 YEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILT--------AIKYIHSMGISHRD 319

Human   270 LKSPNMLITYDD--VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV------------ 320
            ||..|:||..||  :|||:|||.:|...:.|...:|.||:|::||||||.:..
Yeast   320 LKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNE 384

Human   321 -SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLH------LPVPSSCPDGFKILLRQ 378
             |..||:||.|.:::.:|||.:|:.......:...:|..|.|      ..:.....|....||:
Yeast   385 YSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQ- 448

Human   379 CWNSKPRNRPSFRQILLHLDIASADV----------LSTPQETYFKSQAEWREEVKLHFEKIKSE 433
               ..|.||.:..:.|.|..|..:.:          :|..|....:...|..::.:..|.|.:
Yeast   449 ---VDPNNRSTAAKALNHPWIKMSPLGSQSYGDFSQISLSQSLSQQKLLENMDDAQYEFVKAQ-- 508

Human   434 GTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALE 498
                .:|:.|..::.:::        |..:.|::   ...:..:|.:...:.|..|...|||.
Yeast   509 ----RKLQMEQQLQEQDQ--------EDQDGKIQ---GFKIPAHAPIRYTQPKSIEAETREQK-- 556

Human   499 RRCPGLLKPHPSRGLLHGNTME--KLIKKRNVPQ--KLSPHSKRPDILKTESL 547
                          |||.|..|  |..||:...:  .|.|   .||.:..|||
Yeast   557 --------------LLHSNNTENVKSSKKKGNGRFLTLKP---LPDSIIQESL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	81/274 (30%)
MAP3K12	NP_001180440.1	TyrKc	165..397	CDD:197581	79/270 (29%)
RAD53	NP_015172.1	FHA	63..134	CDD:238017
		STKc_Rad53_Cds1	196..465	CDD:271000	83/278 (30%)
		FHA	578..684	CDD:238017	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910