DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K12 and KIN4

DIOPT Version :9

Sequence 1:	NP_001180440.1	Gene:	MAP3K12 / 7786	HGNCID:	6851	Length:	892	Species:	Homo sapiens
Sequence 2:	NP_014876.1	Gene:	KIN4 / 854408	SGDID:	S000005759	Length:	800	Species:	Saccharomyces cerevisiae

Alignment Length:	894	Identity:	184/894 - (20%)
Similarity:	294/894 - (32%)	Gaps:	288/894 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   117 GSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEE 181
            ||...||.||.::..||   ||.|:.         |||                         ::
Yeast    49 GSTLGEGEFGKVKLGWT---KASSSN---------EVP-------------------------KQ 76

Human   182 VAVKKVRDLKET-------------DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYE 233
            ||:|.:|  ::|             :|..|:.|.|||||..:.|...:....|::||.:.|:.|:
Yeast    77 VAIKLIR--RDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYK 139

Human   234 VLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKE-LSDK 297
            .::..|.:..|........:..|:||:|...::|||||..|:|:...:.:.|:|||...| ..|.
Yeast   140 YIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDN 204

Human   298 STKMSFAGTVAWMAPEVIRNEPVSE--KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 360
            ....:..|:..:.|||::.:....|  |.|:||.||:|:.:|.|.:|:.|...:.    .|.:..
Yeast   205 ELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENP----TGDDIA 265

Human   361 HL----------------PVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQ 409
            .|                |:|       :.|||:.....||.|.:.:.|..|       |...|.
Yeast   266 RLYKYITQTPLKFPEYITPIP-------RDLLRRILVPNPRRRINLQTIKRH-------VWLKPH 316

Human   410 ETYFKSQAE-WREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREH---------YER 464
            |.:...|.. |.|.::....|..::|                      |:..|         |.:
Yeast   317 EAFLSIQPNYWDEHLQKERPKPPNKG----------------------DVGRHSTYSSSASSYSK 359

Human   465 KLERANNLY----MELNALMLQL-----------------------ELKEREL------------ 490
            ..:| |:|.    :|.:.:..||                       ::||..:
Yeast   360 SRDR-NSLIIESTLEQHRMSPQLATSRPASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYT 423

Human   491 --------LRREQALERRCPGLLKPHPSRGLLHGNTMEKLI---------KKRNVP-QKLSPHSK 537
                    .:.||...|        |.|||..| .::..|:         :.||.| .||:.|
Yeast   424 RDSKGNGQTQIEQVSAR--------HSSRGNKH-TSVAGLVTIPGSPTTARTRNAPSSKLTEH-- 477

Human   538 RPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVPPH 602
                :|..|...........:|....|:..|.|.....|.:|:   :|..|..|:|
Yeast   478 ----VKDSSQTSFTQEEFHRIGNYHVPRSRPRPTSYYPGLSRN---TADNSLADIP--------- 526

Human   603 EPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGS 667
                   ...||......:|..|......||.....:|::|..|||             .|....
Yeast   527 -------VNKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLS-------------EGPAAK 571

Human   668 PPPA----------RGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSGRG 722
            ..|.          .||.|.:|.....:..........|.|...:.| |....:...:|.|:...
Yeast   572 TSPVDYHYAIGDLNHGDKPITEVIDKINKDLTHKAAENGFPRESIDP-ESTSTILVTKEPTNSTD 635

Human   723 GSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSE 787
            .....||         ...|..|..:..:|.:::.:...|.:..|......|||  .|.||..|.
Yeast   636 EDHVESQ---------LENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSLN--GSRSTVESR 689

Human   788 NPSDGEEGTASEPSPSGTPEVGSTN-TDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPI 851
            . |.|.....|..:|||.....:.. |.::|...||.                 :|.|:...
Yeast   690 T-SKGNAPPVSSRNPSGQSNRSNIKITQQQPRNLSDR-----------------VPNPDKKI--- 733

Human   852 PHQELLRERGPPNSEDS----------------DCDSTELDN-SNSVDA 883
             :...:|:..|..:|..                :.:.:||.| .|:|:|
Yeast   734 -NDNRIRDNAPSYAESENPGRSVRASVMVSTLREENRSELSNEGNNVEA 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	66/267 (25%)
MAP3K12	NP_001180440.1	TyrKc	165..397	CDD:197581	65/263 (25%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	81/320 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910