Protein Alignment MAP3K12 and ark1

DIOPT Version :9

• Sequence 1: NP_001180440.1
• Gene: MAP3K12 / 7786
• HGNCID: 6851
• Length: 892
• Species: Homo sapiens
• Sequence 2: NP_001018849.1
• Gene: ark1 / 3361036
• PomBaseID: SPCC320.13c
• Length: 355
• Species: Schizosaccharomyces pombe
• Alignment Length: 334
• Identity: 82/334 - (24%)
• Similarity: 142/334 - (42%)
• Gaps: 68/334 - (20%)

Human    76 FANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYS 140
            |.:|:.::.|..||.|..|  .|:.|...:                 |:|        .|||.
pombe    59 FNSSLRKIEEPIAGVPSSA--GPQWREFHI-----------------GMF--------EIGKP-- 94

Human   141 TEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGR------------FHGEEVAVKKVRDLKET 193
                                   :|.|..|.|:|.:            .|..|:...|:......
pombe    95 -----------------------LGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRR 136

Human   194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 258
            :|:....|:|.||:...|.........:::||..:|:||:.||..:..:..:...:...:|..::
pombe   137 EIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALS 201

Human   259 YLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323
            |||...:||||:|..|:|:..|..:|:||||.|.. :..:.:.:..||:.::.||::..:..:||
pombe   202 YLHKKHVIHRDIKPENILLGIDGEIKLSDFGWSVH-APSNRRTTLCGTLDYLPPEMVEGKEHTEK 265

Human   324 VDIWSFGVVLWELLTGEIPYKDVDS-SAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNR 387
            ||:||.||:.:|.|.|..|::|:.. ||....:.  .:.|.:||..|...:.|:.:.....|..|
pombe   266 VDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIA--KVDLKIPSFVPPDARDLISRLLQHNPEKR 328

Human   388 PSFRQILLH 396
            .|..|::.|
pombe   329 MSLEQVMRH 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K12	NP_001180440.1	STKc_MAP3K12_13	164..400	CDD:270961	68/246 (28%)
		TyrKc	165..397	CDD:197581	68/245 (28%)
ark1	NP_001018849.1	STKc_Aurora	89..341	CDD:270909	72/285 (25%)
		S_TKc	89..340	CDD:214567	72/285 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910