DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZP2 and zpax2

DIOPT Version :9

Sequence 1:	NP_001363162.1	Gene:	ZP2 / 7783	HGNCID:	13188	Length:	756	Species:	Homo sapiens
Sequence 2:	NP_001038334.3	Gene:	zpax2 / 558615	ZFINID:	ZDB-GENE-040724-123	Length:	890	Species:	Danio rerio

Alignment Length:	717	Identity:	175/717 - (24%)
Similarity:	278/717 - (38%)	Gaps:	192/717 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    11 SPSGWFNAGWSTYRSISLFFALVTSGNSIDVSQLVNPAF-----PGTVTCDEREITVEFPSSPGT 70
            :|.|:|.:.              |..:...:|..:.|..     .|.   |:.:.||.||.:...
Zfish   313 APDGYFKSH--------------TLKDQYHISYTIEPMLELLWREGV---DKTKYTVLFPMTTPL 360

Human    71 KKWHASVVDP-----------LGLDMPNCTYILDPEKLTLRATYDNCTRRVHGGHQMTIRVMNNS 124
            ..|...:.|.           ||..:|      |.|.|::..          |...:|:..:
Zfish   361 TPWPPQIADKTEPDQKMFDVFLGYFLP------DVELLSVTI----------GSELITVPEL--- 406

Human   125 AALRHGAVMYQFFCPAMQVEETQGLSASTICQKDFMSFSLPRVFSGLADDSKGTKVQMGWSIEVG 189
              :..|.|:.:...|    .:|:..|..       :.||.|.|        :..||.:.
Zfish   407 --IFKGIVLQEHSFP----NDTKAFSLQ-------IPFSEPHV--------QIKKVHLD------ 444

Human   190 DGARAKTLTLPEAMKEGFSLLIDNHRMTFHVPFNATGVTHYV----QGNSHLYMVSLKLTF---- 246
                ..|.|||...  ||::|.| |....|.....|.||..|    :|:.|.....:.:.|
Zfish   445 ----KTTYTLPVVF--GFTVLPD-HSSFSHSAELETSVTDTVLPKAEGSCHQDHFDMHVAFGSVP 502

Human   247 -----ISPGQKVIFSSQAICAPDPVTCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDL 306
                 |..||..:  :..|........|.||:|:.:|          |.:..:.:..:...||
Zfish   503 SSELKIKLGQTEL--NDEILQQFEHHLNKTHLTIVVP----------FLSPVVALESVQLTGI-- 553

Human   307 EATNGMKLHFSKTLLKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGEL 371
            |....:|::.|....|           |...||..|||::        ..||.....|::|..:|
Zfish   554 EGRIDVKMYNSMNNWK-----------FNDVSLTCTFLVK--------LSECFPNGTVTVVLPKL 599

Human   372 CTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVV 436
                       .|.|..|    |.|.:.:.:|:|.:........|:::  ..|||..||.:|.::
Zfish   600 -----------ESVQYLP----GELSLRDPTCKPYYNEDHFAYFRYNV--TSCGTTRKFVEDTMI 647

Human   437 YENEIHALWTDFP-PSKISRDSEFRMTVKCSYSRN--DMLLNINVESLTPPVASVKLGPFTLILQ 498
            |||||.:.....| .|::..:.|:|..|.|.|..|  :.::...|.....|.|.|..|..::.|:
Zfish   648 YENEITSKTDPLPQTSELEPEPEYRFIVSCVYVANATESMIFHAVSHFKEPHADVGKGELSVSLK 712

Human   499 SYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVV 563
            ...|..|:..|.|.:|||::||:||:|.||.:.:..|..:.:.|::||||.|.|.:|.|:|:::|
Zfish   713 LSQDMVYKLFYHEGDYPLLKFLKQPLYFEVGMDHSRDSKMAVGLENCWATLTKDKESKPRWDLIV 777

Human   564 DGCAYDLDNYQTTFHPV--GSSVTHPDHYQRFDMKAFAF-------VSEAHVLSSLVYFHCSALI 619
            |||....:  ||...||  ...:..|||::||::|...|       .::|......|:.||..||
Zfish   778 DGCPKGPE--QTKIRPVIADDRIDIPDHFKRFEVKMLDFTEKDRSSTNDAANTMRRVFIHCDVLI 840

Human   620 CNR------------LSPDSPLCSVTCPVSSRHRREAKHKLDHLSPATGATEAEKMTVSLPGPIL 672
            |:.            :||.:|..|     |||.||.::           .:|.:...||| ||||
Zfish   841 CHTENTADGRCYKQCMSPLNPQIS-----SSRVRRSSR-----------LSEEDLRHVSL-GPIL 888

Human   673 LL 674
            |:
Zfish   889 LI 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZP2	NP_001363162.1	Zona_pellucida	372..631	CDD:365872	83/282 (29%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:P20239	469..491		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..719
zpax2	NP_001038334.3	Zona_pellucida	586..855	CDD:306582	84/287 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28MMD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5847
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810