DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZP2 and si:zfos-1505d6.3

DIOPT Version :9

Sequence 1:	NP_001363162.1	Gene:	ZP2 / 7783	HGNCID:	13188	Length:	756	Species:	Homo sapiens
Sequence 2:	XP_002665864.2	Gene:	si:zfos-1505d6.3 / 100333772	ZFINID:	ZDB-GENE-120214-22	Length:	432	Species:	Danio rerio

Alignment Length:	346	Identity:	110/346 - (31%)
Similarity:	168/346 - (48%)	Gaps:	61/346 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   357 ECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRV--GNS-SCQPVFEAQSQGLVRFH 418
            :|...:.|::    .|.:||...|.|....|.|.|.|.|:.:  ||. .|.||  |.:.....:.
Zfish   114 QCYYGNAVTV----QCIRDGQFVVVVARDVTVPRLSLDTVSLLGGNDPPCSPV--ASNPYFAVYQ 172

Human   419 IPLNGCGTRYKFEDDKVVYENEIHALW--TDFPPSKISRDSEFRMTVKCSYSR---NDMLLNINV 478
            .|::.|||....|...|||||.:.:.:  ...|...|:|||:|.:..:|.||.   ..:::.:|.
Zfish   173 FPVSACGTNVIEERGHVVYENRMVSSYEVAMGPLGSITRDSQFEVLFQCRYSNTAVEALVVEVNA 237

Human   479 ESLTPPVASVKLGPFTLILQ-----------SYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLN 532
            ....||||:  |||..:.|:           :..|.:|...|.|.:||:.:.||:|:|::|.:|.
Zfish   238 IRAPPPVAA--LGPLRVELRLANGQCVTKGCAEGDEAYTSYYNEADYPVTKVLREPVYVDVHILE 300

Human   533 RDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPV--GSSVTHPDHYQRFDM 595
            |.||||.|:|.:||||||.||.|.|:|:::|:||....|.|.||..||  .|.|..|:|::||.:
Zfish   301 RTDPNIVLMLGNCWATSTPDPLSVPRWDLLVNGCPNQDDRYLTTLVPVTASSGVHFPNHHKRFIV 365

Human   596 KAFAFVSEAHV--LSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRREAKHKLDHLSPATGAT 658
            |.|.||....:  :...|:.||:..:|...:..|  |..:|   :|.||:.
Zfish   366 KMFTFVDPQSLSPVQQTVFIHCNTAVCYPSATQS--CEQSC---ARKRRDI-------------- 411

Human   659 EAEKMTVSLPGPILLLSDDSS 679
                       |.|.:|||::
Zfish   412 -----------PDLQISDDTA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZP2	NP_001363162.1	Zona_pellucida	372..631	CDD:365872	98/281 (35%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:P20239	469..491		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..719
si:zfos-1505d6.3	XP_002665864.2	PD	81..121	CDD:197472	1/6 (17%)
		ZP	143..407	CDD:214579	93/272 (34%)
		Zona_pellucida	270..404	CDD:278526	55/135 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28MMD
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266424at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820