Protein Alignment SLC30A4 and ZnT77C

DIOPT Version :10

• Sequence 1: NP_037441.2
• Gene: SLC30A4 / 7782
• HGNCID: 11015
• Length: 429
• Species: Homo sapiens
• Sequence 2: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 71/354 - (20%)
• Similarity: 153/354 - (43%)
• Gaps: 82/354 - (23%)

Human   102 REILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSK 166
            ::||::.|.....|: .||.:.:.:.:|:..::.:.|.::..:.|||.::.|:...::.:..|.:
  Fly     3 KDILQRCKPIPLYTV-LVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQ 66

Human   167 SP---------TK----------------------------RFTFGFHRLEVLSAMISVLLVYIL 194
            :|         ||                            |.|||:.|:::|:.:|..:::..|
  Fly    67 APEARNPSPALTKINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASL 131

Human   195 MGFLLYEAVQRTIHMNYEINGDIM------LITAAVGVAVN-----VIMGFLLNQSGHRH----- 243
            ...|:.||:|..:|::::   |.|      ::...:|:.:|     :|.|:.|:|....|
  Fly   132 SFSLVVEALQTLVHIDHQ---DTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGG 193

Human   244 --------SHSHSLPSNSPTRGSGCERNHGQ--DSLAV----------RAAFVHALGDLVQSVGV 288
                    |.:..|......|.....||..|  :.|..          |...|..|.|:..::.|
  Fly   194 NVVLERPMSSNLDLSLTPMQRHLSKSRNDRQLREELETEVGSVYFATKRQGAVEMLRDVSSTIFV 258

Human   289 LIAAYIIRFKPE----YKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALM 349
            ::.|.|:....:    .|..||:.:....:|:...::..:.::.:|:|:.:|..::::..:..|:
  Fly   259 IVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTLV 323

Human   350 -KIEDVYSVEDLNIWSLTSGKSTAIVHIQ 377
             |..::.|..||:||.|.:.:..|.:|||
  Fly   324 TKFPEIISYHDLHIWQLAAHRYVATIHIQ 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC30A4	NP_037441.2	CDF	123..413	CDD:273544	65/333 (20%)
		Zinc binding. /evidence=ECO:0000250|UniProtKB:O55174	240..264		5/36 (14%)
ZnT77C	NP_649233.2	CzcD	14..383	CDD:440843	68/343 (20%)