Protein Alignment SLC30A1 and ZnT77C

DIOPT Version :10

• Sequence 1: NP_067017.2
• Gene: SLC30A1 / 7779
• HGNCID: 11012
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 142/540 - (26%)
• Similarity: 224/540 - (41%)
• Gaps: 149/540 - (27%)

Human    11 LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALV------------------- 56
            |..:|.|:..:.||::::|.:|..|.:|..|.|||.::.||...::
  Fly    14 LYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALT 78

Human    57 ---------------AERFARRTHATQK--NTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERF 104
                           |:..|:|....||  |||||.|.:::..|:..|.|..|.|::::||::..
  Fly    79 KINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTL 143

Human   105 IE-PHE--MQQPLVVLGVGVAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRVK 166
            :. .|:  |..|:.|:.:|..||::|.|...|.         .|:....|...|   |..|..|.
  Fly   144 VHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLI---------GGYTLHQGSFLH---LTPGGNVV 196

Human   167 STRPGSSDINVAPGEQGPDQEETNTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPD 231
            ..||.||:::                         |.|.|......:|.:  :.|:...|..|..
  Fly   197 LERPMSSNLD-------------------------LSLTPMQRHLSKSRN--DRQLREELETEVG 234

Human   232 HMELEEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFPDPCKAFVE 296
            .:.....|.|.:.|       |.|...::.|:|.|.:.|
  Fly   235 SVYFATKRQGAVEM-------LRDVSSTIFVIVCAAIVY-------------------------- 266

Human   297 IINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYT-TYPLLKESALILLQTVPKQIDI----RNL 356
                    |.|.......::||.|. :..|:||.| :||.:|||.||||||:|..||:    |.|
  Fly   267 --------VAEDEQHTAKFIDPVLS-IFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTL 322

Human   357 IKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPEF 421
            :.:...   :...|:||:||||..|.:||.||:.::|..|:::.:.::..||:.||.|.||||||
  Fly   323 VTKFPE---IISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRSYFHDQGIGAVTIQPEF 384

Human   422 ASVGSK--SSVVPCELACR-TQCALKQCC-------GTLPQAPSGKDA-----------EKTPAV 465
            ....:|  |:.:.|.:.|: .:|..|.||       ..:..||||:.:           |.:.|.
  Fly   385 YPSTNKNASASLECLMQCQAVECIEKVCCRDSRTDLREVCDAPSGRKSSSPVKCAGNSHEHSRAK 449

Human   466 SISCLELSNNLEKKPRRTKA 485
            |.||.|||..:.:||....|
  Fly   450 SKSCAELSAVVVEKPEELSA 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC30A1	NP_067017.2	CzcD	5..420	CDD:440843	116/452 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..217		14/74 (19%)
		6 X 2 AA approximate repeats of H-G	146..158		2/11 (18%)
ZnT77C	NP_649233.2	CzcD	14..383	CDD:440843	116/452 (26%)