Protein Alignment SLC30A1 and ZnT63C

DIOPT Version :10

• Sequence 1: NP_067017.2
• Gene: SLC30A1 / 7779
• HGNCID: 11012
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_001261364.1
• Gene: ZnT63C / 38407
• FlyBaseID: FBgn0035432
• Length: 545
• Species: Drosophila melanogaster
• Alignment Length: 480
• Identity: 185/480 - (38%)
• Similarity: 257/480 - (53%)
• Gaps: 116/480 - (24%)

Human     1 MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTH 65
            |..:...:.|||.|:.||..|..:|::|..||:|:|:::||||||.|:.|||::.::.:.:.:..
  Fly     1 MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKW 65

Human    66 ATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVGVAGLLVNVLG 130
            :  ||||||.||||:||||||:||..|||:|.:||.:||||...:.:|.:::.||..||||||:|
  Fly    66 S--KNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIG 128

Human   131 LCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRVKSTRPGSSDINVAPGEQGPDQ------EET 189
            |||.:.|.|.     |||||||     ||        ||..|....:|..::|.|:      |:.
  Fly   129 LCLLYEHGGH-----HGHSHGG-----GL--------TRNHSRLTELANMDEGEDEQNDFAYEKQ 175

Human   190 NTLVANTSNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHMELEEDRAGQLNMRGVFLHVLG 254
            ........:|:|...||                                  ||:||||.|||||.
  Fly   176 KEKAPVKKSSHGHSHDP----------------------------------GQMNMRGAFLHVLS 206

Human   255 DALGSVIVVVNALVFY-FSWKGCSEGDFCVNPCFPDPCKAFVEIINSTHASVYEAGPCWVLYLDP 318
            |||||:|||::|:|.: ..||                                     :..|:||
  Fly   207 DALGSIIVVISAVVVWKTEWK-------------------------------------YRYYMDP 234

Human   319 TLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKE-LRNVEGVEEVHELHVWQLAGSRI 382
            .|.:|:|.::|::.:|||:|||||||||||..|.:..:.|. |..|:||..|||.|||||||.||
  Fly   235 ALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRI 299

Human   383 IATAHIKCEDPTSYMEVAKTIKDVFHNHGIHATTIQPEFASV-------GSKSSVVP----CELA 436
            ||:|||:|.:.:.||::|:.:|:.|||.|||:|||||||:.:       |:.|..:.    |.|.
  Fly   300 IASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEIEGCNMSDGTSSINISGSDCCALD 364

Human   437 CRTQ---CALKQCC---GTLPQAPS 455
            |.|.   |....||   ..|.|.||
  Fly   365 CPTTEEGCVKATCCQNNNKLNQLPS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC30A1	NP_067017.2	CzcD	5..420	CDD:440843	168/422 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..217		20/80 (25%)
		6 X 2 AA approximate repeats of H-G	146..158		7/11 (64%)
ZnT63C	NP_001261364.1	CzcD	10..340	CDD:440843	171/420 (41%)