DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF227 and CG15436

DIOPT Version :9

Sequence 1:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens
Sequence 2:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster

Alignment Length:	364	Identity:	105/364 - (28%)
Similarity:	153/364 - (42%)	Gaps:	77/364 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   277 CFSQSSHL------RTHQRIHPGEKLNRCH----ESGDCFN-----------KSSFHSYQSNHTG 320
            |...|..|      |...|:...|.:.:|.    :.||.|:           ||   :|....|.
  Fly     8 CMDISGKLVNIFDARRRTRVSIAEMIAQCTGFEVKRGDLFSEMICPQCYEDVKS---AYGIRQTC 69

Human   321 EKSYR--CDSCGKGFSSSTGLIIHY-----------------------RTHTGEKPYKCEECGKC 360
            |:|::  |....:|...:...::..                       ::.:.:..::|.||.|.
  Fly    70 EESHQFYCRVRDEGIEDALCALLEEEDWEISEDEDARIDSASAADDDGKSDSKKVAFECRECHKK 134

Human   361 FSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHI 425
            :.:...|..|.|.|.:.:.:.|..|.:.|...|.|:.|.:.|...|||:|..|.|.|.|.:....
  Fly   135 YQRKGTFLRHMRTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQS 199

Human   426 HQRVHTGEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHFRVHTGEK 490
            |:|.||||:|:||..|.|.|..:|.|..|.|.|..|:|:||..|.|.|||...|..|||.||||:
  Fly   200 HERTHTGERPFKCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGER 264

Human   491 PYKCKECGKGFSQASNLQVHQNVHTGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGK 555
            |                            |||..|.|.|:....|:.|.|:|..::|:||..|.|
  Fly   265 P----------------------------FKCSHCPKAFAMKQHLKQHSRLHLPDRPFRCSHCPK 301

Human   556 DFSYSSNLKLHQVIHTGEKPYKCEECGKGFSWRSNLHAH 594
            .|..||.||.|:::|..|:.:||..|...:..|..|..|
  Fly   302 TFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARH 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	2/42 (5%)
		zf-H2C2_2	342..363	CDD:316026	4/43 (9%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		COG5048	406..779	CDD:227381	72/189 (38%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		C2H2 Zn finger	466..486	CDD:275368	10/19 (53%)
		C2H2 Zn finger	494..514	CDD:275368	0/19 (0%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	9/19 (47%)
		C2H2 Zn finger	578..598	CDD:275368	5/17 (29%)
		C2H2 Zn finger	606..626	CDD:275368
		C2H2 Zn finger	634..654	CDD:275368
		C2H2 Zn finger	662..682	CDD:275368
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	16/72 (22%)
		C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		C2H2 Zn finger	156..176	CDD:275368	6/19 (32%)
		COG5048	<180..341	CDD:227381	72/189 (38%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		zf-H2C2_2	197..219	CDD:290200	11/21 (52%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	10/19 (53%)
		zf-H2C2_2	252..276	CDD:290200	14/51 (27%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910