DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF226 and CG5245

DIOPT Version :9

Sequence 1:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	188/450 - (41%)
Similarity:	266/450 - (59%)	Gaps:	9/450 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   334 PYKCKQCGKGFSRRSALNVHCKVHTAEKPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGK 398
            |.|.|.|....:::..|......      :.|.:|.:.|::..:|:.|.|||..|:||:|..|.|
  Fly    59 PSKLKTCKSKIAKKRPLRKQTDT------FKCTQCQKTFTRKENLESHLRLHAEERPFECSHCSK 117

Human   399 SFSRNSHLQSHQRVHTGEKPYKCEECGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQ 463
            ||.|.:|.:.|...|. ::|:||..|.|.|..:|:|..|...||||:|:||.:|...|:|.|.||
  Fly   118 SFGRRTHYKRHLLKHE-KRPHKCSHCSKTFTQNSSLKQHLHEHTGERPFKCTQCSTSFARKSHLQ 181

Human   464 AHQGVHTGEKSYICTVCGKGFTLSSNLQAHQRVHTGEKPYKCNECGKSFRRNSHYQVHLVVHTGE 528
            .|...|:.|:.:.||.|.|.|..:|:||.|.|.|...:|:||:.|.|||:..|..|.||:.| .|
  Fly   182 VHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHLLTH-AE 245

Human   529 KPYKCEICGKGFSQSSYLQIHQKAHSIEKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECG 593
            :.:||..|.|.|.|:..||||.:.|:.|.||||..|.:.|.::||||:|.|.|.|::|.||.:|.
  Fly   246 RSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPLKCSQCS 310

Human   594 KGFSRRADLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVHSGEKPFKCEECGKSFGRSAHL 658
            ..|:.|:..::|.|:||.|:.|.|.||.|.|.:.|:|:.||:||:||:||||..|.|.|....||
  Fly   311 ATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDFKCRTHL 375

Human   659 QAHQKVHTGDKPYKCDECGKGFKWSLNLDMHQRVHTGEKPYKCGECGKYFSQASSLQLHQSVHTG 723
            :.|...|.|:|..||..|.|.||.|..|.:|.:.|||:..::|..|.|.::.:|:|.:|...|||
  Fly   376 RVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMHLRTHTG 440

Human   724 EKPYKCDVCGKVFSRSSQLQSHQRVHTGEKPYKCEICGKSFSWRSNLTVH-HRIHVGDKS 782
            |.|:||..|.|:|:||::.|.|.|.|||||||||..|...::.:|:|..| .|...|.||
  Fly   441 ELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTKS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370
		SUF4-like	306..>357	CDD:411020	5/22 (23%)
		C2H2 Zn finger	309..334	CDD:411020	187/449 (42%)
		C2H2 Zn finger	309..329	CDD:275368
		C2H2 Zn finger	337..357	CDD:411020	3/19 (16%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		COG5048	359..774	CDD:227381	179/415 (43%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	10/19 (53%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	533..553	CDD:275368	9/19 (47%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		C2H2 Zn finger	617..637	CDD:275368	9/19 (47%)
		C2H2 Zn finger	645..665	CDD:275368	7/19 (37%)
		C2H2 Zn finger	673..693	CDD:275368	8/19 (42%)
		C2H2 Zn finger	701..721	CDD:275368	6/19 (32%)
		C2H2 Zn finger	729..749	CDD:275368	9/19 (47%)
		C2H2 Zn finger	757..777	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803		1/1 (100%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	176/411 (43%)
		C2H2 Zn finger	84..104	CDD:275368	6/19 (32%)
		C2H2 Zn finger	112..132	CDD:275368	8/19 (42%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	8/19 (42%)
		zf-H2C2_2	179..204	CDD:290200	10/24 (42%)
		C2H2 Zn finger	195..215	CDD:275368	10/19 (53%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	250..270	CDD:275368	9/19 (47%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128597
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5425
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840