DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF226 and CG11247

DIOPT Version :9

Sequence 1:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	120/334 - (35%)
Similarity:	177/334 - (52%)	Gaps:	23/334 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   296 PVHQKVHVGEKLKCDECGKEFSQGAHLQTHQKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHTA- 359
            ||.:|.||     |.:|.|||.....||.|..:|..|:|:|||.|||.:  |.|:|:...:.||
  Fly    87 PVKRKHHV-----CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSY--RQAVNLKNHITTAH 144

Human   360 --EKPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGKSFSRNSHLQSHQRVH--TGEKPYK 420
              .|.:.|.:|.::|:....|:.|.|||:||||:.||.|.|.|:|...||.|...|  |..:.:.
  Fly   145 EHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFN 209

Human   421 CEECGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQAH-QGVHTGEKSYICTVCGKGF 484
            |.:|...|..::||.:|...|.....::|..|...|:...:|:|| ...|.....:.|.:|.|..
  Fly   210 CTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMI 274

Human   485 TLSSNLQAHQRVHTGEKPYKCNECGKSFRRNSHYQVHLVVHTGEKPYKCEICGKGFSQSSYLQIH 549
            ....:|..|.:.||..|.:.|..|...|.:.|.|.||:.:||||:||:|.||.:.|:.||.|::|
  Fly   275 EPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLH 339

Human   550 QKAHSIEKPFKCEECGQ--GFNQSSRLQIH-QLIHTGEKPYKCEECGKGFSRRADLKIH------ 605
            .:.|:.||||:|:.|..  .|:|.:.|:.| :.||..:|||.||.|...|..:.:|:.|
  Fly   340 IRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAK 404

Human   606 CRIHTGEKP 614
            |.: .|:||
  Fly   405 CPV-DGDKP 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370	3/5 (60%)
		SUF4-like	306..>357	CDD:411020	20/50 (40%)
		C2H2 Zn finger	309..334	CDD:411020	10/24 (42%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:411020	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		COG5048	359..774	CDD:227381	94/271 (35%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..469	CDD:275368	6/20 (30%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		C2H2 Zn finger	561..581	CDD:275368	6/22 (27%)
		C2H2 Zn finger	589..609	CDD:275368	7/25 (28%)
		C2H2 Zn finger	617..637	CDD:275368
		C2H2 Zn finger	645..665	CDD:275368
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	701..721	CDD:275368
		C2H2 Zn finger	729..749	CDD:275368
		C2H2 Zn finger	757..777	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	60/165 (36%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/26 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/22 (41%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000