DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF214 and Meics

DIOPT Version :9

Sequence 1:	NP_001341759.1	Gene:	ZNF214 / 7761	HGNCID:	13006	Length:	617	Species:	Homo sapiens
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	127/339 - (37%)
Similarity:	194/339 - (57%)	Gaps:	12/339 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   260 CSICKACFSQRSDLYRHPRNH----IGKKLYGCDEVDGNFHQSSGVHFHQRVHIGEVPYSCNACG 320
            |:.|...:|.:..|.||...|    ..:|.:.||.....|..::.:..|:|.|.||.|:.|..|.
  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306

Human   321 KSFSQISSLHNHQRVHTEEKFYKI-ECDKDLSRNSLLHIHQRLHIGEKPFKCNQCGKSFNRSSVL 384
            |:::...:|.:|...|.|||.:|. :|||.......|..|.:.|.||:|:||..|.::|.::|.|
  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGL 371

Human   385 HVHQRVHTGEKPYKCDECGKGFSQSSNLRIHQLVHTGEKSYKCEDCGKGFTQRSNLQIHQRVHTG 449
            .:|.|:|..|:|:||:.|||||.|:.:|..|..||.|::.:||.||.|.|.::||:..|||.|:|
  Fly   372 KLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSG 436

Human   450 EKPYKCDDCGKDFSHSSDLRIHQRVHTGEKPYTCPECGKGFSKSSKL--HTHQRVHTGEKPYKCE 512
            .||:||::||:.|||:..|:.|.|:|||||||.|.:||||||.:..|  ||...|...::|:||.
  Fly   437 IKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCS 501

Human   513 ECGKGFSQRSHLLIHQRVHTG-EKP---YKCHDCGKGFSHSSNLHIHQRVHTGEKPYQCAKCGKG 573
            :|.|.:..:..|..|::.|.. ::|   ::|..|...|:....|..|...|. .:|:.|.:|.:|
  Fly   502 QCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEG 565

Human   574 FSHSSALRIHQRVH 587
            |....:|:.|.|:|
  Fly   566 FFSQKSLKKHLRLH 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF214	NP_001341759.1	KRAB	14..53	CDD:307490
		COG5048	246..587	CDD:227381	126/337 (37%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..363	CDD:275368	5/17 (29%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		C2H2 Zn finger	427..447	CDD:275368	10/19 (53%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		C2H2 Zn finger	483..503	CDD:275368	10/21 (48%)
		C2H2 Zn finger	511..531	CDD:275368	5/19 (26%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..614	CDD:275368
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	73/186 (39%)
		zf-C2H2	412..434	CDD:278523	11/21 (52%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..451	CDD:290200	13/24 (54%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	8/15 (53%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000