DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA1D and NaCP60E

DIOPT Version :9

Sequence 1:XP_011532396.1 Gene:CACNA1D / 776 HGNCID:1391 Length:2246 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:3053 Identity:585/3053 - (19%)
Similarity:981/3053 - (32%) Gaps:1282/3053 - (41%)


- Green bases have known domain annotations that are detailed below.


Human   117 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALA 181
            :|:|.|:.|. .:..|..|       ||.....:|.||.|:.|...:.||..::..|..||:.||
  Fly    88 VSKRFRKNYI-HRFTGTKS-------LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA 144

Human   182 IYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL 246
            :            ...:|:.||.||.|:::|..:||||.|.||:...|:||.||.||||::..|.
  Fly   145 M------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGY 197

Human   247 FSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 311
            .::.:|.       ||          :..||.|||||.|:.||.:|.|:.::|:::.:...|..:
  Fly   198 ATIGMEV-------GN----------LAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245

Human   312 ALLVLFVIIIYAIIGLELFIGKMHKTC------------------FFADSD-IVAEEDPAP--CA 355
            ..|.:|.::::|:..|::::|::...|                  :..|:| .:.:||..|  |.
  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCG 310

Human   356 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPW 420
            .....|.|..... |......||.|.||||||.::|||.||.||::.|.:| |.|..|....:..
  Fly   311 NLTGARHCPFEYV-CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSV 373

Human   421 VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAED- 484
            .:|..:|.||||:::||:|.|::..:.:|.|..           .::.::||..:.|..|.:.| 
  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT-----------NEERKKDLLDHRDDSTFSFDP 427

Human   485 -------IDPENEE-----------------------EGGEEGKRN------------------- 500
                   ::..|::                       :||:||..|                   
  Fly   428 SVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPS 492

Human   501 ---------TSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRR-------- 548
                     |..|::.|.....:....|.:::              .||:|..|...        
  Fly   493 PGPSPRHSATERPSALTMQAQKQYQQMEQQHK--------------LAKSGSGGSNNPMAPTPKG 543

Human   549 ----------------------WGQAISKS----------------------------------- 556
                                  .||.|:.|                                   
  Fly   544 RISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMG 608

Human   557 -------KLSRRWRRWNRFN-----------------------------RRRCRAAVKSVTFY-- 583
                   .||.|..|..:.|                             .|.|...|...|.|  
  Fly   609 HVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYES 673

Human   584 WL------------------VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 630
            ||                  :.:.:.|||..::.||:...:......|:.|||..::||.|.:||
  Fly   674 WLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVK 738

Human   631 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSN 695
            :.:|. :.:|:..:|.||..:|...:.:.|   .|::.  |:||.|.:||||:.|:.:.||::..
  Fly   739 LMALS-KDFFLCGWNIFDLLIVTASLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKV 797

Human   696 LVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDETQTKRSTFDNFPQALLTVFQ 757
            |::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||.....|..|::|..:.:.:|:
  Fly   798 LLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFR 862

Human   758 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNTA 821
            ||.|| |...::|.:.|   ....|...|. .|:...:.||:::||:|||:.: |..::|.|.:.
  Fly   863 ILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSK 922

Human   822 QKEEAEEKE-------------RKKIARKESLENK-----------------------------K 844
            ::|..||.:             :|:..||:..|.|                             :
  Fly   923 KEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLER 987

Human   845 NNKPEV-------------------------NQIANSDNKVTIDDYREEDEDKD----------P 874
            .:||.|                         .||...|...||.|..|.|:..|          |
  Fly   988 GDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHP 1052

Human   875 YPPC--DVP-------------------------------------------------------- 881
            .||.  .:|                                                        
  Fly  1053 LPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEA 1117

Human   882 --------------------------------------------VGEEE---------------- 886
                                                        .|.||                
  Fly  1118 TYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRS 1182

Human   887 ----------------------------------------------------------------- 886
                                                                             
  Fly  1183 PSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQK 1247

Human   887 ------EEEEE------------------------------------------------------ 891
                  :||||                                                      
  Fly  1248 ELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRS 1312

Human   892 -----------------------------------------DEPEVPAGP--------------- 900
                                                     ||..:|..|               
  Fly  1313 TTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQS 1377

Human   901 ------------------RPRRISE---------------------------------------- 907
                              :.|:|.|                                        
  Fly  1378 VSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQS 1442

Human   908 -------------------LNMKEKIAPIPEGS-------------------------------- 921
                               |::.|::..:||..                                
  Fly  1443 PFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLK 1507

Human   922 ---------------------------------------------------------------AF 923
                                                                           |.
  Fly  1508 STNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHAT 1572

Human   924 FILSKTNPIRVGCHKLINHH--------------------------------------------- 943
            .|.:...|.....|...:.|                                             
  Fly  1573 SIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAM 1637

Human   944 -------------------IFTNL----------------------------------------- 948
                               .||.|                                         
  Fly  1638 AQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKA 1702

Human   949 ------------------------------------------------------ILVFIMLSSAA 959
                                                                  :||.|..||..
  Fly  1703 AKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSIT 1767

Human   960 LAAED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS 1023
            |..|| .:..:.....:|.:.:::|..||.||::||....|.    ..:..:::.:||.::|.||
  Fly  1768 LCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVS 1828

Human  1024 LVSFGIQSSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1087
            :.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:
  Fly  1829 VFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFS 1893

Human  1088 CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALF 1152
            .:|||.|.|||::|.:|...       |..:.:..|....:.:...|.||...||:|....:||.
  Fly  1894 IMGVQFFGGKFFKCVNEMGE-------LLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALL 1951

Human  1153 TVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ---- 1213
            .|:|||||..::..|:|:.|.::.|.....:...|:|:|:|:..:||.:|:|:|.:|..|.    
  Fly  1952 QVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKK 2016

Human  1214 --EQGEKEYKNCELDKNQRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIM 1273
              |.|..|....|..|:....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.
  Fly  2017 KYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIF 2079

Human  1274 LNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSI 1338
            ||.|.:.::||:|.......:::.|..||.||.:|.::|::..:   |                 
  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR---Y----------------- 2124

Human  1339 IDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPV-PTATPGNSEESNRISITF 1402
                     ||||..||.||.|:|:.|:..|.:.::    ..::|: ||.            :..
  Fly  2125 ---------HYFTVPWNVFDFLLVLASIFGILMEDI----MIDLPISPTL------------LRV 2164

Human  1403 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQ 1467
            .|:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.||||::||.:||.|.::  ..
  Fly  2165 VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ--GA 2227

Human  1468 INRNNNFQTFPQAVLLLFRCATGEAWQEIM--LACLPGKLCDP----ESDYNPGEEYTCGSN-FA 1525
            ::...|||||.:::.||||..|...|.:::  |...|.. |||    .::.|      ||.. .|
  Fly  2228 LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD-CDPFIHGHTNGN------CGHPLLA 2285

Human  1526 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLD 1589
            |.||.||.::...::||:::|:|::||:...::..| :....|:.|...||:|||.|...|....
  Fly  2286 ITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQ 2350

Human  1590 VVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL-KIKTEGNLEQ 1653
            :...:..:.||||..|  |:.||   ||:.|:|::....:.....|.|||:..| .::...|.:|
  Fly  2351 LSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQ 2410

Human  1654 ANEELRAVIKK---------------IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----D 1699
            ..|::....||               |||:...                     |...||    :
  Fly  2411 LQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKE 2454

Human  1700 YFRKFKKRKEQGLVGKYPAKNTTI-ALQAGLRTLHDIGPEI-RRAISC----------------D 1746
            |.|: |:.||:...|....:.::. ..|:.|..|:....:: ||..:|                |
  Fly  2455 YLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASD 2518

Human  1747 LQD----------------DEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRP 1795
            |.:                ||..:..:::.|::.|| |::.   |....:.||.|.......|:.
  Fly  2519 LSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR-GSIF---VEAPRASRRRSFYNFFLRHQD 2579

Human  1796 L---HVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRP 1857
            .   .:..||:                      |...::.....|::|:...:...|..|.....
  Fly  2580 AVDDSLTSPSV----------------------HRKTAMNNTTNTTSNSASTSGTASSTATAPAT 2622

Human  1858 SIG-NLEHVSENGHHSSHKHDREPQRR---SSVKRTRYYE--------------TYIRSDSGDEQ 1904
            ..| .....|::..|.:......|.|:   |.:::....|              .::...|..|.
  Fly  2623 GCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEV 2687

Human  1905 LPTICREDPE----IHGYFRDP------HCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGR 1959
            :.|  |..||    .|.....|      |.|..:|  |.|...||:|||:.|....|:     |.
  Fly  2688 IVT--RPSPEQQTHPHSLSLRPDNATLVHVLVHRE--SEEYKEEDESSPSVSGNGNGF-----GV 2743

Human  1960 NID--SERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEV 2022
            .:|  |::|    .||..:.........|:...|..:::..:|....|..|:             
  Fly  2744 GLDMLSKQP----PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFS------------- 2791

Human  2023 PSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWA-----------------TPP 2070
             |:||  .....|:.      :.|.|..|.....|:|..:|....                 .||
  Fly  2792 -SAPI--DDVGAPID------VNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPP 2847

Human  2071 ATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFR 2133
            ...|.||        .:...|......:.|..|:...|        |..:.:.||...||:.|
  Fly  2848 VNTPLRD--------SEKRSSRGSRSSSSSTSSIRSCS--------SSSSSSAASAAAPSARR 2894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1DXP_011532396.1 Ion_trans 180..454 CDD:278921 91/294 (31%)
Ion_trans 600..817 CDD:278921 66/220 (30%)
Ion_trans 960..1219 CDD:278921 83/266 (31%)
Ion_trans 1279..1560 CDD:278921 80/288 (28%)
GPHH 1568..1631 CDD:293510 20/62 (32%)
Ca_chan_IQ 1633..1704 CDD:285917 18/90 (20%)
CAC1F_C 1728..2243 CDD:293490 88/489 (18%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 76/237 (32%)
Ion_trans 705..902 CDD:278921 60/206 (29%)
Ion_trans 1768..2019 CDD:278921 81/261 (31%)
Na_channel_gate 2009..2063 CDD:240441 11/55 (20%)
Ion_trans 2085..2320 CDD:278921 80/288 (28%)
GPHH 2331..2386 CDD:293510 20/59 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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