Protein Alignment CACNA1D and NaCP60E

DIOPT Version :10

• Sequence 1: XP_011532396.1
• Gene: CACNA1D / 776
• HGNCID: 1391
• Length: 2246
• Species: Homo sapiens
• Sequence 2: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Alignment Length: 3053
• Identity: 585/3053 - (19%)
• Similarity: 981/3053 - (32%)
• Gaps: 1282/3053 - (41%)

Human   117 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALA 181
            :|:|.|:.|. .:..|..|       ||.....:|.||.|:.|...:.||..::..|..||:.||
  Fly    88 VSKRFRKNYI-HRFTGTKS-------LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA 144

Human   182 IYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL 246
            :            ...:|:.||.||.|:::|..:||||.|.||:...|:||.||.||||::..|.
  Fly   145 M------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGY 197

Human   247 FSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 311
            .::.:|.       ||          :..||.|||||.|:.||.:|.|:.::|:::.:...|..:
  Fly   198 ATIGMEV-------GN----------LAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245

Human   312 ALLVLFVIIIYAIIGLELFIGKMHKTC------------------FFADSD-IVAEEDPAP--CA 355
            ..|.:|.::::|:..|::::|::...|                  :..|:| .:.:||..|  |.
  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCG 310

Human   356 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPW 420
            .....|.|..... |......||.|.||||||.::|||.||.||::.|.:| |.|..|....:..
  Fly   311 NLTGARHCPFEYV-CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSV 373

Human   421 VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAED- 484
            .:|..:|.||||:::||:|.|::..:.:|.|..           .::.::||..:.|..|.:.|
  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT-----------NEERKKDLLDHRDDSTFSFDP 427

Human   485 -------IDPENEE-----------------------EGGEEGKRN------------------- 500
                   ::..|::                       :||:||..|
  Fly   428 SVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPS 492

Human   501 ---------TSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSGCRR-------- 548
                     |..|::.|.....:....|.:::              .||:|..|...
  Fly   493 PGPSPRHSATERPSALTMQAQKQYQQMEQQHK--------------LAKSGSGGSNNPMAPTPKG 543

Human   549 ----------------------WGQAISKS----------------------------------- 556
                                  .||.|:.|
  Fly   544 RISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMG 608

Human   557 -------KLSRRWRRWNRFN-----------------------------RRRCRAAVKSVTFY-- 583
                   .||.|..|..:.|                             .|.|...|...|.|
  Fly   609 HVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYES 673

Human   584 WL------------------VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVK 630
            ||                  :.:.:.|||..::.||:...:......|:.|||..::||.|.:||
  Fly   674 WLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVK 738

Human   631 MYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSN 695
            :.:|. :.:|:..:|.||..:|...:.:.|   .|::.  |:||.|.:||||:.|:.:.||::..
  Fly   739 LMALS-KDFFLCGWNIFDLLIVTASLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKV 797

Human   696 LVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDETQTKRSTFDNFPQALLTVFQ 757
            |::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||.....|..|::|..:.:.:|:
  Fly   798 LLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFR 862

Human   758 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNTA 821
            ||.|| |...::|.:.|   ....|...|. .|:...:.||:::||:|||:.: |..::|.|.:.
  Fly   863 ILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSK 922

Human   822 QKEEAEEKE-------------RKKIARKESLENK-----------------------------K 844
            ::|..||.:             :|:..||:..|.|                             :
  Fly   923 KEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLER 987

Human   845 NNKPEV-------------------------NQIANSDNKVTIDDYREEDEDKD----------P 874
            .:||.|                         .||...|...||.|..|.|:..|          |
  Fly   988 GDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHP 1052

Human   875 YPPC--DVP-------------------------------------------------------- 881
            .||.  .:|
  Fly  1053 LPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEA 1117

Human   882 --------------------------------------------VGEEE---------------- 886
                                                        .|.||
  Fly  1118 TYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRS 1182

Human   887 ----------------------------------------------------------------- 886
                                                                             
  Fly  1183 PSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQK 1247

Human   887 ------EEEEE------------------------------------------------------ 891
                  :||||
  Fly  1248 ELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRS 1312

Human   892 -----------------------------------------DEPEVPAGP--------------- 900
                                                     ||..:|..|
  Fly  1313 TTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQS 1377

Human   901 ------------------RPRRISE---------------------------------------- 907
                              :.|:|.|
  Fly  1378 VSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQS 1442

Human   908 -------------------LNMKEKIAPIPEGS-------------------------------- 921
                               |::.|::..:||..
  Fly  1443 PFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLK 1507

Human   922 ---------------------------------------------------------------AF 923
                                                                           |.
  Fly  1508 STNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHAT 1572

Human   924 FILSKTNPIRVGCHKLINHH--------------------------------------------- 943
            .|.:...|.....|...:.|
  Fly  1573 SIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAM 1637

Human   944 -------------------IFTNL----------------------------------------- 948
                               .||.|
  Fly  1638 AQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKA 1702

Human   949 ------------------------------------------------------ILVFIMLSSAA 959
                                                                  :||.|..||..
  Fly  1703 AKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSIT 1767

Human   960 LAAED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVS 1023
            |..|| .:..:.....:|.:.:::|..||.||::||....|.    ..:..:::.:||.::|.||
  Fly  1768 LCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVS 1828

Human  1024 LVSFGIQSSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1087
            :.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:
  Fly  1829 VFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFS 1893

Human  1088 CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALF 1152
            .:|||.|.|||::|.:|...       |..:.:..|....:.:...|.||...||:|....:||.
  Fly  1894 IMGVQFFGGKFFKCVNEMGE-------LLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALL 1951

Human  1153 TVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ---- 1213
            .|:|||||..::..|:|:.|.::.|.....:...|:|:|:|:..:||.:|:|:|.:|..|.
  Fly  1952 QVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKK 2016

Human  1214 --EQGEKEYKNCELDKNQRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIM 1273
              |.|..|....|..|:....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.
  Fly  2017 KYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIF 2079

Human  1274 LNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSI 1338
            ||.|.:.::||:|.......:::.|..||.||.:|.::|::..:   |
  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR---Y----------------- 2124

Human  1339 IDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPV-PTATPGNSEESNRISITF 1402
                     ||||..||.||.|:|:.|:..|.:.::    ..::|: ||.            :..
  Fly  2125 ---------HYFTVPWNVFDFLLVLASIFGILMEDI----MIDLPISPTL------------LRV 2164

Human  1403 FRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQ 1467
            .|:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.||||::||.:||.|.::  ..
  Fly  2165 VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ--GA 2227

Human  1468 INRNNNFQTFPQAVLLLFRCATGEAWQEIM--LACLPGKLCDP----ESDYNPGEEYTCGSN-FA 1525
            ::...|||||.:::.||||..|...|.:::  |...|.. |||    .::.|      ||.. .|
  Fly  2228 LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD-CDPFIHGHTNGN------CGHPLLA 2285

Human  1526 IVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLD 1589
            |.||.||.::...::||:::|:|::||:...::..| :....|:.|...||:|||.|...|....
  Fly  2286 ITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQ 2350

Human  1590 VVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL-KIKTEGNLEQ 1653
            :...:..:.||||..|  |:.||   ||:.|:|::....:.....|.|||:..| .::...|.:|
  Fly  2351 LSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQ 2410

Human  1654 ANEELRAVIKK---------------IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----D 1699
            ..|::....||               |||:...                     |...||    :
  Fly  2411 LQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKE 2454

Human  1700 YFRKFKKRKEQGLVGKYPAKNTTI-ALQAGLRTLHDIGPEI-RRAISC----------------D 1746
            |.|: |:.||:...|....:.::. ..|:.|..|:....:: ||..:|                |
  Fly  2455 YLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASD 2518

Human  1747 LQD----------------DEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRP 1795
            |.:                ||..:..:::.|::.|| |::.   |....:.||.|.......|:.
  Fly  2519 LSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR-GSIF---VEAPRASRRRSFYNFFLRHQD 2579

Human  1796 L---HVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRP 1857
            .   .:..||:                      |...::.....|::|:...:...|..|.....
  Fly  2580 AVDDSLTSPSV----------------------HRKTAMNNTTNTTSNSASTSGTASSTATAPAT 2622

Human  1858 SIG-NLEHVSENGHHSSHKHDREPQRR---SSVKRTRYYE--------------TYIRSDSGDEQ 1904
            ..| .....|::..|.:......|.|:   |.:::....|              .::...|..|.
  Fly  2623 GCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEV 2687

Human  1905 LPTICREDPE----IHGYFRDP------HCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGR 1959
            :.|  |..||    .|.....|      |.|..:|  |.|...||:|||:.|....|:     |.
  Fly  2688 IVT--RPSPEQQTHPHSLSLRPDNATLVHVLVHRE--SEEYKEEDESSPSVSGNGNGF-----GV 2743

Human  1960 NID--SERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEV 2022
            .:|  |::|    .||..:.........|:...|..:::..:|....|..|:
  Fly  2744 GLDMLSKQP----PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFS------------- 2791

Human  2023 PSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWA-----------------TPP 2070
             |:||  .....|:.      :.|.|..|.....|:|..:|....                  ||
  Fly  2792 -SAPI--DDVGAPID------VNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPP 2847

Human  2071 ATPPYRDWTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFR 2133
            ...|.||        .:...|......:.|..|:...|        |..:.:.||...||:.|
  Fly  2848 VNTPLRD--------SEKRSSRGSRSSSSSTSSIRSCS--------SSSSSSAASAAAPSARR 2894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1D	XP_011532396.1	Ion_trans	162..454	CDD:459842	96/312 (31%)
		Ion_trans	582..817	CDD:459842	72/258 (28%)
		Ion_trans	942..1219	CDD:459842	92/443 (21%)
		Ion_trans	1261..1560	CDD:459842	90/306 (29%)
		GPHH	1569..1622	CDD:465306	19/52 (37%)
		Ca_chan_IQ	1632..1706	CDD:462591	18/93 (19%)
		CAC1F_C	1727..2245	CDD:465298	88/490 (18%)
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	84/276 (30%)
		Ion_trans	687..902	CDD:459842	63/224 (28%)
		Ion_trans	1751..2019	CDD:459842	86/278 (31%)
		Na_channel_gate	2009..2063	CDD:240441	11/55 (20%)
		Ion_trans	2067..2320	CDD:459842	90/306 (29%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)