DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myh10 and zip

DIOPT Version :9

Sequence 1:	XP_006534552.1	Gene:	Myh10 / 77579	MGIID:	1930780	Length:	2007	Species:	Mus musculus
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	2038	Identity:	1236/2038 - (60%)
Similarity:	1570/2038 - (77%)	Gaps:	66/2038 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MAQRTGLEDPE-RYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAE 64
            |::.....||| :||.|:|....:|||||:||.|:|||:|.|..||.|||||.|.||||.|||||
  Fly    46 MSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE 110

Mouse    65 NGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYK 129
            .||:.|:.:|||||||||||.|||||||||||||||||||:|||||||||||||||||||:||||
  Fly   111 TGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYK 175

Mouse   130 NLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQY 194
            .||||:|.|:|.|:|.||||:|||::||::||||.||.||||||||||||||||||||||||||:
  Fly   176 KLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQF 240

Mouse   195 LAHVASSH---KGRKDH-----NIPQESPKPVK---------------------------PQGEL 224
            ||:||:|.   .|...|     |....:.|.:|                           .:|||
  Fly   241 LAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGEL 305

Mouse   225 ERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDER 289
            |:||||||||||:||||||||||||||||||||||||.:|:|.||||||||||||||:|||||||
  Fly   306 EQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDER 370

Mouse   290 TFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEIL 354
            |||||||||:||....:...:|:...:|.|||||.:|:||..|...||.|:::|:|||.:.|:..
  Fly   371 TFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN 435

Mouse   355 SMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQ 419
            |:.::||:||.||::.|::|||.|||::|:||||||:.||||::|.:.|||.||||||||||:|.
  Fly   436 SIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVT 500

Mouse   420 KAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQL 484
            |||||||.:|||||:|||.|||:|:|||:|||::||||||||||||||||:||||||||||||||
  Fly   501 KAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQL 565

Mouse   485 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEEC 549
            ||||||||||||||||||||||||||||||||.||||||||||.||||::|.   |::|||||||
  Fly   566 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEEC 627

Mouse   550 WFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVA 614
            |||||||||||:|||.....|.||.| ...:..|||.|:||||:|||.|.:||||||||||:|:.
  Fly   628 WFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIV 691

Mouse   615 TLLHQSSDRFVAELWKDEIQTIQRASFYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKG 679
            :||..|.|.||..:|||.                      .|||:.| ..:|:|.||:  :|:||
  Fly   692 SLLQGSQDPFVVNIWKDA----------------------EIVGMAQ-QALTDTQFGA--RTRKG 731

Mouse   680 MFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQ 744
            |||||..||||.|.|||.|||||||||||||||||||||||:|..||||||||||||||||||||
  Fly   732 MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQ 796

Mouse   745 GFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHL 809
            ||||||.|||||||||:||||.|||||||||:|||:||:|||||.||||:|||||||||||||||
  Fly   797 GFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHL 861

Mouse   810 EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKP 874
            |||||.||:|:|:.|||.|||:|||:.:.|:.|||:|::::|||||||||||:|||||::|||||
  Fly   862 EEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKP 926

Mouse   875 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 939
            ||:||:|||:|..|::||.:|:||...:....:|.|||:||.|.||..||||||||.||.|||||
  Fly   927 LLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEE 991

Mouse   940 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 1004
            .|:||.|:|||||:::.:||:|:||||||...|..||||::.:||||||||:|||.|||||||||
  Fly   992 SRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEK 1056

Mouse  1005 VTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1069
            |..:|||||.||::.|.:|||.|.:|||||:|:|..:.|..|||||||||:|||::.|.|..||:
  Fly  1057 VQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISE 1121

Mouse  1070 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDET 1134
            |||||.|:::.|||.:::|||::.|..||::|:.|.:.||||::.||.|:||||...|.|.|:|:
  Fly  1122 LEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEES 1186

Mouse  1135 LHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1199
            ..|..|.|..|||::|:||:|||.|:|||:|.||||.:|||||||||||.||.|:||||||||||
  Fly  1187 ATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQEL 1251

Mouse  1200 RTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1264
            |:|||||:|.|||:||:||.|||..:.|||.:|:..|..:::|||..::.|..|||.|..||.:|
  Fly  1252 RSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAEN 1316

Mouse  1265 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEE 1329
            .:||.|::.:...:.|::.:||:.::|:.||..|::|.:|.|.||.||..|||.|.:|::..|||
  Fly  1317 ADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEE 1381

Mouse  1330 AEKKGIKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1394
            ||.|.....|.|:.:||||.:.|:||:|||||||.|||::||:|.||.:||||.||::||::|.|
  Fly  1382 AELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYE 1446

Mouse  1395 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQE 1459
            :::..:.:|:.:.|||.::|....:.|||.||:|.||:|||.::::|.:...|:|:|:|.::|.|
  Fly  1447 RKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSE 1511

Mouse  1460 LDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALE 1524
            |:|.|::|:.||..|..||||||.||::|||||.||.:.|:|||.||.||||||||.||::|.|:
  Fly  1512 LEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELD 1576

Mouse  1525 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1589
            ||.:..|:.|.:.|.|:.:::||.:::....||||||||:|||||.|:.|::.|.|||||:||.|
  Fly  1577 EAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLT 1641

Mouse  1590 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKME 1654
            |||||||||||||:::||||||..::|..|||:|.|:||:|:||.||::|||||..|||||||:|
  Fly  1642 EDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLE 1706

Mouse  1655 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1719
            .|||::|..:|..||.:::.:|..:|||||:||..|:.|||:|:::|:.|.|||:|:|:|:||||
  Fly  1707 GDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAE 1771

Mouse  1720 ILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1784
            :|||.|:|||||||||.||.||||||:||||:|:..|.::|||||||||||.|||||||||||.|
  Fly  1772 VLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSE 1836

Mouse  1785 LLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1849
            :|.||.||..||::.|.||||.|:|.:||::|.|..||||||||||||.|:|.|.::|.||||:.
  Fly  1837 VLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIAT 1901

Mouse  1850 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1914
            |||||..||||||.|.|||....|..|:.:||:||:.|.:||||||.||:||||:|.|:|:|.||
  Fly  1902 LEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLK 1966

Mouse  1915 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSR-SGRRQLH 1978
            |.|:|.|||..:....:||.|||.:|..|:.|.::||:::||.:|||.|.|..|||| :|.....
  Fly  1967 RNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSK 2031

Mouse  1979 IEGASLELSDDDTESKTSDVNDT 2001
            ..|......|...:.::.|..|:
  Fly  2032 RAGGGGGGDDSSVQDESLDGEDS 2054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myh10	XP_006534552.1	Myosin_N	33..72	CDD:397036	26/38 (68%)
		MYSc_Myh10	99..802	CDD:276952	496/737 (67%)
		Myosin_tail_1	879..1959	CDD:396244	605/1079 (56%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	24/36 (67%)
		Myosin_head	133..854	CDD:278492	508/749 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	496/737 (67%)
		Myosin_tail_1	931..2011	CDD:279860	605/1079 (56%)
		Prefoldin	1431..1515	CDD:298833	34/83 (41%)
		FAM76	<1847..1926	CDD:292665	48/78 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1159	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55941
Inparanoid	1	1.050	2332	1.000	Inparanoid score	I35
Isobase	1	0.950	-	0	Normalized mean entropy	S1140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm44362
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.810