Protein Alignment CACNA1C and NaCP60E

DIOPT Version :9

• Sequence 1: XP_016875415.1
• Gene: CACNA1C / 775
• HGNCID: 1390
• Length: 2412
• Species: Homo sapiens
• Sequence 2: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Alignment Length: 3146
• Identity: 637/3146 - (20%)
• Similarity: 1024/3146 - (32%)
• Gaps: 1323/3146 - (42%)

Human   142 YGKPKKQGST----------------------TATRPPRALLCLTLKNPIRRACISIVEWKPFEI 184
            ||||.::..|                      |.|   ::|......:|.||.|:.|...:.|:.
  Fly    69 YGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGT---KSLFLFYPWSPARRVCVYIATNQFFDY 130

Human   185 IILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 249
            .::.||..||:.||:            ...:|..||:||.|:::|..:|:||.|.|.:...||||
  Fly   131 CVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183

Human   250 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 314
            .||.|||:::..|..:..:|.           |..||     ||.|||||.|:.||.:|.|:.::
  Fly   184 PWNWLDFVVITSGYATIGMEV-----------GNLAG-----LRTFRVLRALKTVSIMPGLKTII 232

Human   315 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPA-------------- 365
            |:::.:...|..:..|.:|.::::|:..|:::||::...|..|     ||.
  Fly   233 NALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ-----VPTDWTNVSHTDWQIWV 292

Human   366 ---------EDD-PSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 420
                     ||: |..|...|| .|.|....||....:.|.||.||||||.::|||.||.||::.
  Fly   293 NDTDNWLYDEDELPVLCGNLTG-ARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356

Human   421 WTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL---------------------------- 457
            |.:| |.|..|....:...:|..:|.||||:::||:|
  Fly   357 WENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDD 420

Human   458 ---------------------------GVLSGEFSKEREKAK----------------ARGD--- 476
                                       |||...:||::.:.|                :.||
  Fly   421 STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNK 485

Human   477 ------------------------FQKLREKQQLEEDLKGYLDWITQAEDIDPEN---------- 507
                                    .|..::.||:|:..|     :.::......|
  Fly   486 SHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHK-----LAKSGSGGSNNPMAPTPKGRI 545

Human   508 --EDEGMDEEKPRNRGTPA---GMLDQKKGKFAWFSHSTETHVSMPTSETESVNTENV---AGGD 564
              :|.||..:.| |...|:   |.|....|:              |:|.:..||.|:.   :|..
  Fly   546 SFQDSGMGVKNP-NMLYPSDYKGQLIANSGQ--------------PSSNSSGVNRESSQDDSGVV 595

Human   565 IEGENCGARLAKGSRSAVEPAVLLPWGVTTVNSPWPLEELQTE---ALSQTSPSHRISKSKFSR- 625
            .:.|........|..|.||.| |.|..|..:.....:..::..   ||.|...|..:.......
  Fly   596 DDHEEQDTTNDMGHVSTVELA-LSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDR 659

Human   626 ------YW----RRWNRF--CRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD 678
                  :|    ..|.:|  |..|   .|:..:|...:...:.|||..:|.||:..........|
  Fly   660 NCDRCVHWCTDYESWLQFQNCLYK---VVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721

Human   679 TANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETI--LVETKIMSPLGISVLR 741
            ..||...::||.|.::|:.:|. :.:|:..:|.||..:|...:|:.|  ||:       |:||||
  Fly   722 VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLSVLR 778

Human   742 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDEM 803
            .:||||:.|:.:.|.::..|::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||..
  Fly   779 GLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843

Human   804 QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLN 867
            ...|..|::|..|.:.:|:||.|| |...::|.:.|   ....|...|. .|:...:.||:::||
  Fly   844 PVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLN 904

Human   868 VFLAIAVDNLADAESLTSAQKEEEEE------------------KERKKLARTASPEKKQELV-- 912
            :|||:.: |..::|.|.|.::|..||                  :|||........||.|::|
  Fly   905 LFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLD 968

Human   913 --------------------EKPAV-GESK----------------------------------- 921
                                :||.| .|:|
  Fly   969 AQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG 1033

Human   922 ---------EEKIELKS--ITADGESPPAT--------------KIN----MDDLQP-------- 949
                     .|:|:|::  :....:|.|.|              .:|    ..:|.|
  Fly  1034 LEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRL 1098

Human   950 ------------------------------NENEDKSPYPNPETTG------------------- 965
                                          ..:.|..||.|.:.:|
  Fly  1099 QHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYG 1163

Human   966 --------------------------------------------------------------EED 968
                                                                          |:|
  Fly  1164 SEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQD 1228

Human   969 E-------------------------EEPEMPVG------------------------------- 977
            |                         ||.|:..|
  Fly  1229 ELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHS 1293

Human   978 --------------------------------PRP------------------------------ 980
                                            |.|
  Fly  1294 EFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358

Human   981 ----------------------------------------------------------------- 980
                                                                             
  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423

Human   981 ----------------------------------------------------RPLSELHLKEKAV 993
                                                                :|:|.|.::.:.:
  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488

Human   994 P---------------------------------------------------------------- 994
            |
  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553

Human   995 ----------------------------------------------------------------- 994
                                                                             
  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618

Human   995 -----------------------------MPEA----SAF------------------------- 1001
                                         .|:|    |||
  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683

Human  1002 --------FIFSS----------NNRFRLQCH------------------------------RIV 1018
                    ..|.|          ::.|..:|:                              .:|
  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVV 1748

Human  1019 NDTIFTNLILFFILLSSISLAAED-PVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHK 1082
            :...|...:|..|..|||:|..|| .:........:|::.:..|..||.:|:.||..|.|.
  Fly  1749 DTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF---- 1809

Human  1083 GSFCRNYFNILDLLVVSVSLISFGIQSSA-INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVA 1146
            ..:..:::.|||.::|.||:.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..|
  Fly  1810 SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYA 1874

Human  1147 IRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQ----TEAECKGNYITYKDGEVDHPII 1207
            |.:|.|:::|..:...:|:.:|||.|.||.:.|.:...:    ||...|.:.|.
  Fly  1875 IPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE----------- 1928

Human  1208 QPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP-----IYNYRVEISIFF 1267
            |..:|.|||..||:|....:||..|:|||||.|::..::|:...|..|     :|.|     |:|
  Fly  1929 QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYF 1988

Human  1268 IIYIIIIAFFMMNIFVGFVIVTFQ------EQGEQEYKNCELDKNQRQCVEYALKARP---LRRY 1323
            :|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|   ::|.
  Fly  1989 VIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRP 2053

Human  1324 IPKNQHQYKVWY-VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEM 1387
            |   .|...::| :.||..||..:||||.||.:.:.::||.|.......:.:.|..||.:|.:|.
  Fly  2054 I---NHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEA 2115

Human  1388 ILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEV 1452
            |:|::..: ..||:.||||||||:|:.||..:::.:.                   ::|:.|
  Fly  2116 IVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDI-------------------MIDLPI--- 2157

Human  1453 NPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1517
                    ||::         :...|:||:.|:::|:...:|||.||:..:.|..||..:..|:.
  Fly  2158 --------SPTL---------LRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLG 2205

Human  1518 MLFFIYAVIGMQVFGKI----ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM--LACMP 1576
            ::.||||::||.:||.:    ||:|..      |||||.:::.||||..|...|.|::  |...|
  Fly  2206 LITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQP 2264

Human  1577 GKKCAPESEP--SNSTEGETPCGSS-FAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI- 1637
                 |:.:|  ...|.|.  ||.. .|:.||.||.::...::||:::|:|::||:...::..|
  Fly  2265 -----PDCDPFIHGHTNGN--CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIG 2322

Human  1638 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSD 1702
            :....|:.|...|::|||.|...|....:...:..:.||||..|  |:.||   |||.|:|::..
  Fly  2323 IVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKG 2382

Human  1703 GTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKK-------- 1759
            ..:.....|.|||:..|            .|....|      |.:|..|::....||
  Fly  2383 NKIHCLDILHALVKHVL------------GHVEETD------NFKQLQEQMDVKFKKQFPTRKEL 2429

Human  1760 -------IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----EYFRKFKKRKEQ-------- 1805
                   ||||...                     |...||    ||.|: |:.||:
  Fly  2430 EIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRR-KREKERSNSGDSAT 2472

Human  1806 ------GLVGKPSQRNALSLQAGLR--------------------TLHDI-GPEIR---RAISGD 1840
                  |...|.|..|...||...|                    .|.:: ||.:.   ..:||
  Fly  2473 QTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSG- 2536

Human  1841 LTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQ 1905
               .:|:.|.:|:      ::|...:.|.:|   |...::..|.:|...|.
  Fly  2537 ---ADEVVKDIKQ------QNDELGKRGSIF---VEAPRASRRRSFYNFFL-------------- 2575

Human  1906 GDTESPSHEKLVDSTFT-PSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPA 1969
                  .|:..||.:.| ||.:..|..|...|..:|:|     ..:|..|:.:|        :||
  Fly  2576 ------RHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSA-----STSGTASSTAT--------APA 2621

Human  1970 IRVQEVAWKLSSNRMHCCDMLDGGTFPPALGP----RRAPPCLHQQLQGSLAGLREDTPCIVPGH 2030
            ......|...|.:..|  ..:.||:.|.....    |:.|| |.:.|....| ||.:....|
  Fly  2622 TGCGPAATSASDSDRH--QAVGGGSAPSRKRASSFIRKKPP-LERGLSAQSA-LRVNKNAFV--- 2679

Human  2031 ASLCCSSRVGEWLPAGCTAPQHARERHVPMCEDLELRRDSGSAGTQAHCLLLRRANPSRCH---S 2092
                          :..:||            ::.:.|.|....|..|.|.||..|.:..|   .
  Fly  2680 --------------SEASAP------------EVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVH 2718

Human  2093 RESQAAMAGQEETSQDETYEVKMNHDTEACSEPSL--------LSTEMLSYQDDENRQLTLPEED 2149
            |||      :|...:||             |.||:        :..:|||.|.....::|....:
  Fly  2719 RES------EEYKEEDE-------------SSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVE 2764

Human  2150 KR-------------DIRQSPKRGFLRSA---SLGRRASFHLECLKRQKDRGGDISQ--KTVLPL 2196
            ..             |..:.|.||...||   .:|.....:::         ||.||  ....|.
  Fly  2765 SSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQ---------GDTSQVFYDYNPE 2820

Human  2197 HLVHHQALA---VAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLN 2258
            .....|...   .|....|..|...|     |..||......|.          ..|..||....
  Fly  2821 KATDDQGNGQDETAQFESLPDRQRXP-----PVNTPLRDSEKRS----------SRGSRSSSSST 2870

Human  2259 SSFPSIHCGSWAETTPGGGGSSAARR 2284
            ||..|  |.|.:.::.....:.:|||
  Fly  2871 SSIRS--CSSSSSSSAASAAAPSARR 2894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1C	XP_016875415.1	None
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	80/241 (33%)
		Ion_trans	705..902	CDD:278921	62/208 (30%)
		Ion_trans	1768..2019	CDD:278921	86/270 (32%)
		Na_channel_gate	2009..2063	CDD:240441	10/56 (18%)
		Ion_trans	2085..2320	CDD:278921	83/287 (29%)
		GPHH	2331..2386	CDD:293510	20/59 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840