DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF195 and Zfp758

DIOPT Version :9

Sequence 1:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens
Sequence 2:	XP_036016404.1	Gene:	Zfp758 / 224598	MGIID:	2385044	Length:	631	Species:	Mus musculus

Alignment Length:	656	Identity:	233/656 - (35%)
Similarity:	308/656 - (46%)	Gaps:	162/656 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     3 LLTFRDVAIEFSLEEWKCLDLAQQNLYRDVMLENYRNLFSV-GLTVCKPGLITCLEQRKEPWNVK 66
            ||||:|||::||.|||:|||.||:.||.|||||||.|||.| ...:|
Mouse    92 LLTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENHYIC------------------ 138

Human    67 RQEAADGHPEMGFHHATQACLELLGSSDLPASASQSAGITGVNHRAQPGLNVSVDKFTALCSPGV 131
                          |..:..|:                 ....|.....:|:.
Mouse   139 --------------HKYENFLD-----------------QDTQHIVHEDINIK------------ 160

Human   132 LQTVKWFLEFRCIFSLAMSSHFTQDLLPEQGIQDAFPKRILRGYGNCGLDNLYLRKDWESLDECK 196
            |::.|.....:.|:..:.|:.:..: |.:..|:.:               ||...:...:.:.||
Mouse   161 LKSYKCHELAKIIYESSQSTPYKTN-LRDTSIESS---------------NLNRHETGNTREPCK 209

Human   197 LQKDYNGLNQCSS----------------------------TTHSKIFQYNKYVKIFDNFSNLHR 233
            .:...|.||.|||                            .:..|.::.::|.|.|....:|..
Mouse   210 YKNCVNCLNLCSSIGLNQGIHIGKKDDETFYSNQNLMLKQTKSRKKHYKCSEYDKCFIQKGDLRS 274

Human   234 RNISNTGEKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQCSHFTEPENIDTGEK 298
            ....:|||||:||.||.|.|.:.|.|..|||||||||..:|.:|.|.|....:....:.|.:|||
Mouse   275 HQRMHTGEKPYKCSECNKCFTLKSNLGIHQKIHTGKKPYRCFDCDKCFTNKYNLRTHQRIHSGEK 339

Human   299 PYKCQECNN-VIKTCSVLTKNRIYAGGEHYRCEEFGKVFNQCSHLTEHEHGTEEKPCKYEECSSV 362
            ||||.||:. .|:..|::|..||:.|                           |||.|..||...
Mouse   340 PYKCSECDKCFIQKFSLITHQRIHTG---------------------------EKPYKCSECDKC 377

Human   363 FISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPSKHQRNEIGGKPFKCEECDSIFKWFSDLTK 427
            |.:.|.|..                            |||...|.||:||.|||..|.....|:.
Mouse   378 FTNKSDLRG----------------------------HQRVHTGEKPYKCSECDKCFTHKGSLSI 414

Human   428 HKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFRTCSSLSNHKRTHSEEK 492
            |.|:|:|||||||.||.|.:||..:|..|:|||||||||:|.||.|.|...|.|.:||:.|:.||
Mouse   415 HHRLHSGEKPYKCSECDKCFTQKCNLLTHQRIHTGEKPYKCAECDKCFTNRSDLRSHKKIHTGEK 479

Human   493 PYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEECGR 557
            ||.|.||...|.....|:.|::.|:|||||||.||.|.|||..||::|:||||.:|||||.||.:
Mouse   480 PYKCSECDKCFTHKFSLSIHQRLHSGEKPYKCSECDKCFTQKCNLLIHQRIHTEKKPYKCSECDK 544

Human   558 VFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFTQFSHLT 622
            .|:....:..|::.|||||||||.||.|.||..|:||.|:|||||||||||.:|.|.||....|:
Mouse   545 CFIQKCSLLIHQRIHTGEKPYKCAECAKCFTDKSDLINHQRIHTGEKPYKCSECDKCFTHKCSLS 609

Human   623 VHESIH 628
            :|:.||
Mouse   610 IHQGIH 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630	30/60 (50%)
		KRAB	4..43	CDD:279668	28/38 (74%)
		Spacer	76..243		28/194 (14%)
		COG5048	225..629	CDD:227381	179/405 (44%)
		C2H2 Zn finger	246..266	CDD:275368	10/19 (53%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		C2H2 Zn finger	302..345	CDD:275368	9/43 (21%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		C2H2 Zn finger	412..432	CDD:275368	8/19 (42%)
		zf-H2C2_2	424..449	CDD:290200	14/24 (58%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	452..477	CDD:290200	16/24 (67%)
		C2H2 Zn finger	468..488	CDD:275368	9/19 (47%)
		zf-H2C2_2	480..505	CDD:290200	12/24 (50%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..533	CDD:290200	14/24 (58%)
		C2H2 Zn finger	524..544	CDD:275368	11/19 (58%)
		zf-H2C2_2	536..559	CDD:290200	14/22 (64%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		zf-H2C2_2	567..589	CDD:290200	14/21 (67%)
		C2H2 Zn finger	580..600	CDD:275368	11/19 (58%)
		zf-H2C2_2	592..617	CDD:290200	17/24 (71%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
Zfp758	XP_036016404.1	KRAB	92..132	CDD:396083	29/39 (74%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		COG5048	283..615	CDD:227381	172/386 (45%)
		C2H2 Zn finger	287..307	CDD:275368	10/19 (53%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	8/47 (17%)
		C2H2 Zn finger	399..419	CDD:275368	8/19 (42%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	11/19 (58%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		C2H2 Zn finger	567..587	CDD:275368	11/19 (58%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810