DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF195 and Zfp988

DIOPT Version :9

Sequence 1:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens
Sequence 2:	NP_001371161.1	Gene:	Zfp988 / 115489950	MGIID:	3651985	Length:	633	Species:	Mus musculus

Alignment Length:	662	Identity:	271/662 - (40%)
Similarity:	352/662 - (53%)	Gaps:	81/662 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     3 LLTFRDVAIEFSLEEWKCLDLAQQNLYRDVMLENYRNLFSVGLTVC---KPGLITCLEQRK---- 60
            ||||:|||::||||||:||..||::||.|||||||.||..|. ..|   |.|.:  |:|..
Mouse    12 LLTFKDVALDFSLEEWECLSFAQRSLYMDVMLENYNNLLFVE-NHCIRGKNGKV--LDQDSQYIV 73

Human    61 -EPWNVKRQEAADGHPEMGFHHATQACLELLGSSDLPASASQSAGITGVNHRAQPGLNVSVDKFT 124
             |..|::.:.:.       :...:...||.|..:....:.|..|.......|.:|.....|.|:.
Mouse    74 HEHMNIQEKSSK-------WDKLSNVILESLQCTPYKTNHSSDALQFSNQKRLKPRNTKEVCKYN 131

Human   125 ALCSPGVLQTVKWFLEFRCIFSLAMSSHFTQDLLPEQGIQDAFPKRILRGYGNCGLDNLYLRK-- 187
                             ..:.||::.|..:.:    |||.....|.    ..|..|||:::.|
Mouse   132 -----------------DSVNSLSLFSTISLN----QGINMQKKKH----NRNAELDNIFVSKHK 171

Human   188 -----------------------DWESLDECKLQKDYNGLNQCSSTTHSKIFQYNKYVKIFDNFS 229
                                   ..|:|.  ..|:.|:|.....|:...|.|.:..::.|....
Mouse   172 VMVKKDNIAGNPYKCSEFHKYLTQRENLQ--SQQRIYHGKKPYKSSKSDKCFTHQIHLSIHQGI- 233

Human   230 NLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQCSHFTEPENID 294
                    :|.|..:||.||.|.|:....||.||:||||:|..||.||||.|.:.|.....:.|.
Mouse   234 --------HTEEIIYKCSECDKCFKNKFNLTMHQRIHTGEKPYKCSECGKCFTEKSSLRIHQRIH 290

Human   295 TGEKPYKCQECNNVI-KTCSVLTKNRIYAGGEHYRCEEFGKVFNQCSHLTEHEH-GTEEKPCKYE 357
            ||||||||.||:... |..::....||:.|.:.|:|.|..|.|.|.|.|:.|:. .|.|||.|..
Mouse   291 TGEKPYKCSECDKCFTKQSNLSIHQRIHTGEKPYKCSECDKCFTQQSCLSIHQRIHTGEKPYKCS 355

Human   358 ECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPSKHQRNEIGGKPFKCEECDSIFKWF 422
            ||...|...|||...|.|..|||..||....|.|....:...|||...|.||:||.|||..|...
Mouse   356 ECGKCFTEKSSLRIHQRIHTGEKTYKCSECDKCFTRKFHLGIHQRIHTGEKPYKCSECDKCFTQQ 420

Human   423 SDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFRTCSSLSNHKRT 487
            |:||.|:|||||||||||.||||.:|:.|.|..|:|||||||||:|.||||.|...|||..|:|.
Mouse   421 SNLTIHQRIHTGEKPYKCPECGKCFTEKSSLRIHQRIHTGEKPYKCSECGKCFTEKSSLRIHQRI 485

Human   488 HSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKC 552
            |:.||||.|.|||..|.:.|.|..|::.|||||||||.||||.||..|:|.:|:|||||||||||
Mouse   486 HTGEKPYKCNECGKCFTEKSSLRIHQRIHTGEKPYKCSECGKCFTVKSSLRIHQRIHTGEKPYKC 550

Human   553 EECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFTQ 617
            .||.:.|...|:::.|::.|||||||||.||.|.|::..:|.:|:||||||:||||.:|.|.|::
Mouse   551 SECDKCFTKQSNLSIHQRIHTGEKPYKCSECEKCFSRKLHLGIHQRIHTGERPYKCSECEKCFSR 615

Human   618 FSHLTVHESIHT 629
            ..||.:|:.|||
Mouse   616 KFHLGIHQRIHT 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630	34/67 (51%)
		KRAB	4..43	CDD:279668	27/38 (71%)
		Spacer	76..243		32/191 (17%)
		COG5048	225..629	CDD:227381	203/405 (50%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		C2H2 Zn finger	302..345	CDD:275368	15/43 (35%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	10/19 (53%)
		zf-H2C2_2	424..449	CDD:290200	18/24 (75%)
		C2H2 Zn finger	440..460	CDD:275368	10/19 (53%)
		zf-H2C2_2	452..477	CDD:290200	17/24 (71%)
		C2H2 Zn finger	468..488	CDD:275368	11/19 (58%)
		zf-H2C2_2	480..505	CDD:290200	14/24 (58%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		zf-H2C2_2	508..533	CDD:290200	16/24 (67%)
		C2H2 Zn finger	524..544	CDD:275368	11/19 (58%)
		zf-H2C2_2	536..559	CDD:290200	15/22 (68%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		zf-H2C2_2	567..589	CDD:290200	14/21 (67%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
		zf-H2C2_2	592..617	CDD:290200	15/24 (63%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
Zfp988	NP_001371161.1	KRAB	12..52	CDD:396083	28/39 (72%)
		C2H2 Zn finger	186..206	CDD:275368	3/21 (14%)
		C2H2 Zn finger	218..234	CDD:275368	3/24 (13%)
		COG5048	240..607	CDD:227381	193/366 (53%)
		C2H2 Zn finger	242..262	CDD:275368	9/19 (47%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		C2H2 Zn finger	326..346	CDD:275368	8/19 (42%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		C2H2 Zn finger	438..458	CDD:275368	10/19 (53%)
		C2H2 Zn finger	466..486	CDD:275368	11/19 (58%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
		C2H2 Zn finger	522..542	CDD:275368	11/19 (58%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	8/19 (42%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810