DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF195 and LOC103910897

DIOPT Version :9

Sequence 1:	NP_001123992.1	Gene:	ZNF195 / 7748	HGNCID:	12986	Length:	629	Species:	Homo sapiens
Sequence 2:	XP_021331401.1	Gene:	LOC103910897 / 103910897	-ID:	-	Length:	1691	Species:	Danio rerio

Alignment Length:	468	Identity:	206/468 - (44%)
Similarity:	269/468 - (57%)	Gaps:	28/468 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   187 KDWESLDECKL-------QKDY------NGLNQCSSTTHSK----------IFQYNKYVKIFDNF 228
            |.|....:.|:       :|.:      ...|:.|...|.|          ..|..|......||
Zfish   409 KSWTRKSKLKIHMIIHTGEKPFTCTQCGRSFNRSSHLNHHKRIHTGEKPIRCTQCGKSFSQSSNF 473

Human   229 SNLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQCSHFTEPENI 293
             |||.|  .:||||||.|.:|||||:..|.|.:|.:.|||:|...|.:|||:|.:.|...:...|
Zfish   474 -NLHMR--IHTGEKPFTCTQCGKSFRQASSLNKHMRTHTGEKPFTCTQCGKSFNRSSTLNQHIRI 535

Human   294 DTGEKPYKCQECNNVIKTCSVLTKN-RIYAGGEHYRCEEFGKVFNQCSHLTEHEH-GTEEKPCKY 356
            .|||||..|.:|....:..|.|.|: ||:.|.:.:.|.:.||.|:|.|:...|.. .|.|||.:.
Zfish   536 HTGEKPIPCTQCGKSFRQSSSLYKHMRIHTGEKPFTCTQCGKSFSQSSNFNLHMRIHTGEKPIRC 600

Human   357 EECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPSKHQRNEIGGKPFKCEECDSIFKW 421
            .:|...|...|||.....|..|||...|....|.|..:.:.:||.|...|.|||.|.:|...|..
Zfish   601 TQCGKSFHQSSSLYKHMRIHTGEKPFTCTQCGKSFRQASSLNKHMRIHTGEKPFTCTQCGISFNC 665

Human   422 FSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFRTCSSLSNHKR 486
            .|.|.:|.||||||||:.|.:||:::.:||||:.|.||||||||:.|.:|||.|...|:|:.|.|
Zfish   666 SSYLKQHMRIHTGEKPFTCTQCGRSFNRSSHLNHHMRIHTGEKPFTCTQCGKSFNRSSNLNQHIR 730

Human   487 THSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYK 551
            .|:.|||.||..||..|:|.|.|:||.:|||||||:.|.:|||:|:||||..:|.||||||||:.
Zfish   731 IHTGEKPITCTLCGKSFRQSSSLSKHMRTHTGEKPFTCTQCGKSFSQSSNFNLHMRIHTGEKPFT 795

Human   552 CEECGRVFMWFSDITKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFT 616
            |.:||:.|...|.:.||.:|||||||:.|.:|||:|.:||:|..|.||||||||..|.:|||:|.
Zfish   796 CTQCGKSFRQASSLNKHTRTHTGEKPFTCTQCGKSFNRSSHLNQHIRIHTGEKPITCTQCGKSFR 860

Human   617 QFSHLTVHESIHT 629
            |.|.|..|..|||
Zfish   861 QSSSLYKHMRIHT 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF195	NP_001123992.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		Spacer	76..243		19/78 (24%)
		COG5048	225..629	CDD:227381	194/405 (48%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		C2H2 Zn finger	302..345	CDD:275368	14/43 (33%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..449	CDD:290200	13/24 (54%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	452..477	CDD:290200	16/24 (67%)
		C2H2 Zn finger	468..488	CDD:275368	9/19 (47%)
		zf-H2C2_2	480..505	CDD:290200	12/24 (50%)
		C2H2 Zn finger	496..516	CDD:275368	9/19 (47%)
		zf-H2C2_2	508..533	CDD:290200	15/24 (63%)
		C2H2 Zn finger	524..544	CDD:275368	11/19 (58%)
		zf-H2C2_2	536..559	CDD:290200	13/22 (59%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		zf-H2C2_2	567..589	CDD:290200	14/21 (67%)
		C2H2 Zn finger	580..600	CDD:275368	10/19 (53%)
		zf-H2C2_2	592..617	CDD:290200	15/24 (63%)
		C2H2 Zn finger	608..628	CDD:275368	9/19 (47%)
LOC103910897	XP_021331401.1	C2H2 Zn finger	68..88	CDD:275368
		zf-H2C2_2	81..105	CDD:316026
		C2H2 Zn finger	96..116	CDD:275368
		zf-H2C2_2	108..133	CDD:316026
		C2H2 Zn finger	124..144	CDD:275368
		zf-H2C2_2	137..161	CDD:316026
		C2H2 Zn finger	152..172	CDD:275368
		zf-H2C2_2	164..189	CDD:316026
		C2H2 Zn finger	180..200	CDD:275368
		zf-H2C2_2	192..217	CDD:316026
		C2H2 Zn finger	208..228	CDD:275368
		zf-H2C2_2	220..245	CDD:316026
		C2H2 Zn finger	236..256	CDD:275368
		COG5048	260..700	CDD:227381	106/293 (36%)
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	404..424	CDD:275368	3/14 (21%)
		C2H2 Zn finger	432..452	CDD:275368	4/19 (21%)
		C2H2 Zn finger	460..480	CDD:275368	8/22 (36%)
		C2H2 Zn finger	488..508	CDD:275368	9/19 (47%)
		COG5048	512..925	CDD:227381	172/362 (48%)
		C2H2 Zn finger	516..536	CDD:275368	6/19 (32%)
		C2H2 Zn finger	544..564	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		C2H2 Zn finger	684..704	CDD:275368	9/19 (47%)
		C2H2 Zn finger	712..732	CDD:275368	9/19 (47%)
		C2H2 Zn finger	740..760	CDD:275368	9/19 (47%)
		C2H2 Zn finger	768..788	CDD:275368	11/19 (58%)
		C2H2 Zn finger	796..816	CDD:275368	7/19 (37%)
		C2H2 Zn finger	824..844	CDD:275368	10/19 (53%)
		C2H2 Zn finger	852..872	CDD:275368	9/19 (47%)
		C2H2 Zn finger	880..900	CDD:275368
		COG5048	930..1340	CDD:227381
		C2H2 Zn finger	935..955	CDD:275368
		C2H2 Zn finger	963..983	CDD:275368
		C2H2 Zn finger	991..1011	CDD:275368
		C2H2 Zn finger	1019..1039	CDD:275368
		C2H2 Zn finger	1047..1067	CDD:275368
		C2H2 Zn finger	1075..1095	CDD:275368
		C2H2 Zn finger	1103..1123	CDD:275368
		C2H2 Zn finger	1131..1150	CDD:275368
		C2H2 Zn finger	1158..1178	CDD:275368
		C2H2 Zn finger	1186..1206	CDD:275368
		C2H2 Zn finger	1214..1234	CDD:275368
		C2H2 Zn finger	1242..1262	CDD:275368
		COG5048	1266..1670	CDD:227381
		C2H2 Zn finger	1270..1290	CDD:275368
		C2H2 Zn finger	1298..1318	CDD:275368
		C2H2 Zn finger	1326..1346	CDD:275368
		C2H2 Zn finger	1354..1374	CDD:275368
		C2H2 Zn finger	1382..1402	CDD:275368
		C2H2 Zn finger	1410..1430	CDD:275368
		C2H2 Zn finger	1438..1458	CDD:275368
		C2H2 Zn finger	1466..1486	CDD:275368
		C2H2 Zn finger	1522..1542	CDD:275368
		C2H2 Zn finger	1550..1570	CDD:275368
		C2H2 Zn finger	1578..1598	CDD:275368
		C2H2 Zn finger	1606..1626	CDD:275368
C2H2 Zn finger	1634..1654	CDD:275368
C2H2 Zn finger	1662..1682	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900