DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF189 and CG15436

DIOPT Version :9

Sequence 1:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens
Sequence 2:	NP_608840.1	Gene:	CG15436 / 33657	FlyBaseID:	FBgn0031610	Length:	346	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	106/325 - (32%)
Similarity:	156/325 - (48%)	Gaps:	49/325 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    66 VKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQRGIFLWEIPRESLTQEQRMF 130
            ::|..||..:       ...|::.|..:|       .|...|:::.    |||..:
  Fly    65 IRQTCEESHQ-------FYCRVRDEGIED-------ALCALLEEED----WEISED--------- 102

Human   131 RENTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQ 195
             |:..|        :.....::.||...:|.             .|:|.||.|.:.|....:.|.
  Fly   103 -EDARI--------DSASAADDDGKSDSKKV-------------AFECRECHKKYQRKGTFLRHM 145

Human   196 RIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPH 260
            |.|...:.:.|.||.:.|.:..||..|.:.|...:||:|:.|.::|:|:.:|..|:|.||||:|.
  Fly   146 RTHMDGQSFPCPYCKRNFRLRVTLKAHMKTHNAAKPYECSHCAKTFAQQSTLQSHERTHTGERPF 210

Human   261 KCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAF 325
            |||.|.|.|...|.|..|.|||..|:|:.|:||.|:|:|...|..|.|.||||||.||..|.|||
  Fly   211 KCSQCSKTFIKSSDLRRHIRTHGSERPFKCSKCTKTFTRKFHLDNHFRSHTGERPFKCSHCPKAF 275

Human   326 RLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRH 390
            .:..:|.||.::|..::||.|..|.|:|..||.|.||:.:|..||.::|..|...:.|...|.||
  Fly   276 AMKQHLKQHSRLHLPDRPFRCSHCPKTFRLSSTLKEHKLVHNAERTFKCPHCASFYKQRKTLARH 340

Human 391 390
Fly 341 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083
		COG5048	138..524	CDD:227381	93/253 (37%)
		C2H2 Zn finger	150..170	CDD:275368	3/19 (16%)
		C2H2 Zn finger	178..198	CDD:275368	7/19 (37%)
		C2H2 Zn finger	206..226	CDD:275368	7/19 (37%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	9/19 (47%)
		C2H2 Zn finger	290..310	CDD:275368	9/19 (47%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	9/19 (47%)
		C2H2 Zn finger	374..394	CDD:275368	6/17 (35%)
		C2H2 Zn finger	402..422	CDD:275368
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		C2H2 Zn finger	514..534	CDD:275368
		zf-H2C2_2	526..551	CDD:404364
		C2H2 Zn finger	542..562	CDD:275368
		zf-H2C2_2	555..579	CDD:404364
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
CG15436	NP_608840.1	zf-AD	4..78	CDD:285071	3/19 (16%)
		C2H2 Zn finger	128..148	CDD:275368	7/19 (37%)
		C2H2 Zn finger	156..176	CDD:275368	7/19 (37%)
		COG5048	<180..341	CDD:227381	73/161 (45%)
		C2H2 Zn finger	184..204	CDD:275368	7/19 (37%)
		zf-H2C2_2	197..219	CDD:290200	13/21 (62%)
		C2H2 Zn finger	212..232	CDD:275368	9/19 (47%)
		zf-H2C2_2	224..249	CDD:290200	12/24 (50%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		zf-H2C2_2	252..276	CDD:290200	14/23 (61%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..341	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910