DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CACNA1B and NaCP60E

DIOPT Version :9

Sequence 1:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:3013 Identity:643/3013 - (21%)
Similarity:1081/3013 - (35%) Gaps:964/3013 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136

Human   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189

Human   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253

Human   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTD--AEPVGDFP--CGKEAPARLC 277
            ::||:..|:.|||:....|                  :.|.||  .....:.|  ||....||.|
  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318

Human   278 EGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382

Human   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447

Human   397 EVMLAEEDR-----------------------NAEEK-------SPLDVLKRAATKK-------- 423
            .|:||...:                       |.::.       ||....:.:||::        
  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512

Human   424 --------------------SRNDLIHAEEGEDRFAD--------------------LCAVGSPF 448
                                |.|.:....:|...|.|                    :...|.| 
  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576

Human   449 ARASLKSGKTESSS--------------------------------------------------- 462
              :|..||....||                                                   
  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639

Human   463 YFRRKE-----------------------------KMFRFFIRRMVKAQSFYWVVLCVVALNTLC 498
            |...:|                             ..|:..:.::|:...|...:...:.|||..
  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704

Human   499 VAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVW 563
            :||.|:.........|.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768

Human   564 AAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628
            ..:.     |:||||.|||||:.|:.:.|::::.|:..:::::.::.:|..:|.:.|.:||::||
  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828

Human   629 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 689
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890

Human   690 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANIS 753
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.:::..          
  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIR---------- 944

Human   754 IAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEM-------DPEERLRFATTRHLRPDMKT 811
             ..||:...:....:.::..|:.|...:|..:.|..:.       |....|  |.|:..|...:.
  Fly   945 -KKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVL--AETKFHRLSYQE 1006

Human   812 HLDRPLV-VELG-----RDGARGPVGGKARPEAAEAPEGVD-------------PP--------- 848
            .::||:. .:.|     .||....|.|....:..:.||.:.             ||         
  Fly  1007 SMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMAT 1071

Human   849 -------------------------RRHH---------------------------RHRDKDKTP 861
                                     |..|                           ::...|..|
  Fly  1072 TGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDP 1136

Human   862 AAGDQ-------DRAEAPKAESGEPGAREERPR-------------PHRSHSKEAAGPPEARSER 906
            .|.||       :|.::.:..|......||...             |....|.:.......:|:|
  Fly  1137 YANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQR 1201

Human   907 GRGPGPEGGRRHHRRG------------------------------------SPEEAAEREPRRH 935
            ......|...|.|..|                                    ..||..::..:..
  Fly  1202 SLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLR 1266

Human   936 R---AHRHQDPSKECAGAKGERRARH-----------------RGGPRAGPREAESGEEPARRHR 980
            |   ..|.:.||.:....:.|....|                 :....:..|:..:..||:....
  Fly  1267 RISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAAD 1331

Human   981 ARHKAQPAHEAVEKETTEKEATE------------------KEAEIVEA---------------- 1011
            ...||...|.|:....:|:.|.:                  :.::.|.|                
  Fly  1332 EATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEK 1396

Human  1012 ----DKEKELRNH------QPREPHCDLETSGTVTVGPMHTLPS--------------------- 1045
                |::..:.|.      |...|...:|.............|:                     
  Fly  1397 QRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKR 1461

Human  1046 -TCLQKVEEQPED----------------------------------ADNQRNV----TRMG--- 1068
             :.:::|||.||:                                  .::..|:    .::|   
  Fly  1462 LSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMAT 1526

Human  1069 -----SQPP-------DPNTIVHIPVMLTGP----LGE------ATVV----------------- 1094
                 :.||       :|.|:..|..:.|.|    |.|      ||.:                 
  Fly  1527 PPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHA 1591

Human  1095 ------------PSGNVD---------LESQAEGKKEVEA------------------------- 1113
                        |...:|         .||.:.|..:..:                         
  Fly  1592 HSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPS 1656

Human  1114 -----------------DDVMRSG----------PRPIVPYSS---------------------- 1129
                             ||:...|          |.....|.:                      
  Fly  1657 AFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFR 1721

Human  1130 ----MFCLSPTNL-----LRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALK- 1184
                |.|:...:.     :|.....:|....||..:||:|..|||.|..|| :..|  :|..|| 
  Fly  1722 CPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED-INLD--KNKTLKR 1783

Human  1185 ---YLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINT 1246
               ::::.|..:|..||::|.:.||.    ..||...|.|||||:|  .:..|:....:.:::..
  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV--FVSVFSLLIEENENLKV 1842

Human  1247 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC 1311
            ::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::.||.|.||||.|
  Fly  1843 LRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKC 1907

Human  1312 TDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWP 1368
            .:|..||        :.||           :| |...|......:|:|....|.|..|:|.|||.
  Fly  1908 VNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKITFDHVGMGYLALLQVATFEGWM 1960

Human  1369 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVF----PFFFVNIFVALIIITF---QEQGDKV 1426
            .|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||..|   :::.:..
  Fly  1961 EVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGG 2021

Human  1427 MSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPP----------------FEY 1475
            :.|..|.::::   .:..:.|.|.|..||.           |:..|                ||.
  Fly  2022 VLEMFLTESQK---HYYTAMKKLGRKKPQK-----------VIKRPINHFLAMFYDLSNSRRFEI 2072

Human  1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDF 1540
            .|..:|.||.:.:.::.||.|:....:|:..|..||::|.:|.::||:... .:||...||||||
  Fly  2073 AIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDF 2136

Human  1541 VTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQSFKA 1598
            :.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.||:..|.|..|
  Fly  2137 LLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPA 2196

Human  1599 LPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHE 1659
            |..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||||..|...|::
  Fly  2197 LFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWND 2255

Human  1660 IMLSCLSNQA-CDE----QANATECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1718
            ::.|.:.... ||.    ..|. .||.. .|..||.|||.:...:::|:::|:|::||....::.
  Fly  2256 VLESLMIQPPDCDPFIHGHTNG-NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEE 2319

Human  1719 SI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPI 1782
            .| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||   ||..|:||
  Fly  2320 EIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPI 2379

Human  1783 SNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAEL------RKEISVV-----WANLPQ 1834
            |..: .:|....|.||::..|.........|  |.|.|.:.      |||:.:|     |....:
  Fly  2380 SKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK 2443

Human  1835 --KTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQ--APGG-LSQMGPVSLFHPLK 1894
              ||:           .|..|.|   :.....|:...:.|...|  :||| .|::..::.|| |:
  Fly  2444 AAKTI-----------QTGWKEY---LRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH-LQ 2493

Human  1895 ATLEQTQPAVLRGARVFLRQKSSTSLSN-GGAIQNQE----SGIKESVSWGTQRTQDAPHEARPP 1954
            .:...|..:....:|...|...::.||. .|...|..    ||..|.|....|:..:        
  Fly  2494 VSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDE-------- 2550

Human  1955 LERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTD---AS 2016
                      :|:.|::.|:....|                  |..|........|...|   .|
  Fly  2551 ----------LGKRGSIFVEAPRAS------------------RRRSFYNFFLRHQDAVDDSLTS 2587

Human  2017 P-------MKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLS 2074
            |       |..:.:|.:.....:...|:|...|...          |             ||:.:
  Fly  2588 PSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATG----------C-------------GPAAT 2629

Human  2075 ADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREP- 2138
            :..|.....|||.|..|..........::...|||.|.:    |:....|..|.|    ....| 
  Fly  2630 SASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQ----SALRVNKNAFVS----EASAPE 2686

Human  2139 ---PKPKPSLSSHPTSPT---------------AGQEPGPHPQGSGSVNGSPLLSTSGASTPGRG 2185
               .:|.|...:||.|.:               ..:|.....:.|.||:|:           |.|
  Fly  2687 VIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGN-----------GNG 2740

Human  2186 ---GRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP 2247
               |...|.:.| .|:..||..:..||....|.....:...||....||          |..|.|
  Fly  2741 FGVGLDMLSKQP-PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRG----------DFSSAP 2794

Human  2248 L----AP-----------------GSRIGSDPYLGQRLDSEASVHALPE--------DTLTFEEA 2283
            :    ||                 ..:...|...||  |..|...:||:        ..|...|.
  Fly  2795 IDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQ--DETAQFESLPDRQRXPPVNTPLRDSEK 2857

Human  2284 VATNSGR--SSRTSYVSSLTSQS 2304
            .::...|  ||.||.:.|.:|.|
  Fly  2858 RSSRGSRSSSSSTSSIRSCSSSS 2880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
I 82..359 99/299 (33%)
Ion_trans 112..367 CDD:278921 91/279 (33%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 3/25 (12%)
II 468..712 67/277 (24%)
Ion_trans 499..720 CDD:278921 64/225 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 53/421 (13%)
DUF3628 <822..929 CDD:289100 30/241 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 7/74 (9%)
III 1137..1419 93/302 (31%)
Ion_trans 1167..1425 CDD:278921 84/276 (30%)
IV 1456..1711 89/287 (31%)
Ion_trans 1488..1719 CDD:278921 83/247 (34%)
GPHH 1727..1791 CDD:293510 21/63 (33%)
Ca_chan_IQ 1793..1867 CDD:285917 19/88 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 47/256 (18%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/220 (35%)
Ion_trans 705..902 CDD:278921 55/205 (27%)
Ion_trans 1768..2019 CDD:278921 84/275 (31%)
Na_channel_gate 2009..2063 CDD:240441 10/67 (15%)
Ion_trans 2085..2320 CDD:278921 83/247 (34%)
GPHH 2331..2386 CDD:293510 21/60 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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