DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF180 and CG11247

DIOPT Version :9

Sequence 1:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	112/325 - (34%)
Similarity:	162/325 - (49%)	Gaps:	14/325 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   349 EEKPFECNQCGKSFSWSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQRT-HTGEKPYRCN 412
            :.|...|:||.|.|...:.|..|...|:.|:|::|.:||||:.::.:|.:|..| |...|.:.|:
  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153

Human   413 QCGKSFSQSYVLVVHQRTHTGEKPYECNQCGKSFRQSYKLIAHQRTH--TGEKPYECNQCGKSFI 475
            ||.|||:....|.:|.|.|:|||||.|:.|.|.|.:..:|..|..:|  |..:.:.|.:|..||.
  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218

Human   476 QSYKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAH-QRTHTGEKPFECNQCGKSFSWSSQLVAH 539
            .:..|..|...|.....:.|:.|...|:....|.|| .:.|.....|||..|.|.......|..|
  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATH 283

Human   540 QRTHTGEKPYECSECGKSFNRSSHLVMHQRIHTGEKPYECNQCGKSFSQSYVLVVHQRTHTGEKP 604
            .:.||..|.:.|..|...|.:.|...:|.|:||||:||:|..|.::|:.|.||.:|.|.||||||
  Fly   284 MQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKP 348

Human   605 YECSQCGK--SFRQSSCLTQH-QRTHTGEKPFECNQCGKTFSLSARLIVHQRTH------TGEKP 660
            :.|..|..  :|.|.:.|..| ::.|..:||:.|..|...|.:...|..|.. |      .|:||
  Fly   349 FRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGDKP 412

Human 661 660
Fly 413 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630
		KRAB	72..111	CDD:279668
		C2H2 Zn finger	249..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		COG5048	332..692	CDD:227381	112/325 (34%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..392	CDD:290200	10/24 (42%)
		C2H2 Zn finger	383..403	CDD:275368	8/20 (40%)
		zf-H2C2_2	395..420	CDD:290200	11/25 (44%)
		C2H2 Zn finger	411..431	CDD:275368	9/19 (47%)
		zf-H2C2_2	424..448	CDD:290200	13/23 (57%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..476	CDD:290200	7/22 (32%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	483..504	CDD:290200	5/20 (25%)
		C2H2 Zn finger	495..515	CDD:275368	6/20 (30%)
		zf-H2C2_2	508..531	CDD:290200	9/23 (39%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..560	CDD:290200	8/23 (35%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		zf-H2C2_2	563..588	CDD:290200	11/24 (46%)
		C2H2 Zn finger	579..599	CDD:275368	8/19 (42%)
		zf-H2C2_2	592..616	CDD:290200	12/25 (48%)
		C2H2 Zn finger	607..627	CDD:275368	6/22 (27%)
		zf-H2C2_2	620..643	CDD:290200	7/23 (30%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..670	CDD:290200	6/19 (32%)
		C2H2 Zn finger	663..683	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/157 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000