DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF112 and atl1

DIOPT Version :9

Sequence 1:	XP_006721634.1	Gene:	RNF112 / 7732	HGNCID:	12968	Length:	639	Species:	Homo sapiens
Sequence 2:	XP_005157066.1	Gene:	atl1 / 571909	ZFINID:	ZDB-GENE-030131-8003	Length:	559	Species:	Danio rerio

Alignment Length:	441	Identity:	109/441 - (24%)
Similarity:	183/441 - (41%)	Gaps:	80/441 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   127 QETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQ 191
            :|....||.|:.::.:.......|...|:::.|.....||..|..::|.|....|||||::.:|:
Zfish    26 EEEADGRARPVQVLVVKDDHTFELDEAALSKILLSEEVRDREVVAISVAGAFRKGKSFLMDFMLR 90

Human   192 GLPGLES----GEGGRPRGGEASLQGCRW--GANGLARGIWMWSHPFLLGK-EGKKVAVFLVDTG 249
            .:....|    |:...|      |.|..|  |:.....||.:||..||:.| :|.||||.|:||.
Zfish    91 YMYSQASEKWLGDAEEP------LTGFSWRGGSERETTGIQIWSEVFLVDKPDGSKVAVLLMDTQ 149

Human   250 DAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLD 314
            .....:.:......:.||:||:||.|:.:.||.:::.||.:|::|.....:..:...:.|.|.|.
Zfish   150 GTFDSQSTLRDSATVFALSTMISSMQVYNISQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLI 214

Human   315 LLVRDSSHPNKAGQGHVGNI-FQSTPLAASQRLSGRYPKVQELLQG--KRARCCLLPAPGRRRMN 376
            .||||.|.|.:...|..|.: |....|..|:........|::.:..  ....|.|:|.||.:...
Zfish   215 FLVRDWSFPYEFPYGQEGGMKFLEKRLKISENQHEELQNVRKHIHSCFTNISCFLMPHPGLKVAT 279

Human   377 QGH--ASPGDTDDDFRHLLGAYVSDVLSAAPQH--------AKSRCQG---YWNEGRAVARGD-- 426
            ..|  ....:.|.:|.:.|...|..:|  .|::        :|..|:|   |:.....:.:|:
Zfish   280 NPHFDGRLREIDQEFINNLQVLVPCLL--RPKNLDVKEINGSKITCRGLVEYFKAYIKIYQGEEL 342

Human   427 ---RRLLTGQQLAQEIKNLSGWMGR-----------TGPG--FTSPDEMAAQLHDLRK------- 468
               :.:|   |...|..||:...|.           :|..  |.:|.|:.|:..::|:
Zfish   343 PHPKSML---QATAEANNLAAVAGAKDLYNRKMEVVSGGDRPFLAPSELQARHLEIREEALALFR 404

Human   469 -------VEAAKRE-----------FEEYVRQQDVATKRIFSALRVLPDTM 501
                   .|.::|.           |.:|::..|  :|.||.|.|. |.|:
Zfish   405 SVKKMGGEEFSRRYLLQLETEIDELFVQYIKHND--SKNIFHAART-PATL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093
RNF112	XP_006721634.1	GBP	163..402	CDD:206650	71/250 (28%)
atl1	XP_005157066.1	P-loop_NTPase	44..306	CDD:304359	74/267 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810