DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF112 and gbp4

DIOPT Version :9

Sequence 1:	XP_006721634.1	Gene:	RNF112 / 7732	HGNCID:	12968	Length:	639	Species:	Homo sapiens
Sequence 2:	NP_001038355.1	Gene:	gbp4 / 559296	ZFINID:	ZDB-GENE-060531-46	Length:	618	Species:	Danio rerio

Alignment Length:	172	Identity:	48/172 - (27%)
Similarity:	73/172 - (42%)	Gaps:	36/172 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   135 EPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESG 199
            :|:.|:...:.|.|.::..|: :.|:.   ...||.::||:|...:|||||:|.|.....|....
Zfish     3 KPVCLIDTGSDGKLCVQQAAL-QVLQQ---IQQPVVVVAVVGPYRTGKSFLMNRLAGKRTGFALS 63

Human   200 EGGRPRGGEASLQGCRWGANGLARGIWMW--SHPFLLGKEGKKVAVFLVDT---GDAMSPELSRE 259
            ...:|:                ..|||||  .||...|     ..:.|:||   ||....:..|:
Zfish    64 SNIKPK----------------TEGIWMWCVPHPTKAG-----TTLVLLDTEGLGDVEKGDSKRD 107

Human   260 TRIKLCALTTMLSS---YQILSTSQELKDTDLDYL-EMFVHV 297
            |.|  .:||.:|||   |....|...|....|.|: |:..|:
Zfish   108 TYI--FSLTVLLSSTLVYNSWGTIDNLAIEQLQYVTELIEHI 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093
RNF112	XP_006721634.1	GBP	163..402	CDD:206650	42/144 (29%)
gbp4	NP_001038355.1	P-loop_NTPase	40..272	CDD:304359	38/131 (29%)
		GBP_C	280..>402	CDD:303769
		CARD_ASC_NALP1	532..614	CDD:260039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810