Protein Alignment RNF112 and rnf112

DIOPT Version :10

• Sequence 1: XP_006721634.1
• Gene: RNF112 / 7732
• HGNCID: 12968
• Length: 639
• Species: Homo sapiens
• Sequence 2: XP_012825846.2
• Gene: rnf112 / 548585
• XenbaseID: XB-GENE-920329
• Length: 611
• Species: Xenopus tropicalis
• Alignment Length: 635
• Identity: 197/635 - (31%)
• Similarity: 287/635 - (45%)
• Gaps: 99/635 - (15%)

Human    13 HRLGK-RERKQSFMGNSGNSWSHTPFPKLELGLGPQPMAPR----------ELPTCSICLERLRD 66
            :|.|| |:||......:|:|           |.......|:          |..||||||:.|.|
 Frog    22 NRRGKRRQRKPKNPAGAGDS-----------GAASSAQQPQYREDSFSSLTEDITCSICLDDLTD 75

Human    67 PISLDCGHDFCIRCFSTHRLPGCEPP---CCPECRKIC----------------KQKRGLRSLGE 112
            |:.:.|||.||..|.:||.  |...|   .|||||..|                |.|:|::....
 Frog    76 PVYIACGHTFCRGCITTHW--GTPHPHGYLCPECRASCPRNHIVPDYRLGNLVSKIKQGIQERNA 138

Human   113 KMK-LLPQRPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLG 176
            ..: ||...|            ..|:.||..:.||.|.|.......|..:......||.||.::|
 Frog   139 MQEHLLAMEP------------DHPIQLVWADRSGRLNLNQSEACDCFLNTQYSHYPVFLLCIIG 191

Human   177 EQHSGKSFLLNHLLQGLPGLESGEGGRPRGGEASLQGCRW--GANGLARGIWMWSHPFLLGKEGK 239
            |:..|||||:|::::.|..:|.||.......:.:|:|..|  |.....:|||||:.||:|..:|.
 Frog   192 EKRRGKSFLMNYIMRALRSMEMGEEFTLGADDEALKGFEWSPGTESTTKGIWMWNRPFILDHKGG 256

Human   240 KVAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKH 304
            |.||||:||..::.....|||.|||.||:..|||:.|.:.:..||:|:|||:||:::    ||:.
 Frog   257 KTAVFLLDTEGSLDIGSDRETCIKLSALSLFLSSHLIFNVASNLKETELDYMEMYLN----MGEE 317

Human   305 YGMVPIQHLDLLVRDSSHPNKAGQGHVGNIFQSTPLAASQRLSGRYPKVQELLQGKRARCCLLPA 369
            ||...:||||:|||| .:.:|.....|.:.:.|..:...|:.:. ||||...|:..:.||.|||.
 Frog   318 YGTQNLQHLDILVRD-WYNSKKWDRDVAHFYISREIENLQQRNS-YPKVLWSLKSNQTRCFLLPH 380

Human   370 PGRRRMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQ 434
            ||:....:......|.|:||:..|.:||.:|:.....|.|....|             .:||...
 Frog   381 PGKGITGESKGRLQDMDEDFQESLRSYVYEVIRVVCTHIKLNVYG-------------EILTSAH 432

Human   435 LAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRVLPD 499
            :...:|.....:.|...||:||.||...:.:.|.:...:.||||:::.|...|         ||.
 Frog   433 IFSMLKEFMEVLDRQKYGFSSPMEMFYAIKNQRLMGDIENEFEEFLKNQSSLT---------LPP 488

Human   500 TMRNLLSTQKDAILARHGVALL---CKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGA 561
            |:|...|.:...:|.::..:||   ...|:..|..||..|....:.|...:|.||..:...||..
 Frog   489 TLRVKASEKYSELLVKYQQSLLGNSTSSREAMLMDLEVALLKRQEKFCSDFTTRFTMNAVGVGIT 553

Human   562 VGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAG 611
            .|.|:.|:.|          |.||...:|.|...|.|||...|...|.:|
 Frog   554 AGLGVYGVLG----------AAAARGTVVLATQPVVATGGRAVAMEVASG 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING-HC_RNF112	53..104	CDD:438200	27/69 (39%)
		GBP	163..402	CDD:206650	92/240 (38%)
rnf112	XP_012825846.2	RING_Ubox	58..111	CDD:473075	25/54 (46%)
		GBP	182..408	CDD:206650	89/231 (39%)