DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNF112 and gbp1

DIOPT Version :9

Sequence 1:XP_006721634.1 Gene:RNF112 / 7732 HGNCID:12968 Length:639 Species:Homo sapiens
Sequence 2:NP_001002343.1 Gene:gbp1 / 436615 ZFINID:ZDB-GENE-040718-32 Length:621 Species:Danio rerio


Alignment Length:502 Identity:106/502 - (21%)
Similarity:171/502 - (34%) Gaps:164/502 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   136 PLLLVRINASGGLILRMGAINRCLKHPLAR-DTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESG 199
            |:.||. |.:|.|.:...||:.     |:. :.||.:::|:|...:|||:|:|.|.....|...|
Zfish    10 PICLVE-NVNGSLSICKDAIDF-----LSNINEPVVVVSVVGLYRTGKSYLMNRLAGQQTGFALG 68

Human   200 EGGRPRGGEASLQGCRWGANGLARGIWMW--SHPFLLGKEGKKVAVFLVDT---GDAMSPELSRE 259
            .                ......:|||||  .||   .|:|.  .:.|:||   ||....:...:
Zfish    69 N----------------TIESKTKGIWMWCVPHP---KKQGH--TLVLLDTEGLGDVDKGDSKND 112

Human   260 TRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAE------------------------- 299
            ..| .| |..:|||..:.::...:.::.|:.|.....:.|                         
Zfish   113 GWI-FC-LAVLLSSTLVYNSRGTIDNSALEKLHYITELTEQIKIRTAEAADEEDEEDSKFVLFFP 175

Human   300 --------------VMGKHYGMVPIQHLDLLVRDSSHPNKAGQGH------VGNIFQST-----P 339
                          :.||:..  ..|:||..::.....||....:      :.|.|.|.     |
Zfish   176 SFTWVVRDFTLDLVIDGKNVN--EDQYLDFALQLRKGNNKKALEYNLPRQCIRNYFPSRKCFVFP 238

Human   340 LAASQRLSGRYPKVQEL--LQGKRARCCLLPAPGR-----------RRMNQGHASPGDTDDDFRH 391
            ..||..      |:::|  ||.|......|...||           :.:..||...|..   ..|
Zfish   239 SPASPE------KMKQLESLQEKDLVPDFLEVTGRFCEHIFRNSVVKTLKGGHKVTGKL---LGH 294

Human   392 LLGAYVSDVLS----------AAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQLAQEIKNLSGWM 446
            |...||..:.|          .|..:.:::|        ||....:....|.   :|:|      
Zfish   295 LAKIYVDTISSGKVPCLDNAVVALANLENKC--------AVEEAFKVYERGM---EEVK------ 342

Human   447 GRTGPGFTSPDEMAAQ---LHDLRKVEAAKREF----EEYVRQ---------------QDVATKR 489
             :|.|  .:.||::::   ...|...|..||.|    :||:.|               ..:|:|:
Zfish   343 -KTFP--VNVDEISSEHQRFSSLANAEFMKRSFKDEKQEYINQLKEKIDVYYGCLLEDNGLASKK 404

Human   490 IFSALRVLPDTMRNLLSTQKDAILAR-HGVALLCKGRDQTLEALEAE 535
            ....|  |.|....:....:|.:.:: .|..|.||.||..:|....|
Zfish   405 KCEDL--LKDLFSEMNKKLQDGVYSQPGGYELYCKDRDVIVEKYRRE 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNF112XP_006721634.1 RING 56..101 CDD:238093
GBP 163..402 CDD:206650 64/307 (21%)
gbp1NP_001002343.1 P-loop_NTPase 18..281 CDD:328724 61/298 (20%)
GBP_C 283..579 CDD:308475 41/192 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2037
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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