DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF112 and atl

DIOPT Version :9

Sequence 1:	XP_006721634.1	Gene:	RNF112 / 7732	HGNCID:	12968	Length:	639	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	151/547 - (27%)
Similarity:	216/547 - (39%)	Gaps:	125/547 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   142 INAS--GGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGEGGRP 204
            ||||  ...:|...|::..|.....:|..||:::|.|....||||||:..|:.:...........
  Fly     9 INASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73

Human   205 -RGGEAS-LQGCRW--GANGLARGIWMWSHPFLLG-KEGKKVAVFLVDTGDAMSPELSRETRIKL 264
             .|||:. |:|..|  |:.....||.|||..||.. ..|.|:|:.|:||..|...:.:......:
  Fly    74 WLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRDCATV 138

Human   265 CALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQG 329
            .||:|||||.||.:.||.:::.||.:|::|.....:.....|..|.|.|..||||.|.|.:|..|
  Fly   139 FALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYEAEYG 203

Human   330 HV-GNIFQSTPLAASQRLSGRYPKVQELLQG-----KRARCCLLPAPGRRRMNQGHASP------ 382
            .: |:......|..|.:   ::|::|.|.:.     ....|.|:|.||   :|.. .:|
  Fly   204 ALGGDKILKRRLEVSDK---QHPELQSLRRHISSCFTEVACFLMPHPG---LNVA-TNPKFDGRL 261

Human   383 GDTDDDFRHLLGAYVSDVLSAAP----------QHAKSR-----CQGYWN----------EGRAV 422
            .|...:|:..|.:.|..:|  ||          |..::|     .|.|.|          :...|
  Fly   262 QDITPEFKSSLRSLVPMLL--APDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLV 324

Human   423 ARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAA--QLHDLRKVE------AAKR----- 474
            |..:...||....|:|   |.|.:.....|.|.|....|  |...||..:      ||||
  Fly   325 ATAEANHLTAVAAAKE---LYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGE 386

Human   475 EFEEYVRQQ------DVAT--------KRIFSALR---------VLPDTMRNL-----LSTQKDA 511
            ||.|..|:|      :|.|        |.||.|.|         |:...:..:     |.|..:.
  Fly   387 EFTEKFRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANF 451

Human   512 ILARHGVALLCKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVG--AGLM------G 568
            .....|||||      || ||.|.:             |:.|.|:..||.:.  |.|:      .
  Fly   452 CNLVMGVALL------TL-ALWAYI-------------RYSGELSDFGGKLDDFATLLWEKFMRP 496

Human   569 LAGGVVGAGMAAAALAAEAGMVAAGAA 595
            :..|.:..|:...|..|....|..|||
  Fly   497 IYHGCMEKGIHHVATHATEMAVGGGAA 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093
RNF112	XP_006721634.1	GBP	163..402	CDD:206650	77/255 (30%)
atl	NP_001287506.1	GBP	14..289	CDD:280433	83/283 (29%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	44/177 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840