DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF112 and atl2

DIOPT Version :9

Sequence 1:	XP_006721634.1	Gene:	RNF112 / 7732	HGNCID:	12968	Length:	639	Species:	Homo sapiens
Sequence 2:	NP_001103492.1	Gene:	atl2 / 323665	ZFINID:	ZDB-GENE-030131-6505	Length:	599	Species:	Danio rerio

Alignment Length:	524	Identity:	130/524 - (24%)
Similarity:	202/524 - (38%)	Gaps:	92/524 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   127 QETCPVRAEPLLLVRINASGGLI-LRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLL 190
            ::..|..|.|:.:|..|.:.... |...|:.:.|.....:|..|.:::|.|....||||||:.:|
Zfish    67 EDPVPEGARPIQIVITNENDHKFELDAAALEKILLQEHVKDLNVVVVSVAGAFRKGKSFLLDFML 131

Human   191 QGL--PGLESGEGGRPRGGEASLQGCRW--GANGLARGIWMWSHPFLL-GKEGKKVAVFLVDTGD 250
            :.:  ...||..|    |.:..|.|..|  |......||..||..|:: .|:|.||||.||||..
Zfish   132 RYMHDQSAESWIG----GDDEPLTGFSWRGGCERETTGIQAWSEVFVVEKKDGTKVAVLLVDTQG 192

Human   251 AMSPELSRETRIKLC----ALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQ 311
            |    ...::.||.|    ||:||.||.|:.:.||.:::.||.:|::|.....:..:.....|.|
Zfish   193 A----FDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYEKPFQ 253

Human   312 HLDLLVRDSSHPNKAGQG-HVGNIFQSTPLAASQRLSGRYPKVQELLQGKRAR---------CCL 366
            .|..|:||..:|.:...| ..||.|....|...|       ...|.||..|..         |.|
Zfish   254 KLLFLIRDWCYPYEHDYGLKGGNSFLERRLQVKQ-------NQHEELQNVRKHIHSCFSSIGCFL 311

Human   367 LPAPGRRRMNQGH--ASPGDTDDDFRHLLGAYVSDVLSAAPQH--------AKSRCQGYWNEGRA 421
            ||.||.:.....|  ......||:|:..|...|.  |..||::        ||..|:......:|
Zfish   312 LPHPGLKVATNPHFDGRLRGIDDEFKRELQNLVP--LLLAPENLVEKEIGGAKVTCRDLVEYFKA 374

Human   422 VARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVA 486
            ..    ::..|::|               |...|..:..|:.::|..|..||..:...:.|....
Zfish   375 YI----KIYQGEEL---------------PHPKSMLQATAEANNLTAVAGAKDTYNRTMEQVCGG 420

Human   487 TKRIFSA--LRVLPDTMRNLLSTQKDAILARHGVALLCKGRDQTLEALEAELQATAKAFMDS--- 546
            .|...:.  |:...|..:.....|...:....||....:.::|    ||.||......|:..
Zfish   421 NKPYIAPVDLQRYHDEFKKTSVDQFRGVKKMGGVEFCHRYQEQ----LETELDEVYTNFVKHNES 481

Human   547 -------------YTMRFCGHL-AAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAG--AA 595
                         :.:.|..:: :.|.|.:|...:.....|| .|:...:|.|.:.:..:|  ..
Zfish   482 KNIFYAARTPATLFAVMFVTYMVSTVTGFIGLSFIAALASVV-MGVTLLSLCAWSYVRYSGEYRE 545

Human   596 VGAT 599
            ||.|
Zfish   546 VGVT 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093
RNF112	XP_006721634.1	GBP	163..402	CDD:206650	80/259 (31%)
atl2	NP_001103492.1	P-loop_NTPase	86..357	CDD:304359	86/287 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810