DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNF112 and atln-2

DIOPT Version :9

Sequence 1:	XP_006721634.1	Gene:	RNF112 / 7732	HGNCID:	12968	Length:	639	Species:	Homo sapiens
Sequence 2:	NP_502809.2	Gene:	atln-2 / 189829	WormBaseID:	WBGene00012763	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	130/515 - (25%)
Similarity:	207/515 - (40%)	Gaps:	95/515 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   120 RPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSF 184
            ||    :|...|...:|         |...|...|:|..|.|....:..:.:::|.|....||||
Worm    28 RP----VQIIAPSSTQP---------GKFRLNESALNSVLGHSACANKKIVIISVAGAFRKGKSF 79

Human   185 LLNHLLQGLPGLESGEGGRPR----GGEASLQGCRWGANGLAR---GIWMWSHPFLL-GKEGKKV 241
            |||..|:.|..|...:.....    ..:..|.|..|.| |:.|   |||:|..|.:: ...|:..
Worm    80 LLNFFLEYLYSLHKSQQSDSSLEWLTDDCQLHGFHWRA-GVKRDTVGIWLWGEPIMIESVTGEMF 143

Human   242 AVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFV---HVAEVMGK 303
            ||.|:||........:.:..:.:.||:|::||.||.:....:::..|.:|.:||   .:|.....
Worm   144 AVVLMDTQGTFDNNSTYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEYGRIAMEQPH 208

Human   304 HYGMVPIQHLDLLVRDSSHPNK------AGQGHVGNIFQSTPLAASQRLSGRYPKVQELLQG--K 360
            ::|. |.|.|...|||..:..:      .|...:.|:.|:.|....:     ..:|:|||:.  :
Worm   209 NFGK-PFQQLVFCVRDFKNQEEYEFGENGGTDFLDNVLQTNPEQPEE-----IKQVRELLREYFE 267

Human   361 RARCCLLPAPG----RRRMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRA 421
            ..:|.|||.||    .|:..:||..  |....||..|...|.::|  .|...|.:
Worm   268 DIQCYLLPHPGYKVAERQSFRGHVK--DLRPLFREELKKMVPNLL--GPHILKPK---------- 318

Human   422 VARGDRRLLTGQQLAQEIKN-LSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDV 485
            :..|  :.:|.:::.|..|. .:.:.|.|.|   .|..:......|..:|||......|.|..|.
Worm   319 IVNG--KTVTCRKMIQYFKEYAASFDGETLP---QPQSILNANAKLICIEAAHEAKVNYSRGMDR 378

Human   486 AT--KRIFSALRVLPDTMRNLLSTQKDAILARHGVALL-----CK--GRDQTLEALEAELQATAK 541
            :|  .|:.|..::|...:             :||:..|     |.  |..:....|..:||....
Worm   379 STYGTRMMSEKKLLEAHI-------------KHGITALNIFDKCPRIGAKEVRNLLLEKLQEDIN 430

Human   542 AFMDSY-----TMRFCG---HLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAG 593
            |.::.|     ..|..|   .:.|.|.:|..|: ||.....|| :|.|.|..:||:|:.|
Worm   431 AELEKYKRLNEAKRVTGCASAMLACGDSVFLGI-GLGSAASGA-IAGAVLTLQAGVVSLG 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093
RNF112	XP_006721634.1	GBP	163..402	CDD:206650	70/261 (27%)
atln-2	NP_502809.2	P-loop_NTPase	41..310	CDD:393306	76/277 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910