Protein Alignment RNF112 and rnf112.6

DIOPT Version :10

• Sequence 1: XP_006721634.1
• Gene: RNF112 / 7732
• HGNCID: 12968
• Length: 639
• Species: Homo sapiens
• Sequence 2: XP_017953046.2
• Gene: rnf112.6 / 105948498
• XenbaseID: XB-GENE-29090059
• Length: 560
• Species: Xenopus tropicalis
• Alignment Length: 585
• Identity: 173/585 - (29%)
• Similarity: 272/585 - (46%)
• Gaps: 93/585 - (15%)

Human    57 CSICLERLRDPISLDCGHDFCIRC---FSTHRLPGCEPPCCPECRKICKQKRGLRSLGEKMKLLP 118
            |.:||.|....:::.|||.||..|   :.|.|.|  :...||:|||
 Frog    17 CPLCLRRPIRALTIPCGHTFCGTCIDPYRTSRNP--QLYNCPKCRK------------------- 60

Human   119 QRPLPPALQETCPVRAEPLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKS 183
                     ||   ||.|:.||..:.||.|.:...|:..|...|...|.||||:..:||:..|||
 Frog    61 ---------ET---RARPIELVYTDESGKLWVDGSAVQTCFMDPELSDLPVCLIFAIGEKRWGKS 113

Human   184 FLLNHLLQGLPGLESGE------GGRPRGGEASLQGCRW--GANGLARGIWMWSHPFLLGKEGKK 240
            ||:|::|:.|...|.||      .|.|      |.|..|  |.:.:.:|||:|:.||:|.....|
 Frog   114 FLMNYILRALSCQERGEPLSLGPDGEP------LNGFEWKAGVDSVTKGIWIWNKPFVLEVMSGK 172

Human   241 VAVFLVDTGDAMSPELSRETRIKLCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHY 305
            :|||::||..::..:.|:|..|||.||:.:||||.|.:.:..||.|:|:|||||:|||:.....:
 Frog   173 MAVFVLDTEGSLDIQSSQEICIKLSALSMILSSYLIFNVNSSLKTTELNYLEMFLHVAKKTEMSF 237

Human   306 GMVPIQHLDLLVRDSSHPNKAGQGHVGNIFQSTPLAASQRLSG--RYPKVQELLQGKRARCCLLP 368
            .::.:||||:|:||..:.....:....:.|..    ..|.:..  .:..:.:.|......|.|||
 Frog   238 DLLYLQHLDILIRDWYNFGGCSRDDARDYFNK----VKQDIDNHPEWASLHQALHSSMVTCSLLP 298

Human   369 APGRR--RMNQGHASPGDTDDDFRHLLGAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRRLLT 431
            .|..:  |..||..|  |.|:.||:.|..|:||::....:|.|:...|             :.::
 Frog   299 RPDNKMLRSRQGRLS--DMDECFRNNLTTYISDLVGNIWRHIKTTRNG-------------QPVS 348

Human   432 GQQLAQEIKNLSGWMGRTGPGFTSPDEMAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRV 496
            ..:||..:|.:...:......|.||.::.....:.:.::..|.:|:..::..:   .:.||.:::
 Frog   349 CHRLAGILKQMVDILQNEEYSFASPMQLHYSFENYKAMQQCKEQFQNALKAME---PKSFSPIKI 410

Human   497 L---PDTMRNLLSTQKDAILARHGVALLCKGRD-----QTLEALEAELQATAKAFMDSYTMRFCG 553
            |   |..|...:..:.:|:|...|.:|  :|.|     :.|..|:::|......|...|:..
 Frog   411 LKMSPSDMEAKVRNEANAMLRECGKSL--QGIDDEKKRRHLADLQSQLDLQQNLFCTKYSKI--- 470

Human   554 HLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAV-GATGAAVVGGGVGAGLAATVG 617
            |.|...|.:..|.|....|||..|.|.||:   ||.|.||..| ||.|.:|:.|.:|.||.:..|
 Frog   471 HTAVKTGCIVGGTMLSVAGVVAGGAAGAAV---AGAVIAGETVGGAMGGSVLLGTIGTGLGSIGG 532

Human   618  617
             Frog   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING-HC_RNF112	53..104	CDD:438200	18/49 (37%)
		GBP	163..402	CDD:206650	88/250 (35%)
rnf112.6	XP_017953046.2	RING_Ubox	12..66	CDD:473075	22/81 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	95..333	CDD:476819	88/249 (35%)