Protein Alignment RNF112 and rnf112.1

DIOPT Version :9

• Sequence 1: XP_006721634.1
• Gene: RNF112 / 7732
• HGNCID: 12968
• Length: 639
• Species: Homo sapiens
• Sequence 2: XP_031749012.1
• Gene: rnf112.1 / 100492292
• XenbaseID: XB-GENE-5960850
• Length: 621
• Species: Xenopus tropicalis
• Alignment Length: 645
• Identity: 213/645 - (33%)
• Similarity: 323/645 - (50%)
• Gaps: 66/645 - (10%)

Human    15 LGKRERKQSFMGNSGNSWSHTPFPKLELGLGPQPMAPRELPTCSICLERLRDPISLDCGHDFCIR 79
            :|....||..|...|.:    .|.|||           |..|||:||..|.||:|:.|||.||..
 Frog     1 MGGSSSKQPSMPREGAA----SFHKLE-----------EDITCSVCLSELTDPVSITCGHTFCRN 50

Human    80 C----FSTHRLPGCEPPCCPECRKICKQKR-----GLRSLGEKMKLLPQRPLPPALQETCPVRAE 135
            |    ::|.::.|..   ||||||:|.:.:     .|::|...::|:.:.  ..|.:||.|. |.
 Frog    51 CIVSYWATPQIWGYR---CPECRKVCPRDQLIPVHRLKNLVTNVQLVVRE--EQAKKETPPC-AI 109

Human   136 PLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGE 200
            |  ||..::.|.|.....|:..|.......:.||.|:.::||:..|||||||::|:.|...|..|
 Frog   110 P--LVYTDSRGQLQTDEAAVQSCFLSSDVSNCPVVLICMIGEKRRGKSFLLNYILRALSCQERDE 172

Human   201 GGRPRGGEASLQGCRW--GANGLARGIWMWSHPFLLGKEGKKVAVFLVDTGDAMSPELSRETRIK 263
            .....|.:..|.|..|  |...:.:|||:|:.||:|.:.|:|:|||::||..::..|.||:..||
 Frog   173 PISLGGEDEPLSGFEWRAGTESITKGIWIWNKPFVLERNGEKMAVFVLDTEGSLDIESSRDISIK 237

Human   264 LCALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQ 328
            |.||:.:||||.|.:.:..||.|:||||||:::|||:.||.:.:..:||||:|:||........:
 Frog   238 LSALSMILSSYLIFNVNSSLKTTELDYLEMYLYVAELAGKSFDLQYLQHLDILIRDWHDSLNCQR 302

Human   329 GHVGNIFQSTPLAASQRLSGRYPKVQELLQGKRARCCLLPAPGRRRMNQGHASPGDTDDDFRHLL 393
            |...:.....  ..:.|.:.|||.|.:.|:.....|||||.||:|.:.....|..|.|:||::.|
 Frog   303 GDAQSYINRE--TENLRKASRYPFVLDTLRSPSVGCCLLPHPGKRLLGDSQGSLSDMDEDFKNHL 365

Human   394 GAYVSDVLSAAPQHAKSRCQGYWNEGRAVARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDE 458
            |.|::|::           :|.|...:....|::  :|..||..::|...|.:.:....|.||.|
 Frog   366 GNYITDLV-----------RGIWRHVKTDIHGEK--VTCAQLEGKLKEFVGLLQKEQYSFASPLE 417

Human   459 MAAQLHDLRKVEAAKREFEEYVRQQDVATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALL-- 521
            |.....:.:.:.:.||||..::.....|:...|..|.|.|..|:...|......||.:..::.
 Frog   418 MFFTFENRKNMSSVKREFLNHLDNLAPASSSPFKILGVTPSKMKGRTSEAAAHFLAVYEESIKGD 482

Human   522 -CKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAA 585
             .:||...:|.:|:.|:.....|.|.|:.||......:|.|:|.|::.||||||||.:|...|||
 Frog   483 DSQGRQLLMEEMESILREAEDKFNDEYSKRFKKCAIGIGCAIGGGVLSLAGGVVGAAVAGTVLAA 547

Human   586 EA----GMVAAGAAVGATGAAV--------VGGGVGAGLAATVGCMEKEEDERLLE--GD 631
            ||    |...|....||.|..|        ||.|||||:...:...:.|.:::..|  ||
 Frog   548 EAVALVGSTTAAVITGAVGGTVTLGAIGTGVGAGVGAGVGGAIANRKTEAEQQTTEEGGD 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF112	XP_006721634.1	RING	56..101	CDD:238093	23/48 (48%)
		GBP	163..402	CDD:206650	93/240 (39%)
rnf112.1	XP_031749012.1	RING_Ubox	25..70	CDD:418438	20/47 (43%)
		P-loop_NTPase	140..374	CDD:422963	93/246 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I30490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5176
Inparanoid	1	1.050	312	1.000	Inparanoid score	I10424
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39698
OrthoDB	1	1.010	-	-		D187713at32523
OrthoFinder	1	1.000	-	-		FOG0006675
OrthoInspector	1	1.000	-	-		otm55209
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11885
SonicParanoid	1	1.000	-	-		X3792
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110