Protein Alignment CACNA1A and cacna1aa

DIOPT Version :10

• Sequence 1: NP_075461.2
• Gene: CACNA1A / 773
• HGNCID: 1388
• Length: 2512
• Species: Homo sapiens
• Sequence 2: NP_001429978.1
• Gene: cacna1aa / 562059
• ZFINID: ZDB-GENE-040724-26
• Length: 2483
• Species: Danio rerio
• Alignment Length: 2577
• Identity: 1793/2577 - (69%)
• Similarity: 1984/2577 - (76%)
• Gaps: 282/2577 - (10%)

Human     1 MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQPGA-QRMYKQSMAQRARTMALYNP 64
            |||||||:|:|||||...|.        ||.|.|||||||.||| ||||||||||||||||||||
Zfish   124 MARFGDEVPSRYGGGPGHAQ--------GGPGRGGSRQGGPPGAQQRMYKQSMAQRARTMALYNP 180

Human    65 IPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129
            |||||||.|||||||:|||||.|||||||||||||||||||||||||||||||||||||.|||||
Zfish   181 IPVRQNCFTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPM 245

Human   130 SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTL 194
            ||||:|||||||||||||:||||:|||||||||||||||||||||||||||||:|||::||||||
Zfish   246 SERLEDTEPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDFDLRTL 310

Human   195 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEE 259
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||::
Zfish   311 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDK 375

Human   260 GTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLL 324
            .||:|:.|  .|||.|.|||.|||||.|:.||.|||.||||||||||||||||||||||||||||
Zfish   376 ITDEIREE--FPCGEEVPARICPNGTVCKKYWLGPNYGITQFDNILFAVLTVFQCITMEGWTDLL 438

Human   325 YNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIEREL 389
            |.||||:|:.|||:|||||||||||||||||||||||||||||||||||..||||:|||||||||
Zfish   439 YYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIEREL 503

Human   390 NGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFA 454
            |||:|||.||||||||:::.|.:.|.||||:.||.||||||||||:.|:.:      ..:|||||
Zfish   504 NGYLEWICKAEEVILADEDNDPDDRMPFDGSRRRPTIKKSKTDLLDAEDGD------GDIGSPFA 562

Human   455 RASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFL 519
            |.|:||:|||.|: |||||||:||:|||:|||||||||||.||.|||||||:|||:|||.|||||
Zfish   563 RGSLKSSKLEGSS-FHKKERRLRFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVHYDQPETLSDFL 626

Human   520 YYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRA 584
            |:|||||||:|||||.|||||||||||||||||||||.||.||||||:||:|:||||||||||||
Zfish   627 YFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGTSFGISVLRA 691

Human   585 LRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPT 649
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:.|||||
Zfish   692 LRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEAGTPPT 756

Human   650 NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAV 714
            ||||||||||||||||||||||.||||||:|||||:.|||||::|||||||||||||||||||||
Zfish   757 NFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLAIAV 821

Human   715 DNLANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAV--------------- 764
            |||||||||||   ||||||:|||:|:|||.||||||||||||||:|||.
Zfish   822 DNLANAQELTK---DEQEEEQAANKKMALQTAKEVAEVSPLSAANLSIAASCQPHNHKGQNVTVN 883

Human   765 -------------KEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLR 816
                         ||||||.|..||||||||||:|:|.|:.||||||||:||::|||.:|:||:|
Zfish   884 SERLDATEHFLDCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALYNELDPEDRWKVSYSRHIR 948

Human   817 PDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQ-QRAEDFLRKQARYHDRARDPSGSAG 880
            |||||||||||||||||||||||||:|..:       || |.:...|.||..:::  .:..|..|
Zfish   949 PDMKTHLDRPLVVDPQENRNNNTNKTRPGD-------GQPQHSHQLLHKQPNFNE--AETGGGGG 1004

Human   881 LDARRPWAGSQEAEL--SREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQ--G 941
            .::   |...:..:.  ||....|.|   |..||.                 :.||||.|.|  .
Zfish  1005 SES---WPALERGDSTGSRRSLLGSE---HYEEGR-----------------ESHRRHQHSQHCS 1046

Human   942 GSRESRSGSPRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERR 1006
            .:|:.|..:...|..| .||||:..:  |.||                      |.|..|||||:
Zfish  1047 QARQHRKAAEGGGEPG-GRRHRSKAK--ERGP----------------------ECEHSDGGERK 1086

Human  1007 -RRHRHGAPATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDID 1070
             |||||      ||:.|:| :..|||.|::..     .|||.||||||||:.|.|||...:||:|
Zfish  1087 HRRHRH------EGEGRKE-RGVRHRNRRDGH-----ASGPTLSTTRPIQKTLSRQDSQYSEDLD 1139

Human  1071 NMKNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNP 1135
            |..||||||    .||.||                            .|..|.|......:.|.
Zfish  1140 NAMNNKLAT----QPHDSL----------------------------LNLANTAHSAGLAHTGT- 1171

Human  1136 SNPGPPKTPENSLIVTNPSGTQTNSAKTAR---KPDHTTVDIPPACPPPLNHTVVQVNKNANPDP 1197
                     |:|||:||||.|..|......   ||::|.|||||..|.  ::.::|||||||.:|
Zfish  1172 ---------ESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPS--SNAILQVNKNANTEP 1225

Human  1198 LPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSI 1262
            |||||:.|.::::|::.:.||||||||:|||||:||||.|||||||:.|||||||||:|||||||
Zfish  1226 LPKKEDTKGDDDDDEKDDGGPKPMPPYTSMFILTTTNPFRRLCHYIVTLRYFEMCILLVIAMSSI 1290

Human  1263 ALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGA 1327
            ||||||||.|.:|||||||||||||||||||||:|||:|||||||||:|||||||||||||||||
Zfish  1291 ALAAEDPVWPESPRNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGA 1355

Human  1328 LVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMF 1392
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||.|||||||||||
Zfish  1356 LVAFAFTGNSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMF 1420

Human  1393 IFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEK-NEVKARDREWKKYEFHYDNVLWALLTL 1456
            ||||||||||||:||:|||||||||:||||:||:||: |||:::.||||||:|||||||||||||
Zfish  1421 IFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYERDNEVRSQKREWKKYDFHYDNVLWALLTL 1485

Human  1457 FTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQG 1521
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Zfish  1486 FTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQG 1550

Human  1522 DKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVL 1586
            |||||:|||||||||||||||:|||||||||||||:||||||:|||||||||||||:||||||||
Zfish  1551 DKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQTFQYRMWEFVVSPPFEYTIMALIALNTIVL 1615

Human  1587 MMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVT 1651
            |||:.|||:.||:.|:..|||||||||:||:||::|||.||||:|||||||.|||||||||||||
Zfish  1616 MMKYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFDCVTVLGSITDILVT 1680

Human  1652 EFGNPNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1716
            |.|  ||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Zfish  1681 ELG--NNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1743

Human  1717 QVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSG 1781
            |:||||.|   :|:||.   .||:||||||||||||||||||||||||:||||||..||||..|.
Zfish  1744 QLFGNIKI---EENSDS---AITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKKPCDILSD 1802

Human  1782 ILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDP 1846
            .|..|||:||||.|||||||||||||||||||||||||||||||||||||||||||||:||||||
Zfish  1803 NLKPECGSEFAYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDP 1867

Human  1847 AAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALD 1911
            ||.||:.|.|||.:||.:.||||||||||.|||.|||||||||||||||||||||||||||||||
Zfish  1868 AACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALD 1932

Human  1912 IKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKS-TDLTVGKIYAAMMIMEYYRQSK 1975
            |||||||.||.||||||||||||||||||||.|||||||||| ||||||||||||||||||||||
Zfish  1933 IKIAKGGVDKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSK 1997

Human  1976 AKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSWVTQR 2040
            ||:.||:.:||:||||||||:|||||:|:.|||...||.||:.|...|...|. :.||.||||.|
Zfish  1998 AKRTQALHDEQNRTPLMFQRLEPPSPSQDVGPGLTGLPDTQMHPANHLPVDER-IPESQSWVTAR 2061

Human  2041 AQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAASMPRLPAE 2105
            |||:.||.|.||||...|.|..:::..||:|||||||||||||:|.||||||.|||||||||||:
Zfish  2062 AQEISQKAGNWSPEGQHPDDTTDNRRQSQTVEMREMGRDGYSDTEQYLPMEGHGRAASMPRLPAD 2126

Human  2106 NQRRRGRPRGNNLSTISDTSPMKRSASVLG----PKARRLDDYSLERVPPEENQRHHQRRRDRSH 2166
            ||:           .|:|.||||||||.||    .::.|.:||::|||.|||..||..|.|||||
Zfish  2127 NQQ-----------PITDNSPMKRSASSLGHGRAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSH 2180

Human  2167 RASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRKHRQHHHHHHHHHHPPPPDK 2231
            |||||||.||||.|||||||||.|||||||||||||  |||.||||    ||||||||| ...||
Zfish  2181 RASERSLSRYTDADTGLGTDLSTTTQSGDLPSKERD--RGRAKDRK----HHHHHHHHH-GSLDK 2238

Human  2232 DRYAQERP----DHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQL 2292
            :.|..||.    .|.::|.||:|||||||||||.:.||||||||||||.||||||||||||||||
Zfish  2239 EHYGHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQL 2303

Human  2293 PQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAG 2357
            ||||:||||||:||||:||...|.||..||              .|..|...||: .||     |
Zfish  2304 PQTPATPRPHVTYSPVVRKPISSTPPPGQQ--------------SRLPTPTSRRF-SPT-----G 2348

Human  2358 DRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYD 2422
            ..||...|..          |.|....|||:.||  |.|   ||..:|...|   .|:|...||:
Zfish  2349 PEPPLPPHHH----------PSPPHHGSPRSGRH--AHW---GPEPAESVEG---DGFYDDQDYE 2395

Human  2423 EADGPGSGGGEEAMAGAYDAPPPVRHASSGATG----RSPRTPRASGPACASPSRHGRRLPNGY- 2482
                             ::...|..:..|...|    .||||.|.:.|  .....|.||:||||
Zfish  2396 -----------------FNHHEPPSYEQSPVQGNPHPHSPRTSRHNTP--PQGQAHPRRMPNGYR 2441

Human  2483 ---------YPAH-GLARPRGP-GSRKGLHEPYSESD-DDWC 2512
                     .||| |..:|..| |.||||||||||:| ||||
Zfish  2442 SSSPSPHHHAPAHPGTHKPPHPRGPRKGLHEPYSETDEDDWC 2483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1A	NP_075461.2	I	85..363		246/277 (89%)
		Ion_trans	97..371	CDD:459842	243/273 (89%)
		Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:P27884	383..400		14/16 (88%)
		II	473..717		219/243 (90%)
		Ion_trans	487..725	CDD:459842	216/237 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1224		147/410 (36%)
		III	1234..1517		258/283 (91%)
		Ion_trans	1247..1478	CDD:459842	210/231 (91%)
		Ion_trans	1568..1827	CDD:459842	213/258 (83%)
		GPHH	1836..1889	CDD:465306	40/52 (77%)
		Ca_chan_IQ	1899..1976	CDD:462591	73/77 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1994..2037		21/42 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2049..2512		252/487 (52%)
		PHA03307	2239..>2509	CDD:223039	125/290 (43%)
		polyglutamine repeat	2319..2331		2/11 (18%)
cacna1aa	NP_001429978.1	None