Protein Alignment CACNA1A and cac

DIOPT Version :10

• Sequence 1: NP_075461.2
• Gene: CACNA1A / 773
• HGNCID: 1388
• Length: 2512
• Species: Homo sapiens
• Sequence 2: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Alignment Length: 2584
• Identity: 1086/2584 - (42%)
• Similarity: 1353/2584 - (52%)
• Gaps: 749/2584 - (28%)

Human    77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFI 141
            |||:.:|||.:|||.:.|.|||||||.:|.||||||:|||||:|||..|||.::::|:.||.||:
  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81

Human   142 GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILA---TVGTEFDLRTLRAVRVLRPL 203
            .|||.||.:||:|||...||.|||||.||:|||.||:||.:.   .:|.|.|||||||:||||||
  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146

Human   204 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE-EGTDDI--Q 265
            ||||||||||||||||:|||.||||||||:.|||:||||||||||.|..|.||:. |..:.:  :
  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211

Human   266 GESPAPCGTE---EPAR---TCPNGTK-CQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 323
            |||..||.|:   |.|.   .|.|.|. |...|||||:|||.||||.||:|||||||||||||.:
  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276

Human   324 LYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
            ||.:|||.|:.:||:||:|||:|||||||||||||||||||||||:||||:.|||||||||:|||
  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341

Human   389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK--------KSKTDLLNPEEAEDQLAD 445
            ||||:|||.|||||||||:.|..|::.....|.||...|        |||:.....||||:...|
  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD 406

Human   446 IASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYN 510
            ...:       ..:|....:.|.|.:.|:|.||:||..||||.|||.|:.||.|||:|||:.||.
  Fly   407 DGYL-------KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464

Human   511 QPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGT 575
            ||.:|::||||||||||||||||||||||.||.|.||.||||.|||.||.||||||||:.:| |.
  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528

Human   576 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640
            |||:||||||||||||||||||:||||||:||||||:|||||||||||||::|||||||||||||
  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593

Human   641 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTL 705
            |...|||.|||:|||.|::||||||||||||||||.||.||||.|.||::|||||||.|||||||
  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658

Human   706 LNVFLAIAVDNLANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKN 770
            |||||||||||||||||||..|.::.||::
  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQVEEDK----------------------------------- 688

Human   771 QKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENR 835
                    |::..|:.|:     .|||.
  Fly   689 --------EKQLQELEKE-----MEALQ------------------------------------- 703

Human   836 NNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGP 900
                                                                             
  Fly   704 ----------------------------------------------------------------- 703

Human   901 YGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAH 965
                                                                  |||.|
  Fly   704 ------------------------------------------------------ADGVH------ 708

Human   966 RRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRH 1030
                                    ...|:|
  Fly   709 ------------------------VENGDG----------------------------------- 714

Human  1031 RRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLP 1095
                                                               :.||..|.|
  Fly   715 ---------------------------------------------------AVAPSKSKG----- 723

Human  1096 QSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNS 1160
                                                                             
  Fly   724 ----------------------------------------------------------------- 723

Human  1161 AKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYS 1225
                                                  .|||||||||||   ..:|||||.|||
  Fly   724 --------------------------------------KKKEEEKKEEEE---VTEGPKPMLPYS 747

Human  1226 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGV 1290
            ||||||.|||:||..|:::||.||:..|::||:||||||||||||:.|:.||.:|.||||.||||
  Fly   748 SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGV 812

Human  1291 FTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF--TGNSKGKDINTIKSLRVLRV 1353
            ||.||::|::|||::||.|:|.|:.|||:|.:||..|.|:|.|  :|:|.|::::||||||||||
  Fly   813 FTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRV 877

Human  1354 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEK 1418
            |||||||||:|||||||||||||||||.||||||:||.|||:|:.||||.||||:||||||....
  Fly   878 LRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSA 942

Human  1419 DCRGKYLLYEKNEV--KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQG 1481
            :|:|.|..||::|:  |...|.||...||||||..|:||||.|.|||||||||:||:.||:|::|
  Fly   943 ECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRG 1007

Human  1482 PSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKP 1546
            |...:|:||||||:|||:||||||||||||||||||||||:..:::..::||:::||||.|.|:|
  Fly  1008 PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARP 1072

Human  1547 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1611
            |.|:||:|:.:|:|::|:.|||.||||.||.:|..||::||||::.....||.:|:..|:.||.:
  Fly  1073 LERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGM 1137

Human  1612 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKL 1676
            ||:|.|||::.||:.|:|:|.|||||.:||||||.|.|..|||  :|.||:.|||||||||||||
  Fly  1138 FSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG--SNSINVGFLRLFRAARLIKL 1200

Human  1677 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEH 1741
            ||||||||||||||||||||||||||||||||||||||||||||||.:...       |..||.|
  Fly  1201 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV-------ENSITRH 1258

Human  1742 NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE-CGNEFAYFYFVSFIFLCSF 1805
            |||::|.|.:|||||.||||||.||||:||.||.||.::.....| ||:..||.|||||||.|||
  Fly  1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSF 1323

Human  1806 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGL 1870
            ||||||||||||||:||||||||||.|||||:||:||||||.|.|::.|.:||.||::|.||||.
  Fly  1324 LMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGF 1388

Human  1871 GKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAI 1935
            |.|||.|:|||:|:||::|:.|:..|.|.:||.||||..|.||: :...:..|.|.|||:.:..|
  Fly  1389 GNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNI 1452

Human  1936 WPNLSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKKLQA---MREEQDRTPLMFQ 1994
            ||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|.:   |.|.||.:
  Fly  1453 WPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDAS----- 1512

Human  1995 RMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSW----------------------- 2036
                ..|:||...|.:|   ..|.||.:.|   :|.:.|||.
  Fly  1513 ----RHPSQESLTGADA---GHLHPGHSYM---NGHRRSPSLRHNGSPLARSPSPRRRGHQYIHH 1567

Human  2037 ------VTQRAQEMFQKT--------------GTWSPEQGPP-----------------TDMP-- 2062
                  ......||.::|              |:||....|.                 |.:|
  Fly  1568 DIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYP 1632

Human  2063 -----------NSQPNSQSVEMREMGRDGY------SDSEHYLPMEGQGRAA---SMPRLPAENQ 2107
                       .|...::..||||..|.||      :..:|..|.....||.   .:|..|::..
  Fly  1633 TYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPS 1697

Human  2108 RRRGRPRGNNLSTISDTSPMKRSASVLG-----PKARRL-----DDY--SLERVPPEENQRHHQR 2160
            ..:.:|...|...: :.||.....|...     |..|.|     |.|  |.||....|..|...|
  Fly  1698 TLQLKPTNINFPKL-NASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDR 1761

Human  2161 RRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-------------------- 2205
            .|||. |..|..| ||...|           :..:|..:|||:||
  Fly  1762 DRDRD-RLHEYDL-RYEYRD-----------RERELYERERDREREVERERLEYIAPLSFEQALA 1813

Human  2206 ----GR-----------PKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSP 2255
                ||           ||...:.:|          ...|::.:..:|........:||.|
  Fly  1814 MGRTGRVLPSPVLNGFKPKSGLNPRH----------SDSDEEDWCXQRLXLRSRNRKDQIW---- 1864

Human  2256 SEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQ 2320
                  :.|:...||:|   ||:........|...|:|:       |:...|.:      .||..
  Fly  1865 ------VXHQAICSSLS---APNLDHNFDTIRHSYQIPE-------HLQNLPYL------CPPVH 1907

Human  2321 QQQQQQQQQQQ----------------AVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGR 2369
            |.|.|.|.|.|                .|:.|....|....:..|.:.:.|          |..|
  Fly  1908 QHQHQHQTQTQNQRQHQDQHLYQRYGTNVSTPKLGTTISDIKLAGVSLQEL----------SPNR 1962

Human  2370 SPRMERRVPGPARSESPRACRHGGARW-PASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGE 2433
            .|:.:::       :..:..:.|..|| ..|||:                             |.
  Fly  1963 QPQSQQK-------QEQQLHQDGWLRWYRQSGPY-----------------------------GS 1991

Human  2434 EAMAGAYD--APPP---------VRHASSGATGRSPRTPRASGPACASP 2471
            ..||...:  |..|         ::.:.:|.|..:|||.:......:.|
  Fly  1992 PVMASLPETRATSPHSDIEFIRTMKRSETGTTAITPRTTKTEAMILSVP 2040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1A	NP_075461.2	I	85..363		189/290 (65%)
		Ion_trans	97..371	CDD:459842	190/286 (66%)
		Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:P27884	383..400		13/16 (81%)
		II	473..717		192/243 (79%)
		Ion_trans	487..725	CDD:459842	191/237 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1224		26/401 (6%)
		III	1234..1517		188/286 (66%)
		Ion_trans	1247..1478	CDD:459842	152/234 (65%)
		Ion_trans	1568..1827	CDD:459842	173/259 (67%)
		GPHH	1836..1889	CDD:465306	32/52 (62%)
		Ca_chan_IQ	1899..1976	CDD:462591	33/79 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1994..2037		13/71 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2049..2512		105/537 (20%)
		PHA03307	2239..>2509	CDD:223039	47/261 (18%)
		polyglutamine repeat	2319..2331		5/11 (45%)
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	190/286 (66%)
		Ion_trans	441..677	CDD:459842	190/236 (81%)
		Ion_trans	769..1050	CDD:459842	187/280 (67%)
		Ion_trans	1094..1345	CDD:459842	173/259 (67%)
		GPHH	1354..1407	CDD:465306	32/52 (62%)
		Ca_chan_IQ	1417..1496	CDD:462591	33/79 (42%)
		AF-4	<1512..>1704	CDD:461550	36/206 (17%)