Protein Alignment CACNA1A and unc-2

DIOPT Version :10

• Sequence 1: NP_075461.2
• Gene: CACNA1A / 773
• HGNCID: 1388
• Length: 2512
• Species: Homo sapiens
• Sequence 2: NP_001355464.1
• Gene: unc-2 / 180570
• WormBaseID: WBGene00006742
• Length: 2171
• Species: Caenorhabditis elegans
• Alignment Length: 2509
• Identity: 1049/2509 - (41%)
• Similarity: 1315/2509 - (52%)
• Gaps: 707/2509 - (28%)

Human    36 SRQGGQPG------AQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKI 94
            |||...|.      |:|..|.......|...|.:..||::...:   |||:|:|||::|:.||.|
 Worm   187 SRQLPSPSQLAAEEARREQKAESGTFVRKTTLSSNAPVKEKGPS---SLFIFAEDNIIRRNAKAI 248

Human    95 TEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
            .||.||||.||.|||.||:||::|||||.:||..:||.|:.|||||:||||.|..:|:||.|||.
 Worm   249 IEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFAL 313

Human   160 HKGSYLRNGWNVMDFVVVLTGILATV----GTE--------FDLRTLRAVRVLRPLKLVSGIPSL 212
            |||||||:|||:|||:||::|::..:    .|:        .|||||||||||||||||||||||
 Worm   314 HKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSL 378

Human   213 QVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF-EEGTDDIQGESPAPCGTEE 276
            |||||||:.||.||||||||:.|||:||||||||||.|.||:.|: |.|..:...|.|.||..
 Worm   379 QVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTN-- 441

Human   277 PARTCP--------NGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 333
              :|.|        .||.|...|.|||.|||.||||.||::||||||||||||.::|.:||:.|:
 Worm   442 --KTSPMGVYNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGS 504

Human   334 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISK 398
            |:||.||||||::||||||||||||||||||||||||||||.|||||||||||||||||:|||..
 Worm   505 TYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILT 569

Human   399 AEEVILAEDETDGEQRHPFDGALRRTTIKKSK-----------TDLLNPEEAEDQLADI-----A 447
            ||||||.||.|..|::.....|.||...||.|           .|.   ||.||::.:.     .
 Worm   570 AEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDF---EEDEDEMEEEYVDEGG 631

Human   448 SVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQP 512
            :|...||....:........|.    :::|..||.|||||.|||:|::||.|||.|||..||.||
 Worm   632 TVEDEFAERKKRGCCHSVGKFI----KQLRIQIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQP 692

Human   513 EWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSF 577
            :|.:|||.||||:|||:|:.||.:|::.:|:|.||.|.||.|||.||:||..|||||.:. |.||
 Worm   693 QWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVY-GGSF 756

Human   578 GISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF 642
            ||||:||||||||||:|.||.||||||.||:|||:|||||||||||||::|||||||||||:|||
 Worm   757 GISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNF 821

Human   643 DEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGV-QGGMVFSIYFIVLTLFGNYTLL 706
            ....|.|:|||||.|::||||||||||||||||..|:||||: .||..:|||||||.||||||||
 Worm   822 PTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLL 886

Human   707 NVFLAIAVDNLANAQELTKV-EADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKN 770
            ||||||||||||||||||.. ||||              ||.|:
 Worm   887 NVFLAIAVDNLANAQELTAAEEADE--------------KANEI--------------------- 916

Human   771 QKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENR 835
                    |:.:.|:.:|         |.|.|           |...||
 Worm   917 --------EEESEELDEQ---------YQEGD-----------HCTIDM---------------- 937

Human   836 NNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGP 900
                                                                             
 Worm   938 ----------------------------------------------------------------- 937

Human   901 YGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAH 965
                                ||:.    |||
 Worm   938 --------------------EGKT----AGD---------------------------------- 944

Human   966 RRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRH 1030
                                                                             
 Worm   945 ----------------------------------------------------------------- 944

Human  1031 RRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLP 1095
                                                                             
 Worm   945 ----------------------------------------------------------------- 944

Human  1096 QSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNS 1160
                          |.|:
 Worm   945 --------------MCAV----------------------------------------------- 948

Human  1161 AKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYS 1225
               ||..|    |:...|                            ||||...|  |||||.|||
 Worm   949 ---ARAMD----DLDEEC----------------------------EEEESPFG--GPKPMVPYS 976

Human  1226 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGV 1290
            |||.||.|||.|.|.|.|:..:||||.::.||.:||::|||||||....|||.||:|.||.||||
 Worm   977 SMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGV 1041

Human  1291 FTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTG--NSKGKDINTIKSLRVLRV 1353
            |..||::|:||.|::||.|:|.||.|||||.|||:.||.||.|.|  .|.||::|||||||||||
 Worm  1042 FACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRV 1106

Human  1354 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEK 1418
            |||||||||:||||||||||||||||||||||||.||.|||||:|||||.||||.|||::::|..
 Worm  1107 LRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFAN 1171

Human  1419 DCRGKYLLY--EKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQG 1481
            .|.|::.:|  :.:..:...|||:...|:|||.:.|:||||.|:||||||.:.::|:|.|||:||
 Worm  1172 TCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQG 1236

Human  1482 PSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKP 1546
            |||.:|:|:::|||::|:||||||||||||||||||||||:..:.|..|:||::.|||||::|:|
 Worm  1237 PSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARP 1301

Human  1547 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1611
            .:..||::|.|.:||:|:.|.||||||.||.||..||::||||:|...:.||..||:||...|::
 Worm  1302 RSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAV 1366

Human  1612 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKL 1676
            |::|.:||::|||:.|||||.||.||||||:|||||.||||||  .:|::|.|||||||||||:|
 Worm  1367 FTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEFG--GHFVSLGFLRLFRAARLIRL 1429

Human  1677 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEH 1741
            |:||||||||||||||||||||||||||.||||||||:||||||||.::...|        |..|
 Worm  1430 LQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATE--------INRH 1486

Human  1742 NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDK-NSGILTRE----CGNEFAYFYFVSFIF 1801
            |||::||.|::||||.||||.|.:||::.:.||.|.: .|..:..|    ||:..:|.||.||:|
 Worm  1487 NNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVF 1551

Human  1802 LCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSP 1866
            |.||||||||||||||||:||||||||||||||||::||||:|||||.||:.|.:||:|||.|:|
 Worm  1552 LSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAP 1616

Human  1867 PLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKE 1931
            |:|.|||||.|:|||.|:||::|||:|.||||.:||.||||.:|.||: :...:..:.|.|||..
 Worm  1617 PVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKM-RPVEEMDEADEELRLT 1680

Human  1932 MMAIWPNLSQKTL-DLLVTPHKS---TDLTVGKIYAAMMIMEYYRQSK----------------- 1975
            :..|||..::|.: ||:|.|:..   ..||||||||.::|:|.||..|
 Worm  1681 LKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGGQGLFGGGLRS 1745

Human  1976 --AKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKE---SPS 2035
              |....|..:....||      :||..|....| |:|    |.......|:.:..|::   :.|
 Worm  1746 LVAAAKAAESQHSSHTP------QPPEETTPIIP-QHA----QQFSAAPTMSAQGSLQQMQGTSS 1799

Human  2036 WVTQRAQEMFQ------KTGTWSPEQGPPTDMPNSQPNSQSVEMREMGR---DGYS--------- 2082
            ...||...:|.      |:|   .:.|..||:.....:.|..:|...||   |.:|
 Worm  1800 GGGQRPYSLFNSFVDTIKSG---KQDGDVTDVQYQSVDQQHEKMNSTGRRLSDMFSKIRRGTSAD 1861

Human  2083 ----DSEHYLPMEGQGRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDD 2143
                .:||.|               |::.|....||..:::..|..||.:|...   |...|.:.
 Worm  1862 HNPHQTEHLL---------------AQDNRSPSSPRYRSMARASPPSPAERYGH---PPRYRTES 1908

Human  2144 YSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRP 2208
                  ||.....:....||...|.:     ||..::         .::|...|...:||:  :.
 Worm  1909 ------PPSSRSEYQMSIRDPIIRRN-----RYNTME---------HSRSSHDPQYHQDQQ--QQ 1951

Human  2209 KDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSP----------SEGREHMA 2263
            :...|:||..|..|.||....:.::|                 ||||          |..||...
 Worm  1952 QQPHHQQHSQHLQHSHHKTYQNHNQY-----------------SRSPIYSDDSSVAESYRREREF 1999

Human  2264 HRQGSS-----SVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPH------VSYSPVIRKAGGSG- 2316
            .|...|     |....|.|      |..|.|| ||...:.|..:      .||:..:..:.|.|
 Worm  2000 RRYQDSTPQDVSEDDDPMP------TAVRARR-LPLISTMPTHYESAYQPSSYNQHLNDSYGLGT 2057

Human  2317 ---------------PPQQQQQQQQQQQQQAVARPGRA--------------------------A 2340
                           |..||||.|.......:..|..:                          .
 Worm  2058 GYQRDYHTSHSHSHHPTSQQQQHQPMYSTSPLISPRSSHSYYTPRSSQYYEIPSPSPDIYPSYRG 2122

Human  2341 TSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPG 2379
            ::.|||||..|. .:|.||       .|.|.|:.:..||
 Worm  2123 SASPRRYPTSTV-VVAPDR-------EGSSARVIQAQPG 2153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CACNA1A	NP_075461.2	I	85..363		184/298 (62%)
		Ion_trans	97..371	CDD:459842	186/294 (63%)
		Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:P27884	383..400		13/16 (81%)
		II	473..717		171/244 (70%)
		Ion_trans	487..725	CDD:459842	172/238 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1224		22/401 (5%)
		III	1234..1517		181/286 (63%)
		Ion_trans	1247..1478	CDD:459842	146/234 (62%)
		Ion_trans	1568..1827	CDD:459842	167/263 (63%)
		GPHH	1836..1889	CDD:465306	34/52 (65%)
		Ca_chan_IQ	1899..1976	CDD:462591	34/99 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1994..2037		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2049..2512		86/410 (21%)
		PHA03307	2239..>2509	CDD:223039	44/204 (22%)
		polyglutamine repeat	2319..2331		5/11 (45%)
unc-2	NP_001355464.1	Ion_trans	254..536	CDD:459842	178/285 (62%)
		Ion_trans	667..904	CDD:459842	171/237 (72%)
		Ion_trans	998..1279	CDD:459842	181/280 (65%)
		Ion_trans	1323..1577	CDD:459842	167/263 (63%)
		GPHH	1586..1639	CDD:465306	34/52 (65%)
		Ca_chan_IQ	1649..1729	CDD:462591	33/80 (41%)