DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRIM25 and PSH1

DIOPT Version :9

Sequence 1:	NP_005073.2	Gene:	TRIM25 / 7706	HGNCID:	12932	Length:	630	Species:	Homo sapiens
Sequence 2:	NP_014587.1	Gene:	PSH1 / 854102	SGDID:	S000005415	Length:	406	Species:	Saccharomyces cerevisiae

Alignment Length:	346	Identity:	81/346 - (23%)
Similarity:	128/346 - (36%)	Gaps:	97/346 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     2 AELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGS--PYLCPQCRAVYQARPQLH 64
            |.|..:.|.|.||||.:....|:.||||||:|..||| ||....:  ...|||||:.....|.|
Yeast    19 AILYKIIESLVCSICHDYMFVPMMTPCGHNYCYGCLN-TWFASNTQKELACPQCRSDITTIPAL- 81

Human    65 KNTVLCNVVEQFL-------------------------QADLAREPPAD-----VWTPPARASA- 98
             ||.|    :|:|                         :.|...:...|     |:...|.|.|
Yeast    82 -NTTL----QQYLSFILEKLRDQNDESFKKLLTTKTKEENDYKNDKEKDTLFDKVFKNSALAVAD 141

Human    99 PSPNAQVACDHC---LKEAAVKTCLVCMASFCQEHLQPH------FDSPAFQDHPLQPPVRDLLR 154
            .|.:....|.:|   |....|:...||  ..|...::.:      ||...:.:..|. .:|:.:|
Yeast   142 DSDDGITRCSNCHWELDPDEVEDGNVC--PHCNARIRNYAGGRDEFDEEEYSEGELD-EIRESMR 203

Human   155 RKCSQHNRLREFFCPEHSECICHICLVEHKTCSP-------ASLSQASADLEATLRHKLTVMYSQ 212
            |:  :.||.                    .:.:|       :|....|::.|....|.....:::
Yeast   204 RR--RENRF--------------------ASTNPFANRDDVSSEDDDSSEEEPMREHIPLGRWAR 246

Human   213 INGASRALDDVRNRQQDVRMTANRKVEQLQQEYTEMKA-LLDASETTSTRKIKEEEKRVNSKFDT 276
            .:..|.|:|.|.:...:         |:.::|..||.: |.|..|..     :::|....|:.:.
Yeast   247 SHNRSIAVDAVDDEDDE---------EEDEEEEEEMDSDLKDFIEDD-----EDDEDEDGSRRNL 297

Human   277 IYQILLKKKSEIQTLKEEIEQ 297
            :.. .||.:..|.|..||.||
Yeast   298 VLS-ALKNRHVIITDDEEEEQ 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM25	NP_005073.2	RING	13..53	CDD:302633	19/41 (46%)
		Interaction with influenza A virus NS1	180..450		26/126 (21%)
		HR1	180..252	CDD:294066	13/79 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..403
		SPRY_PRY_TRIM25	459..627	CDD:293971
PSH1	NP_014587.1	RING-HC_ScPSH1_like	29..72	CDD:319482	20/43 (47%)
PSH1	NP_014587.1	DNA_RNApol_7kD	149..>175	CDD:412622	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I3339
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2677
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030